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Tag: "fails" at biology news

Finding Cures For Tropical Diseases: Is Open Source An Answer?

...d produce profits for shareholders. The model thus fails in thedeveloping world, where few patients can afford to pay patented pricesfor drugs. The solution to this devastating problem, say StephenMaurer, Arti Rai, and Andrej Sali in the premier open-access medicaljournal PLoS Medicine, is to adopt an "ope...

NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis

...redundancy of the immune system--when one response fails to fight infection, others step in." The study was also conducted at NYU, by a post-doctoral fellow, Mark Trottier, Jr., PhD, now at Michigan State, and Beth Palian, currently a doctoral student at the University of Southern California. Recently, t...

NYU study reveals how brain's immune system fights viral encephalitis

...redundancy of the immune system--when one response fails to fight infection, others step in." The study was also conducted at NYU, by a post-doctoral fellow, Mark Trottier, Jr., PhD, now at Michigan State, and Beth Palian, currently a doctoral student at the University of Southern California. Recently, t...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...the red cells of patients with sickle cell disease fails to process nitric oxide properly. As a result, they reported, the membranes of sickle red blood cells are deficient for the form of nitric oxide normally released by the cells. The blood cells therefore fail to open blood vessels normally. Red cells...

Leprosy microbes lead scientists to immune discovery

...ve immunity against bugs that invade our cells--or fails to. Now we know the players, and we would love to look at them in other diseases such as tuberculosis in the lungs and juvenile diabetes." Harvard School of Public Health is dedicated to advancing the public's health through learning, discovery, and...

Gladstone investigators discover how resting T cells avoid HIV infection

...y the small form in resting CD4 T cells, where HIV fails to grow, and only the large form in activated CD4 T cells, where the virus efficiently grows and wreaks havoc. They further showed that blocking production of the small, active form of A3G in resting CD4 T cells was sufficient to make these normally ...

Ancient immune defense mechanism is no match for HIV-1

...ontains alternative transcriptional activators, it fails to spread productively in human cells." The researchers also suggest that their findings raise a challenge to proposed therapeutic strategies making use of RNAi. "Because HIV-1 evades all other RNAi by point mutations, we reason that its requirement ...

Hopkins AIDS experts issue warning about global efforts to provide drug therapies

...ven a plan with no public input can backfire if it fails to win local support," says McGough, a research fellow at Hopkins' Institute of the History of Medicine. "It is as important to make sure that the decision-making body is politically legitimate and accountable to the public as it is to agree on the c...

Random gene expression may drive HIV into hiding

...idered one of the biggest reasons why drug therapy fails to eradicate HIV from patients. The new findings, which will be published in the July 29, 2005, issue of the journal Cell, could help scientists design new and more effective treatments to slow or halt the progression of HIV infection. HIV normally ...

New vaccine protects more effectively against tuberculosis

...erculosis, termed BCG is available which, however, fails to protect against the most frequent form of disease, pulmonary tuberculosis in adults. A more efficient vaccine is urgently needed for control of this global threat. Recombinant BCG, which express listeriolysin and is deleted for the urease gene, ...

Insulin pulses keep the liver lean

... synthesis in the liver. This protective mechanism fails in obese mice and mice with persistently high levels of insulin, the researchers also found. The findings suggest that periods of fasting between meals play a critical role in maintaining a lean and healthy liver by allowing insulin levels to rise a...

Several minute intermediate stage in virus-cell fusion discovered; opportunity for drug development

...the rare cases in which the pore does not open, it fails to infect the cell at all. "It's like a space craft docking on a space station," said Young. "If you try to open the inner door before the pressures have equalized, you can tease it open a little bit but it keeps closing on you until there's enough ...

Promising therapies for haemophilia & heart disease

...isease, primarily affecting males, where the blood fails to clot causing potentially life-threatening 'bleeds'. About one in 6000 Australian males is born with haemophilia in severe, moderate or mild form. People with haemophilia rely on intravenous infusion of recombinant Factor VIII clotting protein. Pr...

Micro RNAs play role in egg making

... miRNAs are missing from a developing egg, then it fails to develop to term, and the net result is infertility," said lead author Richard W. Carthew, Owen L. Coon Professor of Molecular Biology at Northwestern. "It is intriguing to think that miRNA dysfunction might be at the root cause of certain forms of...

OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis

...offer important clues about why the nervous system fails to repair itself and suggest ways that at least some forms of brain damage could be reversed. The research is published in the August edition of the scientific journal Nature Medicine. "For many years, scientists have understood that damage to the i...

Molecular Partners Required For Appropriate Neuronal Gene Repression

...offer important clues about why the nervous system fails to repair itself and suggest ways that at least some forms of brain damage could be reversed. The research is published in the August edition of the scientific journal Nature Medicine. "For many years, scientists have understood that damage to the i...

Anti-cancer drugs may hold promise for premature aging disorder

...ated protein that is called progerin. This protein fails to integrate properly into the lamina, thereby disrupting the nuclear scaffolding and causing gross disfigurement of the nucleus. Cells with progerin have a nucleus with a characteristic "blebbed," or lobular, shape. To find its way to the lamina, ...

Plants have a double line of defence

...nside the cell. Only if this second mechanism also fails can the originally non-virulent grass powdery mildew fungus colonise the plant. The Max Planck research has now demonstrated that the nonhost resistance of plants develops out of a defence system with at least two steps. These steps determine whethe...

Penicillin, amoxicillin: Step aside for strep throat treatment

...ere cases. But most doctors would view a drug that fails in one out of four patients, as penicillin does in strep cases, as unacceptable, Pichichero said. To understand why the older drugs don't work as well, consider a child's throat as a battleground for many types of bacteria vying for dominance. Repea...

Discovering the first steps in transcription-coupled repair

...- can also cause clinical CS. When transcription fails Genes are copied into messenger RNA by the large...ive methods available in a pinch. Only if all else fails would the RNAPII be destroyed, forcing transcription to start fresh." In this first in a series of ...

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