Prions rapidly 'remodel' good protein into bad, Brown study shows
... form. These results were confirmed in a series of experiments using different biochemical and genetic techniques. Because proteins can't replicate like DNA and RNA ?the genetic material in bacteria, viruses and other infectious agents ?the research helps explain the puzzling process of how prions multiply and ...An essential regulator of body weight revealed
...to POMC neurons to stimulate appetite. But genetic experiments designed to tease out exactly how NPY/AgRP neurons...mportant. He and his colleagues have already begun experiments to test specific molecules that might contribute to their essential role. ...Research casts doubt on circulating stem cells
... so far been interpreted over-optimistically." The experiments with green-fluorescent nerve cells would seem to be one such case: "The bone marrow-derived cells have probably migrated from the blood into the brain where they do not change into nerve cells but blend with the neurones that already exist there." In...New antibody shows promise as cure for anthrax
... toxin and the anthrax bacteria. In two separate experiments conducted in SFBR's biosafety level 4, maximum containment laboratory, researchers placed anthrax spores in the nasal passages of guinea pigs, mimicking exposure to inhalation anthrax. The doses were 250 to 625 times what would ordinarily be lethal t...K-State professors discover enzyme responsible for creation of a beetle's hard shell
...icles and to perform cuticle protein cross-linking experiments that are catalyzed by insect laccase, Kramer said. KU scientists will test the strength of the synthetic cross-linked biopolymers that are created. This could be used for the development of strong, lightweight materials. Both Beeman and Kramer also ...Displaced songbirds navigate in the high Arctic
... cues alone or in combination with solar cues. The experiments suggest that, in contrast to what would be predicted by a simple genetic-migration program, both adult and juvenile white-crowned sparrows possess a navigation system based on a combination of celestial and geomagnetic information to correct for long...Solexa and collaborating scientists illuminate the small RNA component of the transcriptome
...tate public access and use of these data." "These experiments underscore the importance of studying the entire genome for evidence of small RNA activity. The newly discovered small RNAs that match to genes are exciting, but so are those that derive from relatively featureless regions between genes," added Pamel...New factor implicated in allergy and asthma attacks
...years conducting extensive test-tube and lab-mouse experiments to prove the paradigm-shifting "two-signal concept...ng reactive oxygen species in cell culture and, in experiments with mice, in their lungs and airway lining fluid. The resulting oxidative stress, Boldogh said, alm...Plants reveal a secret and bring researchers nearer a cleaner future
...s Pieter Glatzel, head of beamline ID26, where the experiments were carried out. The researchers measured the fluorescence from the sample that is emitted after excitation with X-rays. They flashed the sample with a laser and registered the change using X-ray fluorescence every 10 microseconds to find out how ...Sudden change in social status triggers genetic response in male fish, study finds
...he PloS Biology study is the latest in a series of experiments from the Fernald lab on the behavior of Astatotilapia (Haplochromis) burtoni--one of hundreds of cichlid species that inhabit Lake Tanganyika and other freshwater lakes in East Africa. Like all cichlids, A. burtoni lives in a hierarchical social syst...New vaccine platform may fight infections with causes from influenza to bioterrorism
...ble to bypass the need for T cells. A series of experiments helped identify the two key components of the expe...stis as a whole. In perhaps the most significant experiments the researchers conducted, mice depleted of CD4+ T cells received the combination CD40L-kexin vaccin...Student scientists create living bacterial photographs
...unicate with each other. They're also working on experiments using a laser to turn on and off single cells, which would give them great control. "If we can hit the cell with a laser, we can manipulate their biology without needles or syringes," says Tabor. "We just turn it on or off with light." Other studen...University of Delaware researchers develop cancer 'nanobomb'
... go home," Panchapakesan said. While these initial experiments are on breast cancer cells, he is also working to extend his method to prostate cancer and pancreatic cancer. He also foresees nano-bio-robots or nano-surgical tools that can be placed inside the body to remove tumors in areas previously inaccessi...Cyberkinetics, Case to develop system to help restore extremity function
... of FES systems, computers, and robotic devices in experiments using monkeys. Together, the team has the potential to advance cortical interfaces into the world of restorative rehabilitation as a "brain-body interface" (BBI). About the BrainGate TM System The BrainGate Neural Interface System is a proprieta...Fish evolve a longer lifespan by evolving a longer reproductive period, researchers find
...ism's lifespan. The researchers conducted their experiments by comparing life-history traits in 240 guppies they retrieved from high- and low-predation streams in mountains in Trinidad. In their analysis, they divided the life history into three non-overlapping segments: the age at maturity (birth to first re...Anti-cancer drugs may hold promise for premature aging disorder
... in a mouse model validate the results of the cell experiments and translate into improvements in the animals' conditions, a clinical trial of FTIs in children with progeria may begin as early as next spring, researchers said. Dr. Collins and his colleagues discovered in April 2003 that mutations in the lamin ...New neurons take baby steps in the adult brain
In experiments with mice, scientists from Johns Hopkins' Institut...e other adult neurons," he says. The researchers' experiments were done on a part of the mouse brain called the dentate gyrus, which is thought to be involved in ...Double trouble: Cells with duplicate genomes can trigger tumors
...s contain 44 pairs plus the sex chromosomes. "Our experiments test an idea that's been percolating along among cell biologists for many years but was never really embraced by the cancer community," says Pellman. "We set up this experiment to test it in a real cancer setting." A companion paper being published ...Researchers: Treated wood poses long-term threat
...em. A mathematical model based on the researchers' experiments estimated that between 20 and 50 tons of arsenic may have leached into construction and demolition landfills in Florida before 2000, with an expected increase of between 350 and 830 tons of the heavy metal by 2040. Florida law does not require that ...Scientists observe how a close bond activates the immune system
... Dr. Dustin's group is now conducting additional experiments to see if dendritic cells actively present proteins to T cells in patterns that stimulate the periphery of the bull's eye in the immunological synapse, using molecular organization to provide information about the precise nature of the threat associa...