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Tag: "factor" at biology news

Key heart and Alzheimer's disease protein imaged for first time in native state

...tanding of the protein's functioning will be a key factor for development of future therapeutic intervention...dstone. Next to one's age, the greatest known risk factor for Alzheimer's disease is the gene for apoE4. ApoE4 is associated with 40-60 percent of cases of sp...

UCLA scientists uncover mechanism of response to targeted therapy

... is to regulate a protein called hypoxia inducible factor (HIF). When patients lost VHL, they had high levels of HIF. Thomas said the cancer cells became dependent on HIF to grow, so high levels of the protein gave the cancer cells a growth advantage. CCI-779 had previously been tested at UCLA in prostate ...

Polymer aids in blood clotting, pointing way to new treatment

...tion cascade -- the contact-activation pathway and factor V, a protein that forms thrombin -- leading to fibrin and clots. Finally, he said, polyphosphate delays the breakdown of clots, which causes renewed bleeding. "The net effect is accelerating the rate at which blood clots form and then prolonging how...

Georgia Tech accelerates drug discovery with new IBM supercomputing cluster

...duce the number of compounds they must screen by a factor of 10." The 1000-node Cluster 1350 system built on IBM BladeCenter® systems and powered by dual-core AMD Opteron TM processors is capable of performing more than 8.5 trillion calculations per second, which would place it as the world's 41st most po...

Mice lacking social memory molecule take bullying in stride

...lated in the circuit by brain derived neurotrophic factor (BDNF), which is known to play a key role in memory ( http://www.nimh.nih.gov/Press/prbdnf.cfm ). Berton, Nestler and colleagues suspected that BDNF plays a similarly pivotal role in social learning. To find out, they first subjected mice to a dif...

Sociality of sweat bees evolved simultaneously during climate change

.... "We believe that climatic change was a critical factor in the evolution of social behavior in these bees," said Bryan Danforth, associate professor of entomology at Cornell. Sweat bees are eusocial, he explained, which is a type of social behavior in which the animals have permanently sterile worker cast...

Avian flu transmission to humans may be higher than thought

...hat having poultry in the household was not a risk factor for developing a flu-like illness, but having direct contact with sick or dead poultry produced the highest risk for flu-like illness. "Low socioeconomic status, female sex, and young or old age were also risk factors for the disease," they note. Th...

Nearly half of people who need cholesterol treatment don't get it

...ad" cholesterol that is too high ?are a major risk factor for cardiovascular disease, which is the leading cause of death in the United States. "Cardiovascular disease is a significant health problem in this country and lipid-lowering therapy has been proven to help prevent it," said Goff, a professor of p...

Study: Paramedics save more lives when they don't follow the rules

...tory experiments, we found that the most important factor of survival is to keep the blood moving through the body by continuous chest compressions," said Dr. Ewy, who pioneered the CPR Research Group at the Sarver Heart Center. "Stopping chest compressions for ventilations was far more harmful than helpful...

Evolution follows few of the possible paths to antibiotic resistance

... resistance to a widely prescribed antibiotic by a factor of roughly 100,000. Their work indicates that of 120 harrowing, five-step mutational paths that theoretically could grant antibiotic resistance, only about 10 actually endow bacteria with a meaningful evolutionary advantage. The research is publishe...

Mayo Clinic researchers challenge sepsis theory

...e been focusing too exclusively on a single causal factor of sepsis for the last 150 years and, as a result, therapeutically aiming at the wrong target -- the bacteria and the poisons they produce," says senior author Jeffrey Platt, M.D. "That's why the death rate remains so high despite efforts to block th...

Uncovering sex-change secrets of black sea bass

...t temperatures. But temperature is hardly the only factor involved. Sex ratios and density also come into play. Berlinsky's team found that females were more likely to change sex when no males were present in the tank. Additionally, the fish were more likely to turn into males when kept in crowded tanks. B...

Genetically engineered mosquitoes show resistance to dengue fever virus

...remained fertile and were able to reproduce, a key factor for any future strategies that may involve replacing mosquito populations with their genetically modified counterparts. The results were published this week in the early online edition of the Proceedings of the National Academy of Sciences. "These ...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

Scientists have discovered that a stem cell factor overexpressed both in brain tumor cells and in neu...hal types of tumor, malignant gliomas. Stem cell factor (SCF) is an important growth factor for multiple cell types. Research has shown that SCF is expresse...

Efficiency, not more doctors, is the prescription for aging population

...put per 1,000 chronically-ill patients varied by a factor of five, from about 6 per 1,000 to almost 30 per 1,000. For example, patients treated at the Mayo Clinic used fewer than 9 physicians on average, among the lowest in the country. By contrast, patients treated at New York University Medical Center, ...

Molecular force field helps cancer cells defend against attack

...h the protein known as vascular endothelial growth factor receptor 3, or VEGFR-3. The protein is tied to the growth of channels in the lymph system that serve as cellular superhighways for cancer spread and is found in breast, colon and thyroid tumors. Cance and colleagues were the first to pull FAK out of...

Dying of excitement

...ed a binding site for the activating transcription factor AP-2 into a binding site for the repressor GCF2 -- a swap that inhibited promoter activity in transfected rat brain cells. Whether the mutant promoter decreases EAAT2 expression in the human brain, as would be predicted, remains to be tested. ...

New organic substrate

...plants are grown in small containers, the limiting factor is the oxygen that can reach the roots; thereby, a substrate much more porous than earth is needed. Normal soil encloses some 50% of air in its interior, while this substrate encloses 90% of air and 10% of solid material. This is why these substrates...

Newly discovered killer cell fights cancer

...mal protein produced by cancer cells, and a growth factor for NK cells. The drug-growth factor combo served as a lure, leading the IKDCs to tumors implanted in the mice. The results were that tu...

Study finds 60 new genes controlled by DNA snippet

...ecause they are "shaped" to partner with a nuclear factor called serum response factor (SRF) and several other proteins within a genetic regulatory network. Throughout a human life, such...

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