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Tag: "factor" at biology news

Discovery Promises Simpler Therapy for Sickle Cell Disease

...els through the release of nitric oxide is a major factor behind the disease's primary symptoms -- including oxygen deprivation and blocked vessels that can lead to pain, clots and stroke. Thus, therapies that restore nitric oxide to blood cells might serve as a useful method for treating the disease, said ...

Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

... for the body." Atherosclerosis is a contributing factor to a number of cardiovascular diseases ?the No. 1 cause of death among people in the United States. It is also highly associated with other risk factors such as smoking, obesity and diets high in fat and cholesterol. ...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

...hape of a prion amyloid fibril was the determining factor in whether one species of yeast could infect anoth...ian prion protein, so they hope to test the fibril factor in a full-length protein soon. Jones and Surewicz also note that the new findings offer "the unsett...

Stopping smallpox in its tracks: A new anti-viral approach

...bitor of signaling mediated by the smallpox growth factor (SPGF). SPGF targets the erbB-1 signaling molecule, which normally initiates an intracellular cascade that facilitates viral replication. This study shows that drugs that interfere with erbB-1 signaling inhibit SPGF-induced viral replication and sp...

Gene therapy promising for growing tooth-supporting bone

... research team has found that introducing a growth factor protein into a mouth wound using gene therapy helped generate bone around dental implants, according to a new paper in the February issue of the journal Molecular Therapy. In a patient with a sizeable mouth wound, replacing a tooth takes more than s...

New insight into regulation of blood stem cells

...SCs. "It is remarkable that a single transcription factor controls the diverse processes of self-renewal, proliferation, and differentiation" says Dr. Cooke. "The next challenge is to understand how c-Myb controls HSC numbers and use this information to develop compounds that can regulate stem cell prolifer...

Alzheimer's cognitive decline slowed

...he dying cholinergic cells near the site of growth factor gene delivery. Cholinergic neuron loss is a cardin...ue was modified in the lab to express nerve growth factor (NGF), a naturally occurring protein that prevents cell death and stimulates cell function. In surge...

Shift of weather patterns necessitates rethinking of reforestation methods

... at the site already stressed. "And this is a big factor in their survival," Taylor said. Another big factor is the subjection of new to hot dry conditions before they've had a chance to acclimate and recover ...

Duke engineers develop new 3-D cardiac imaging probe

...aintaining the size of normal TE probes was a main factor in the design since 3-D imaging inherently requires significantly more sensors than 2-D imaging," said Pua. "The original casing held enough cabling for 64 transducer elements whereas our design successfully incorporates 8 times that number." The pr...

Africa to take it on chin again with climate change

...th an increase in greenhouse gases appears to be a factor in these expected 21st-century changes to Africa's...he impact of greenhouse gas increases, is the main factor behind the Sahel's recent swing from drought to moist conditions, the researchers believe. "Changes...

Scientists discover that three overlapping signals in embryo help get the backbone right

... that in later stages of development, this protein factor is critical in laying down cartilage to make joints, and even plays an important role after birth. Recently, he and Stanford University colleagues showed that noggin may be important in preventing the premature fusion of the bones in the skull, and t...

Protein Discovery Could Unlock The Secret To Better TB Treatment

...ture of a protein known as resuscitation promoting factor (Rpf). Five versions of the Rpf protein exist in TB bacteria. The paper's unveiling of the molecular structure of Rpf could be crucial to the treatment of TB in the future. Dr John Ward, Dept of Biochemistry and Molecular Biology at UCL, said: "The ...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

...er cells have a mutation in their epidermal growth factor receptor (EGFR), but that does not predict response to the targeted therapy in other forms of cancer, Ueno says. "We find here that as long as CDK2 is suppressed, the drug works, so developing an accurate test for CDK2 activity would be a boon for d...

Confocal imaging promises early detection of skin cancer

...user-friendly design. “We can cut these costs by a factor of ten, resulting in a 20,000-euro machine that is affordable for many outpatient centres.?/p> Trials at two university hospitals ?in Regensburg, Germany, with experienced dermatologists, and in Brescia, Italy, with people who were not experts in...

Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer

...to bind to and inhibit vascular endothelial growth factor (VEGF). VEGF is a protein that plays a critical role in tumor angiogenesis. “It is noteworthy that a previous company-sponsored trial in patients who received prior chemotherapy for advanced disease did not show a benefit with bevacizumab in combina...

Signs of aging: Scientists evaluate genes associated with longevity

...-2 gene, which is a principal lifespan-determining factor in C. elegans. Worms that lack fully functional daf-2 exhibit significantly extended lives, persisting approximately twice as long as their wild-type counterparts. Daf-2 was first reported as a critical aging-associated gene in 1993, but since that ...

Measles Deaths Worldwide Drop By Nearly 40% Over Five Years

...rt of the Measles Initiative has been an important factor in the marked reduction of measles deaths in Africa. Launched in 2001, this successful partnership's core founding members are WHO, UNICEF, the American Red Cross, the United Nations Foundation and the Centres for Disease Control and Prevention of th...

Gladstone investigators discover how resting T cells avoid HIV infection

...e not. The team discovered that a potent antiviral factor called APOBEC3G (A3G) is the key. The team, worki...ing T-cells due to a simple lack of some essential factor or nutrient," says Greene, a professor of medicine, microbiology and immunology at the University of...

Science study holds implications for gene therapy and stem cell biology

...nt gene-based therapies, but also a potential risk factor for leukemia later in life. "We still need to learn how many risks we can tolerate in gene therapy, just as in other forms of experimental medicine," Dr. Baum said. In 2003, Dr. Baum established a research team in the molecular and gene therapy prog...

Mouse with designer liver has enhanced glucose tolerance, insulin response

...tion. Insulin resistance in the liver is a crucial factor in the development of hyperglycemia and hypertriglyceridemia in individuals who suffer type 2-diabetes. Precisely how insulin-initiated signals are modulated in liver cells for glucose uptake and metabolism is unknown. Gen-Sheng Feng, Ph.D., a Profe...

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