exposed 2 10

Tag: "exposed" at biology news

Soil-bound prions that cause CWD remain infectious

...ged the bacterium as an invader. Researchers also exposed CGD mice to the bacterium, recreating the appearance of the patient's infection. Researchers were then able to retrieve the bacteria from the mice's spleens, which are disease-fighting organs. These factors all support the pathogenic nature of the ...

Study shows that cells have a natural defense against HIV

... copy of its RNA genetic material. The researchers exposed newly infected cells to the drugs and then measured changes in the amount of cDNA over time. These experiments showed that the cDNA was destroyed faster in cells with normal XPB and XPD compared to cells with mutant XPB or XPD. Cells with normal XP...

U of S researchers develop new vaccine candidate against hepatitis C

... will be effective against them. The researchers exposed dendritic cells in vitro to a HCV protein. The cells were also exposed to a strong immune stimulator to increase the immune response and then injected into mice as a vacci...

Some like it hot: Worms at deep-sea vents favor a fiery 45-55°C

...d other thermo-tolerance studies, where scientists exposed individuals to high temperatures for 15 to 30 minutes, as long as it took for half of them to die," says Girguis, assistant professor of organismic and evolutionary biology in Harvard's Faculty of Arts and Sciences. "Unlike many animals found in hot ...

Molecular mechanism may explain how fevers spark seizures

...hat would happen to these receptors when they were exposed to high temperatures. She raised the temperature of cells expressing the mutant receptors to 40 degrees Celsius, simulating a "fever" of 104 degrees Fahrenheit, and she found that the receptors disappeared from the cell surface. Fewer inhibitory GA...

Computer simulation hints at new HIV drug target

... may be closed most of the time can be transiently exposed by an imperceptible atomic shudder. "This 'foot in the door' mechanism of drug binding and action is a relatively new way of thinking about things, arising from the greater appreciation of proteins as dynamic molecular machines," McCammon explained. ...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

... may be closed most of the time can be transiently exposed by an imperceptible atomic shudder. "This 'foot in the door' mechanism of drug binding and action is a relatively new way of thinking about things, arising from the greater appreciation of proteins as dynamic molecular machines," McCammon explained. ...

Genetic mutation linked to West Nile virus infection

...y resistant to HIV infection, even when repeatedly exposed to the virus. This resistance was the theoretical basis for the development of therapeutic CCR5 inhibitors, several of which are now in clinical trials, for the treatment of patients with HIV. CCR5 seemed like an ideal drug target, as people missin...

Higher carbon dioxide, lack of nitrogen limit plant growth

...rassland plants in 296 field plots. The plots were exposed to both ambient and elevated carbon dioxide levels, and varying levels of nitrogen. The study was designed to document plants' ability to grow and flourish in nitrogen-depleted soil, which, scientists believe, will become more common as atmospheric ...

U-M researchers take new approach to defeating Gram-negative bugs

...evels of bile salts to which the bacteria would be exposed in the human gut. Besides differing in how they respond to Gram's coloring test, Gram-positive and Gram-negative bacteria look different. Gram-positive cells are smooth on the outside, while Gram-negative cells have sugars and carbohydrates on the o...

Yale researchers find environmental toxins disruptive to hearing in mammals

...so speculated that whales and other marine mammals exposed to TBT would have altered sound localization abilities. The present findings confirm that their hearing is altered in mammals. "Since many marine mammals use echolocation or sonar to get around, this could be contributing to whales and dolphins beac...

Hopkins researchers discover genetic switch that turns off an oxygen-poor cell's combustion engine

...ally altered to lack HIF-1. When the investigators exposed these so-called HIF-1 null MEFs to hypoxic conditions, the cells were unable to activate PDK to block mitochondrial function. This showed that HIF-1 is required to activate PDK. The team then genetically engineered HIF-1 null MEFs and forced PDK to...

Contaminants linked to sturgeon decline in Columbia river

..., so any population of fish at any one site can be exposed to a myriad of substances." The OSU researchers say it is difficult to estimate the numbers of sturgeon in the Columbia, but there has been a noticeable decline in the number of young fish, indicating productivity is poor, especially in the impounde...

New 'self-exploding' microcapsules could take sting out of drug delivery

...capsules, which release their drug cargo only when exposed to ultrasonic waves or another external trigger, the new system relies on internal mechanisms to do the same job. Each of the new microparticles features a biodegradable gel core that is surrounded by a lipid membrane. As the gel biodegrades, pressur...

Manchester scientists create new bio-gel for 3D cell culture

...aneously assemble into nanometer sized fibres when exposed to physiological conditions, to create a fibrous gel-like structure in which cells can be cultured. Because thismaterial is made up of 99% water and is pH neutral, it is compatible with biological systems. "By using dipeptide building blocks instea...

Study may help slay 'Yellow Monster'

...her team are the first to show that when cells are exposed to uranium, the uranium binds to DNA and the cells acquire mutations. When uranium attaches to DNA, the genetic code in the cells of living organisms, it can change that code. As a result, the DNA can make the wrong protein or wrong amounts of protei...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

... laboratory model, human ovarian cancer cells were exposed to each drug. "In platinum antitumor chemistry our objective is to design and develop complexes acting by new mechanisms of action," said Nicholas Farrell, Ph.D., professor and chair in the Department of Chemistry at VCU, and lead author of the stu...

Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients

...ted them with a range of doses of ceftriaxone, and exposed them to Tat or gp120. They found that the antibiotic protected the neurons against both HIV proteins. The dose of ceftriaxone needed for protection was well within the range currently used for treatment of bacterial infections. "These results indica...

Albatross study shows regional differences in ocean contamination

...ontaminant levels," Finkelstein said. Humans are exposed to the same contaminants when they eat seafood, she added. "It is important to realize that these contaminants have long-term effects, and we are only beginning to understand many of the subtle effects they can have, such as endocrine disruption an...

Vegetables inhibit growth of prostate cancer in mice with human tumors

...ontaminant levels," Finkelstein said. Humans are exposed to the same contaminants when they eat seafood, she added. "It is important to realize that these contaminants have long-term effects, and we are only beginning to understand many of the subtle effects they can have, such as endocrine disruption an...

1 2 3 4 5 6 7 8 9 10