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Tag: "fail" at biology news

Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses

...arious flaviviruses. But the treatment appears to fail in about half of cases. Dengue virus, West Nile virus and yellow fever virus have a protein called NS4B that prevents interferon from functioning properly. It was thought that the tick-borne flaviviruses would use the same protein, so the NS5 finding...

Sugar helps control cell division

...y its genetic material and make new nuclei, but to fail to divide in two. The end result is cells with more than one nucleus -- a situation fairly common in cancer cells. "Cells with more than one nucleus can survive, but they are dysregulated -- things just don't go right," says Slawson. "The longer the...

Scientists find a maturity gene in fly

...s they enter adulthood, sometimes when their heads fail to emerge from their bodies. "We identified a gene that is needed for the animal to progress through normal juvenile development to maturation," says University of Utah geneticist Carl Thummel, the study's principal author. "Without this gene, the j...

MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools

...s they enter adulthood, sometimes when their heads fail to emerge from their bodies. "We identified a gene that is needed for the animal to progress through normal juvenile development to maturation," says University of Utah geneticist Carl Thummel, the study's principal author. "Without this gene, the j...

Quick identification needed to save Florida's citrus industry from devastating disease

...reads throughout the tree with lopsided fruit that fail to color properly. Citrus greening has seriously affected citrus production in Asia, Africa, the Indian subcontinent and the Arabian Peninsula, and was recently discovered in Brazil. ...

Most embryos produced during IVF do not result in live births

... embryos transferred during in vitro fertilization fail to become live births, highlighting the need for improving diagnostic techniques to identify viable embryos. Published in the August issue of Fertility and Sterility, the study reviewed seven years of U.S. statistics from all the fertility clinics t...

Tiny roundworm's telomeres help scientists to tease apart different types of aging

...licate. The cell's structure and function begin to fail as it enters this state of growth arrest, called replicative senescence. "But even in very old people, blood cells, which divide continuously, don't have critically short telomeres. In humans and, as we know now, in worms, telomere length is certain...

OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis

...acity to repair the brain and spinal cord but they fail to do so. Our studies have revealed that there is a particular signal in the damaged brain that prevents these cells from restoring lost myelin. We're hopeful that we can develop methods to counteract this process in animal models in our search for h...

Molecular Partners Required For Appropriate Neuronal Gene Repression

...acity to repair the brain and spinal cord but they fail to do so. Our studies have revealed that there is a particular signal in the damaged brain that prevents these cells from restoring lost myelin. We're hopeful that we can develop methods to counteract this process in animal models in our search for h...

Hepatitis C complicated by morphine withdrawal

... the question of why so many HCV-infected patients fail to respond to IFN-alpha treatment. Although the clinical relevance of this study remains to be determined, these data showing that withdrawal promotes HCV expression by suppressing anti-HCV factor (IFN-alpha) production by liver cells suggests tha...

Research casts doubt on circulating stem cells

...tary disease. Due to a genetic defect, the muscles fail to produce properly functioning dystrophin, an important muscle protein. Those affected develop progressive muscle wasting. They only have a life expectancy of 15 to 20 years. "In mice with DMD we have replaced the bone marrow with healthy marrow ma...

Scientists unpick genetics of first 15 minutes of life

...n the maternal (mother's) genome explains why eggs fail to produce a zygote - or early embryo - despite the presence of 'healthy' sperm. Although the researchers use the fruit fly Drosophila melanogaster to discover the basic genetic processes of sex, the same genetic processes are present in all sexuall...

Researchers use brain scans to predict behavior

...can predict whether the volunteers will succeed or fail at the game. "Before we present the task, we can use brain activity to predict with about 70 percent accuracy whether the subject will give a correct or an incorrect response," says lead author Ayelet Sapir, Ph.D., a postdoctoral research associate...

Many smokers fail to quit after cancer diagnosis

...cer management and that healthcare providers often fail to advise smokers to quit. The health risks of smoking are well understood. Smoking is linked to many primary diseases, such as cancer and respiratory diseases. In patients diagnosed with cancer, smoking is also associated with poor treatment outc...

Gene controls whether fear is a factor

...ack the gene, show a decreased memory for fear and fail to recognize danger in innately aversive environments." By contrast, he added, the mice depleted of stathmin perform normally in a test of spatial learning. Fear reactions represent a spectrum of behaviors that vary from those that are inborn to th...

Penicillin, amoxicillin: Step aside for strep throat treatment

...re more effective against strep. Nearly all drugs fail some of the time, Pichichero said, and doctors accept some risk of failure as a trade-off for other factors like convenience, cost to families, and likelihood that a less powerful medication can kill the bug just as well as a more powerful drug. In t...

Discovering the first steps in transcription-coupled repair

...ation -- victims have an unusually small brain and fail to grow and develop normally after birth; pronounced wasting usually begins in the first year of life. As they grow older, CS sufferers look increasingly aged, with faces marked by sunken eyes. Average life expectancy is only 12 years and few survive...

Harnessing genomic research

...ion between the brain and the body are injured and fail to regrow. The loss of this communication leads to paralysis and loss of sensation. Scientists at King's College London and Oxford BioMedica are investigating a receptor which allows nerve cells to reform severed connections. Identifying the genes th...

Switching to new anti-bacterial targets: Riboswitches

...mpound related to the vitamin. Bacteria and fungi fail to grow in pyrithiamine and become resistant by acquiring mutations in their riboswitches. This work, in combination with the recently solved crystal structures of purine riboswitches, opens a path to the directed design of drugs targeting riboswitch...

Feds give researchers ok for safety test of adult stem cells in patients with heart disease

...ill replace or supplement those blood vessels that fail to adequately supply oxygenated blood to heart tissue. The method was developed by Mary Laughlin, M.D., a hematologist, and Vincent Pompili, M.D., a cardiologist, both of Case, UHC and the National Center for Regenerative Medicine which has the missi...

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