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Tag: "factor" at biology news

Plankton can run, but can't hide from basking sharks

...e species are lacking, and diving behaviour is one factor contributing to surveying bias," the authors say. Unless adjusted to account for these differences in diving patterns, current surveys could be over- or underestimating basking shark abundance by at least 10-fold. Up to 10 metres long and weighing u...

Redesigned protein accelerates blood clotting

... In most cases, hemophilia is caused by a lack of factor VIII, one of several proteins that enable blood to...ntive treatment consists of genetically engineered factor VIII administered by injection, but one quarter of those born with no factor VIII suffer severe immu...

Missing Receptor Molecule Causes Tumor Growth

...n why the receptor molecule, which is an important factor in regulating cell growth, is missing. In healthy tissue, cells grow and divide - this is also true of cancerous tumors. The difference between the two lies in the regulation, which functions well in healthy tissue, but not in tumors. An important m...

Nanoparticles carry cancer-killing drugs into tumor cells

...n why the receptor molecule, which is an important factor in regulating cell growth, is missing. In healthy tissue, cells grow and divide - this is also true of cancerous tumors. The difference between the two lies in the regulation, which functions well in healthy tissue, but not in tumors. An important m...

Gene therapy advance treats hemophilia in mouse models

...eered to have Hemophilia A, which is also known as factor VIII deficiency. The findings appear in the Sept. ...enetic mutation that leaves them with little to no factor VIII protein to prevent uncontrolled bleeding. Individuals with the severe form of the disease have ...

Physical and functional interaction of key cell growth molecules linked to cancer

...ificantly advance knowledge about epidermal growth factor receptor (EGFR). EGFR is a well-studied cell surf...that stimulates cell growth by transmitting growth factor signals acting outside the cell. EGFR is often present at abnormally elevated levels in human cancer...

Treatments have same target, different responses for lung cancer patients with genetic mutation

...SCLC) have mutant versions of the epidermal growth factor receptor (EGFR). This protein activates signaling pathways involved with cell growth and survival. Previous studies have shown that small-molecule EGFR inhibitors such as gefitinib and erlotinib (Tarceva) work by blocking signals in the intracellular...

Primate virus jumps species barrier to humans for first time in Asia

...hmeat hunting and consumption may be a significant factor in viral transmission in Africa, Jones-Engel says, people in Asia have many other contexts in which they come into contact with primates, including animal markets, primate pet ownership, urban performing primates, and zoos. In addition, monkeys are s...

Microbe has huge role in ocean life, carbon cycle

...reamlining, researchers say, appears to be a major factor in the evolutionary success of SAR11, which they believe may have been thriving for a billion years or more. One scientific hypothesis holds that natural selection acts to reduce genome size because of the metabolic burden of replicating "junk" DNA w...

Simple sea sponge helps scientists understand tissue rejection

...rching the role of the molecule called aggregation factor proteoglycan, which he has recently identified as another potential player in sponge tissue rejection reactions, and which is very easy to study in sponges. The human version of this molecule, which is different from the sponge version but similar in...

Naturally occurring asbestos linked to lung cancer

...y in shipyards, has long been recognized as a risk factor for mesothelioma, a rare form of cancer affecting the lining of the lung. But in the new study, researchers found a consistent and dose-dependent association between mesothelioma and residential proximity to ultramafic rock, the predominant source of...

Newfound roadblock to interferon effectiveness against malignant melanoma

...earchers have uncovered a significant contributing factor to interferon resistance of malignant melanoma cells. The finding represents a step forward in understanding the molecular events that govern the growth of this type of cancer and the changes in gene expression and cellular signaling that underlie re...

Once given 'no respect,' cells' tiny RNAS take driver's seat

...in human cancers, but the Myc protein is the first factor identified that controls the production of microRNAs. Myc (pronounced "mick") is already known to regulate about 10 percent to 15 percent of the genes in the human genome, controlling the extent to which they are used to make proteins. Myc also is f...

Muscle repair: Making a good system better, faster; implications for aging, disease

...gen system interacts with the inflammatory, growth factor and other systems in a complicated manner, indicat...ses in proteins such as the myogenic transcription factor MyoD. "In other words, we observed accelerated repair over and above what is already a naturally eff...

Change in gene may be underlying molecular defect in some colorectal cancers

... MGMT protein function is a plausible predisposing factor for cancer through the increased occurrence of mutations? our data indicate that MGMT promoter methylation may qualify as a marker of the field defect in colorectal cancer," the authors write. In addition, "given the high lifetime risk of colorectal ...

Two designer drugs hit same lung cancer target, but only one is effective

...ing a normal but overactive EGFR (epidermal growth factor receptor) molecule, only gefitinib (Iressa) killed lung cancer cells containing a mutated EGFR molecule. The monoclonal antibody drug cetuximab (Erbitux) had little effect on the mutant signal, evidently because it strikes at a different part of the ...

Weight control protein may yield antiobesity drugs

...re a hallmark of leptin resistance, a primary risk factor for obesity, he added. Further examination found that the animals lacking SH2-B ate nearly twice as much as normal. Surprisingly, Rui said, the animals burned more calories; however, the animals still have a net positive energy imbalance of more tha...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

...ast growth factor), TGF-alpha (transforming growth factor alpha) and antiapoptotic Bc1-2," the paper added. Beneficial paracrine actions are elicited early and late after onset of ARF The study said it "provides the first clear evidence that therapy with MSC affords significant renoprotection in rats with...

Genomatix, AAAS ink agreement

...uction pathways, metabolic pathways, transcription factor knowledge, promoter sequence analysis, different Gene Ontology and MESH filters -- all in one dynamically overlayable package -- makes BiblioSpherePE even more powerful and essential for molecular biology research." ...

Suppressing growth hormone in early adulthood may prevent cancer

...pression of growth hormone and insulin-like growth factor (IGF-1) also may decrease cancer risk in those ind...n rats. He said IGF-1 is an important blood-borne factor that increases cell growth and prevents cell death and has been proposed to be a factor in the initi...

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