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Tag: "fail" at biology news

Bioartificial kidney under study at MCG

...examples, kidneys can become ischemic and begin to fail if blood pressure drops because of a long surgery with significant blood loss. Infection can further reduce blood flow to the kidneys. Ironically, some antibiotics patients need for these infections also can harm the kidneys. Even the contrast medium...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

... occur. Without it, cells do not stop dividing and fail to differentiate into the normal structures of the worm ?instead they make an excess of their cells. After identifying let-7 as a cell division regulator, Slack's team used bioinformatics and found the relationship to Ras. Let-7 in humans is identic...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...er an alternative treatment for those children who fail to respond to enzyme replacement therapy, he said. Even for those that respond well to enzyme infusions, treatment requires weekly injection of a large amount of the enzyme. "Gene therapy has the potential to reverse the course of the disease with a...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

...lliliter, the transplantation was likely either to fail or be significantly slow in reconstructing the T cell population. "This is the first demonstration that high levels of sjTREC in a potential stem cell recipient can predict that their thymus will successfully reconstitute their T cell population usi...

Tiny scaffolding allows stem cells to become working fat cells

...ium. While useful, these "two-dimensional" patches fail to mimic all the tasks performed by cells in vivo. Specific genes, proteins and hormones normally produced by healthy cells are often absent in two-dimensional colonies. "The PET fibers are spun out onto a mat that resembles the intracellular matrix...

Falling ants glide back to trunk to avoid dangers of forest floor

...degree turns in midair, however, so even when they fail the first time, they can execute a mid-air hairpin turn and glide in for another try. "It's an amazing discovery," said Robert Dudley, a UC Berkeley expert on flying and gliding creatures ranging from hummingbirds and lizards to moths and bees. "App...

Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals

...s. Some methods cannot be used in living subjects, fail to image cells deep inside the body or don't provide high-resolution images. Other approaches using MRI are not practical for a wide range of applications. Ahrens and his colleagues constructed a gene carrier, or vector, that contained a gene for th...

US life expectancy about to decline, researchers say

...ends, but the authors conclude that such estimates fail to consider the obesity epidemic. Olshansky and colleagues argue that current extrapolation models used to predict life expectancy do not take into consideration the health status of people currently alive. Longevity predictions are crucial for hea...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...tic possibilities, Stamler said. Current therapies fail to treat the disease itself and are instead geared...y released by the cells. The blood cells therefore fail to open blood vessels normally. Red cells taken from patients with mild sickle cell disease dilate ...

UNC launches study of liver injury caused by drugs

...ationwide and the most common reason why new drugs fail to obtain approval by the U.S. Food and Drug Administration, said Dr. Paul Watkins, DILIN Steering Committee chairman and the study's principal investigator at UNC. "This is the case even though drugs that cause liver injury are usually entirely saf...

Undesirable expatriates: Preventing the spread of invasive animals

...ment, many animals find conditions unfavorable and fail to establish. In an effort to gain insight into how frequently introduced animals become invasive, Drs. Jeschke and Strayer analyzed bird, mammal and freshwater fish introductions between Europe and North America. Jeschke comments, "We focused our st...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

...iatric acute lymphoblastic leukemia (ALL) patients fail to respond to treatment even when existing clinical predictive criteria point towards a positive treatment outcome. The research, published in the April issue of Cancer Cell, is likely to facilitate development of new strategies to combat drug resist...

UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints

... populations, our results explain how such devices fail and suggest that improvements should be made in artificial joint design," said the study's senior author K.L. Paul Sung, Ph.D., UCSD professor of orthopedic surgery and adjunct professor of cellular bioengineering. The team measured how titanium par...

Master gene controls healing of skin in fruit flies and mammals

...unds in mutant flies that lack the grainyhead gene fail to heal. "The genes involved in cuticle repair are activated very quickly, within 30 minutes after injury," said Joseph Pearson, a graduate student working under McGinnis and a coauthor of the paper. "They are activated over many cell diameters, mos...

Young Blood Revives Aging Muscles, Stanford Researchers Find

...muscles have the capacity to repair themselves but fail to do so. Rando and his group studied specialized cells called satellite cells, the muscle stem cells, that dot muscle tissue. These normally lie dormant but come to the rescue in response to damaged muscle-at least they do in young mice and humans. ...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

... human cancers, checks and balances on cell growth fail to operate, and body cells start to accumulate mutations, which ultimately may lead to cancer. Not surprisingly, the regulation of this vital safeguard has been studied in great detail for many years but mainly in tissue culture, or in vitro, models....

How exactly does the brain control breathing?

... well over 100 years is what maintains this almost fail safe vital rhythm throughout life? Experimental Physiology editor Julian Paton invited two world renowned scientists Dr. Guyenet from the University of Charlottesville and Dr. Richerson from Yale University, to use the journal as a forum to discuss ...

Drug Offers Alternative to Surgical Treatment After Miscarriage

...y prefer not to wait. Occasionally, the uterus may fail to expel the remaining fetal tissue, and in some of these cases, the uterus may become infected. Within the last few years, physicians have used misoprostol to treat pregnancy failure, and some researchers have conducted a few small studies of the d...

Sleeping Sickness Epidemic Spreading in Uganda

...y prefer not to wait. Occasionally, the uterus may fail to expel the remaining fetal tissue, and in some of these cases, the uterus may become infected. Within the last few years, physicians have used misoprostol to treat pregnancy failure, and some researchers have conducted a few small studies of the d...

Elevated temperature enhances success of viral cancer therapy

...esearchers demonstrated that resistant tumor cells fail to complete an RNA export function that is necessary for ONYX-015 replication. Interestingly, when a cellular heat shock response was induced in the resistant tumor cells, either pharmacologically or by incubating the cells at an elevated temperature...

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