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Tag: "fail" at biology news

Common viruses may cause cancer

...MV), but that the resulting hybrid cells do indeed fail to proliferate. However, the researchers discovered that if one of the fusion partners carried a particular "predisposing" gene mutation (in the oncogenes E1A or Myc, or in the tumor suppressor gene p53), then a significant proportion of the resultin...

HIV-infected adults in Botswana respond positively to ARV therapy public treatment program

...e Study to examine the three main reasons patients fail ARV therapy: drug resistance, tolerability and adherence. This study is also called the "Tshepo" Study, "Tshepo" is the word for "hope" in Setswana. This study was recently extended through 2007, making it the largest and longest running adult ARV tr...

New Therapeutic Target Identified In Inherited Brain Tumor Disorder

...e Study to examine the three main reasons patients fail ARV therapy: drug resistance, tolerability and adherence. This study is also called the "Tshepo" Study, "Tshepo" is the word for "hope" in Setswana. This study was recently extended through 2007, making it the largest and longest running adult ARV tr...

Largest computational biology simulation mimics life’s most essential nanomachine

...e Study to examine the three main reasons patients fail ARV therapy: drug resistance, tolerability and adherence. This study is also called the "Tshepo" Study, "Tshepo" is the word for "hope" in Setswana. This study was recently extended through 2007, making it the largest and longest running adult ARV tr...

Texas scientists discover how a hepatitis C protein promotes liver cancer

... often causes debilitating side effects. Those who fail treatment are at risk for fatal cirrhosis or developing liver cancer. Researchers have known for a long time that hepatitis C virus infection can lead to liver cancer. But how the virus goes about this has been unclear. The UTMB group discovered t...

Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer

...reatments such as chemotherapy or hormonal therapy fail to cause tumor regression, the cause is often a malfunction of a natural pathway called apoptosis, which breaks down cells in the body. Many breast cancer cells require estrogen for survival (called estrogen receptor–positive breast cancers), and ap...

Feinstein researchers identify intelligence gene

...y ultimately interfere with cell communication and fail to protect brain cells from dying, with a resulting negative impact on cognition and intelligence. ...

'Uniquely human' component of language found in gregarious birds

... study. "There are many ways for an experiment to fail and most failures are not scientifically interesting. I immediately thought: we could do that in starlings." Nusbaum, Margoliash and psychologist Kimberly Fenn had previously collaborated on studies of the role of sleep in speech perceptual learni...

Marine mammals are on the frontline of failing ocean health

...llows you to go where mere field observation would fail you," says Krahn. "We're filling in the pieces of a puzzle." Some suspect that declines of killer whales in Puget Sound may be linked directly to contaminated fish or increased susceptibility to stresses like vessel traffic. Similarly, adverse hea...

UCSD biologists find new evidence for one-way evolution

... reconstruct the evolution of complex traits often fail to support it. This is because it is often difficult to reconstruct characteristics of extinct ancestors with any certainty. The study contradicts earlier studies of complex trait evolution, which have tended to favor multiple reappearances of comp...

St. Jude projects 90 percent cure rate for ALL

...trongly suggest the likelihood that treatment will fail the child, the authors reported. For example, a chromosomal abnormality called the TEL-AML1 fusion gene, which is an abnormal combination of two separate genes, confers a relatively favorable outlook for patients with this form of ALL. But patients w...

Computer simulation hints at new HIV drug target

...fective copies of itself. When protease inhibitors fail -- as they often do with a fast-mutating virus like HIV -- new drug targets become vital. "Recognizing these variations in conformation -- the three-dimensional arrangement of the amino acids that make up a protein -- is the first step in identifyin...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...fective copies of itself. When protease inhibitors fail -- as they often do with a fast-mutating virus like HIV -- new drug targets become vital. "Recognizing these variations in conformation -- the three-dimensional arrangement of the amino acids that make up a protein -- is the first step in identifyin...

Evolution follows few of the possible paths to antibiotic resistance

...ational paths of the enzymatic variant we examined fail to continuously increase resistance. Importantly, this is not a reflection of the fact that many more mutations reduce biological function than improve it, because in the present case each mutational path is composed exclusively of mutations known jo...

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

...tic success, and many development-stage antibodies fail in clinical trials due to lack of demonstrated efficacy. Scientists at Xencor, a biotherapeutics company developing protein and antibody therapeutics, said the changes it made to the antibody Fc regions increased antibody effector functions such as...

Queensland scientists identify molecule that links both sides of the brain

...llions of individual nerve fibres. If these fibres fail to reach their correct targets in the opposite hemisphere, people can suffer from epilepsy, and experience some degree of mental retardation. "Our study is the first to identify a growth molecule that guides young nerves away from the corpus callos...

Successful transplantation from pig embryos to mice

...ily injections to replace the insulin their bodies fail to produce, as well as a host of risks that includes blindness, amputation, kidney failure, and heart disease. For many, particularly those afflicted with juvenile diabetes, transplants of the pancreatic tissue in which insulin is produced might alle...

Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein

...viously reported that mice lacking the K17 protein fail to grow a healthy coat of body hair during the first week after birth. It turns out that without K17, cells in the hair follicle die too soon, which results in a thin coat of fragile hair, a condition resembling alopecia or thinning, balding hair. Th...

Mice learn tasks that may help treat human psychiatric disorders

...rs on the next cards I turn over. "But you might fail to tell me the numbers because you are continuing to pay attention to the previous set - the card suits. You've both learned to pay attention to the suits and that the numbers are irrelevant so you should ignore them." Mice compose the majority of ...

Gene linked to rare disease activates fat breakdown

...ants with the mutations found in patients with CDS fail to activate ATGL, they found. Moreover, the joint expression of CGI-58 and ATGL limits lipid accumulation in cultured cells, while treatments that block CGI-58 in fat cells inhibit the removal of stored triglycerides. Finally, the addition of normal ...

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