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Tag: "expression" at biology news

Viral DNA sequence a possible trigger for breast cancer

...contained in the Env protein of MMTV and show that expression of Env in mouse breast cells transforms them. This...ation of viral DNA into locations that trigger the expression of host cancer-causing genes. An intriguing wrinkle to this study is the previously reported presenc...

Man and mouse share genome structures

...ture, called chromatin, is a key regulator of gene expression in healthy and diseased cells, Bernstein said. Chromatin is composed of DNA spooled around bundles of histone proteins, and resembles a chain of beads which is then compressed into a working chromosome. Chemical tags placed on the histones alter the ...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...ns called transcription factors in controlling the expression of genes. Spiegelman and Jiandie Lin, PhD, the paper's lead author and a researcher at Dana-Farber, have previously discovered the PGC-1 co-activator family and several of its biochemical activities. The Dana-Farber researchers made the discovery in...

A new mechanism of regulating RNA degradation

At first, we thought that gene expression was modulated only by transcription factors. Then ...ts and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ways to control gene ex...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

At first, we thought that gene expression was modulated only by transcription factors. Then ...ts and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ways to control gene ex...

Spleen may be source of versatile stem cells

...viously unknownexample of normal, controlled Hox11 expression in an adult mammal."Co-authors of the SAGE KE report are first author Shohta Kodama, MD,PhD, of the MGH Immunobiology Laboratory, and Miriam Davis, PhD, ofGeorge Washington University. The group's research is supported bygrants from the Iacocca Found...

Dysentery uses 'sword and shield' to cause infection

...stroyed by the body's immune responses through the expression of a molecule that acts as a shield on its surface." The researchers found that shigella, the bacteria causing dysentery uses a Type III secretion system to inject proteins into human cells. This causes the cells to become inflamed, resulting in sym...

Another Look Finds Promising Proteomics Test is Not Biologically Plausible

...um in the second data set, but “changes in protein expression associated with cancer should affect only a few specific peaks, not the entire spectrum.?/p> Furthermore, the researchers say some of the protein peaks were found in regions of the spectra where, for technical reasons, mass spectrometry cannot be...

Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering

...rape-- Dr. Matias Kirst who studied SNP effects in expression analysis ofdiverse species using an early prototyp...roups with a single,standardized platform for gene expression research, they can easilycompare results, build reliable databases and move science forward morequic...

New species from old data

...um in the second data set, but “changes in protein expression associated with cancer should affect only a few specific peaks, not the entire spectrum.?/p> Furthermore, the researchers say some of the protein peaks were found in regions of the spectra where, for technical reasons, mass spectrometry cannot be...

Cracking the olfactory code in bees

...um in the second data set, but “changes in protein expression associated with cancer should affect only a few specific peaks, not the entire spectrum.?/p> Furthermore, the researchers say some of the protein peaks were found in regions of the spectra where, for technical reasons, mass spectrometry cannot be...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...r the same set ofhuman tumor tissues. Overall, the expression profiles of portions ofindividual samples were hig...bs. “Thisstudy is a key first step in moving gene expression data fromsmall-scale bench science into large-scale clinical evaluation,?saidJames Jacobson, Ph.D., ...

Signaling protein builds bigger, better bones in mice

...um in the second data set, but “changes in protein expression associated with cancer should affect only a few specific peaks, not the entire spectrum.?/p> Furthermore, the researchers say some of the protein peaks were found in regions of the spectra where, for technical reasons, mass spectrometry cannot be...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

...lsoverproduce Cth2. This protein binds to the gene expression machineryof more than 80 different genes and targets these molecules, calledmessenger RNA, to be destroyed or degraded. Without messenger RNA, agene cannot translate its genetic code into proteins that carry out itsintended functions.Thiele said the ...

Novel Enzyme Shows Potential As An Anti-HIV Target

...pends on adequate Tat supplies. And since HIV gene expression relies on SIRT1’s enzymatic activity, inhibiting SIRT1 could prove to be a promising anti-HIV therapy. Future study will have to verify whether inhibiting SIRT1 can successfully put the brakes on HIV transcription and control the virus (See also “A ...

Live Recombinant Adenovirus Vaccine Technique Explored

... would be expressed using the virus' own late-gene expression machinery. L1 is expressed at very high levels in some recombinants. Dr. Ketner believes that the replicating live recombinant adenovirus model shows promise as a means of developing economical and long-lasting vaccines for many illnesses. Ongoing r...

Enzyme allows B cells to resist death, leading to leukemia

...ool of Medicine nowdemonstrate that high levels of expression and altered cellularlocation of an enzyme in B cells known as Lyn, contributes to thedevelopment of B-CLL. The authorsexamined leukemia cells from 40 patients with B-CLL and compared themwith lymphocytes from normal donors. They found that Lyn was m...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...., senior author of the study. "By restricting the expression of introduced genes to muscle, the immune response...to the new enzyme, compared to those in which gene expression was not limited to muscle, they found. Moreover, intravenous administration of the muscle-targeted ...

Enzyme shown to help protect genomic stability

... Ph.D., the Hilary Koprowski Professor in the gene expression and regulation program at Wistar and senior author...e histones, the genes cannot be accessed and their expression is repressed. When the coils of DNA around the histones are loosened or the histone molecules are al...

U-M scientists find genes that control growth of common skin cancer

...ally engineered mice in which they couldmanipulate expression of an Hh pathway component, called Gli2 ,effective.... In addition, theresearchers found that sustained expression of Gli2 is necessary forthe continued growth of these tumors. When Dlugosz and colleaguesturned Gli2...

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