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Tag: "factor" at biology news

UCSD researchers maintain stem cells without contaminated animal feeder layers

...kes advantage of a previously unidentified soluble factor this is secreted from mouse feeder layers to maint... form and structure. The team then eliminated each factor and pluripotency was assessed. At first, the results were narrowed to three molecules, with activin ...

Study shows nanoshells ideal as chemical nanosensors

...hells' enhance sensitivity to chemicaldetection by factor of 10 billionNew research published in the Proceedings of the National Academy ofScience finds that tailored nanoparticles known as nanoshells canenhance chemical sensing by as much as 10 billion times. That makesthem about 10,000 times more effectiv...

Highly adaptable genome in gut bacterium key to intestinal health

...unities among different people may be an important factor that influences predisposition to obesity and obesity-related disorders such as diabetes and heart disease The bacterium of the study, called Bacteriodes thetaiotaomicron or B. theta, is among the most abundant species in the human gut microbial com...

Studies reveal methods viruses use to sidestep immune system

...nals to other proteins to activate a transcription factor called interferon regulatory factor 3 (IRF-3). This protein turns on the genes responsible for producing interferon, which neutralizes v...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

...e and another compound, IGF-1 (insulin-like growth factor 1) on adult rats and found paradoxical effects, according to William E. Sonntag, Ph.D., professor of physiology and pharmacology at Wake Forest University Baptist Medical Center and the lead investigator. "Things that happen when you are an adolesce...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

...s. Thispathway, which is linked to critical growth factor receptors and isinvolved in programmed cell death, is aberrant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and other...

Genetic Variation Visualization - From EMBL

...s. Thispathway, which is linked to critical growth factor receptors and isinvolved in programmed cell death, is aberrant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and other...

New Mixing Method for Microchip-Sized Labs

...s. Thispathway, which is linked to critical growth factor receptors and isinvolved in programmed cell death, is aberrant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and other...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

... had earlier published research on a transcription factor called Foxl1 that is also expressed in the colon, but in a different layer of cells, adjacent to the epithelium, called the mesenchyme. They had seen that mice that are deficient for the Foxl1 protein show a similar accumulation of the beta-catenin p...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...to be regulated by alcohol involved a nerve growth factor called Bdnf. Bdnf is found in the brain and is a vital part of nervous system development. "We found that the interaction between the Bdnf gene and several other genes that interact with Bdnf were all regulated in one region of the brain that is kno...

How an AIDS-Related Cancer Unleashes Inflammation

...r HIV have strikingly reduced the immunodeficiency factor in developed countries; so new cases of KS have gone down by 90 percent since 1996,?he said. There are also forms of KS not linked to HIV, Ganem added, and these studies could also lead to new treatments for those forms of the illness. ...

Chemists identify key gene in development of type 1 diabetes

...alth System in Manhasset, N.Y. "It is not the only factor involved in this complex disease, but it is certainly a promising target for its prevention and treatment." In preliminary studies by the research group, specially bred mice that lacked the gene for the MIF protein failed to develop diabetes compare...

International HapMap consortium expands mapping effort

...nome for hereditary factors in common disease by a factor of 20 to 40 compared with current, brute force approaches. "This new partnership underscores the private sector's enthusiasm for the HapMap and its potential as a tool for the understanding of disease. The willingness of these firms to contribute to...

Vascular structure and function improve with diet and exercise

...otid artery distensibility was the only structural factor that significantly improved. It rose about 16 percent. Petrella said that the other factors may improve as patients are followed for one year. One in three American adults has high blood pressure and two-thirds to three-fourths of people with diabet...

Towards precise classification of cancers based on robust gene functional expression profiles

...alth System in Manhasset, N.Y. "It is not the only factor involved in this complex disease, but it is certainly a promising target for its prevention and treatment." In preliminary studies by the research group, specially bred mice that lacked the gene for the MIF protein failed to develop diabetes compare...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

... and cerebral palsy; bacterial infection is a risk factor for Parkinson's disease. Up to 20 percent of pregnancies have complications involving infections of the uterus and its contents, a number that will rise as more children are born premature. In the study, a team led by Staci Bilbo, PhD, injected a gr...

A new study examines how shared pathogens affect host populations

...ce and therefore has been considered as a negative factor for humans, wildlife, and species of agricultural importance. Many pathogens like malaria, Lyme disease or West Nile encephalitis that infect multiple hosts are commonly transmitted by vectors, and their transmission rate is often thought to depend o...

How the environment could be damaging men's reproductive health

... of the genitalia. An interesting significant risk factor was the father's weight; babies born to underweight fathers (body mass index less than 20kg/m2) were six times more likely to have undescended testes. However, Dr Jorgensen said: "This finding should be treated with caution because the number of cas...

Variation in women's X chromosomes may explain differences among individuals, between sexes

...ic differences should be recognized as a potential factor to explain sex-specific traits both in complex disease, as well as normal gender differences," he continued. Notwithstanding the genomic and biological significance of these sex-specific differences, many questions remain, Willard said. For example,...

BioMed Central welcomes the new National Institutes of Health public access policy

...ample set by NIH. All NIH grantees now have a new factor to take into account when choosing where they wish to publish their research. To fulfil the NIH request, authors publishing with most of the traditional subscription publishers will be expected to go through a process of resubmitting their papers to ...

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