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Tag: "experimental" at biology news

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

...s in the Cancer Immunobiology Center developed the experimental vaccine for the deadly toxin as an outgrowth of their cancer-therapy work. Dr. Vitetta, Dr. Joan Smallshaw, assistant professor in the center, and their colleagues showed in pre-clinical studies that the subunit of the ricin toxin used to make RiVax ...

UCSD study finds anthrax toxins also harmful to fruit flies

...ns in other diseases or biological processes. Such experimental tools could accelerate progress in various areas of biomedical research. Guichard first conceived this study in 2002, to apply her experience in molecular genetic studies to research that had medical application. At that time, after the spate of an...

Stem cells from muscles can repair cartilage

...d can lead to degenerative disease. Treatments and experimental approaches to repair this articular cartilage have achieved limited results, but currently there is no method to fully restore this type of injured cartilage. Tissue engineering involving the delivery of therapeutic proteins to the injured site is a ...

Infection 'alarm' yields clues to immune system behavior

...makers. "Models like this are a wonderful tool for experimental drug testing," Levchenko said. ...

Simple idea to dramatically improve dengue vaccinations

...unodominance, and when we compare our results with experimental data from Dengue vaccination trials, they match quite closely. There may be other factors at work, but we appear to be explaining a significant portion of the effect that occurs in Dengue immunodominance." Immunodominance is also a problem for resea...

H5N1 avian flu virus vaccine induces immune responses in healthy adults

...a clinical trial demonstrate that high doses of an experimental H5N1 avian influenza vaccine can induce immune responses in healthy adults. Approximately half of those volunteers who received an initial and a booster dose of the highest dosage of the vaccine tested in the trial developed levels of infection-fig...

Canine cancer vaccine program shows early promise

...s diagnosed with melanoma. Though it is still an experimental treatment, dog owners from all over the nation have wanted to participate in the study, on the remote chance that this would help their pet. After promising results from work done in collaboration with cancer specialists from Arizona, California, an...

Mouse study reveals human X-SCID gene therapy poses substantial cancer risk

...ent, Woods says. "This indicates that preclinical experimental treatments involving transgenes should include long-term follow-up before entering a clinical trial," says Woods. But, more fundamentally, the Salk study suggests that replacement of a gene that serves multiple functions in the body may be much more...

Genetic and environmental influences on alcohol consumption among rhesus monkeys

...al environmental effects' not accounted for by the experimental treatments and covariates identified in the study," said Lorenz. In earlier research, Lorenz and his colleagues had discovered that early rearing experiences (mother- versus peer-reared) during the first several months of life among infant rhesus ...

New drug could reduce tissue damage after heart attack

...that human CRP increases the severity of damage in experimental models of heart attack and stroke. This first ide...and blocks the tissue damaging effect of CRP in an experimental heart attack model. Professor Mark Pepys, of the UCL Centre for Amyloidosis and Acute Phase Protein...

A link is found between morphine addiction and the tendency to explore

A team of researchers from the UAB has found experimental evidence in rats showing a link between addiction to morphine and the tendency to explore perseveringly. This is the first time a direct relationship has been found without other psychological characteristics, such as anxiousness, that might affect r...

Flesh-eating bacteria escape body's safety net

...spreading infection when injected into the skin of experimental mice." The critical role of the DNA-degrading Strep enzyme was confirmed by cloning the corresponding gene into a normally non-pathogenic bacterial strain. Addition of the single gene allowed these bacteria to degrade DNA, escape neutrophil killing...

A surprising pair of proteins help make healthy eggs

...ell lines of ovarian granulosa cell origin. In the experimental line, the level of TAF4b was increased. Berkeley researchers compared these lines and were able to identify the cooperative role of TAF4b and c-Jun, as well as the activation of the network of genes they control. In parallel, Brown scientists studie...

Experimental TB drug effective against resistant and latent mycobacterium tuberculosis

An experimental tuberculosis drug may be effective against not only multi drug-resistant forms of the disease but could also be the first compound to treat the latent stage of infection as well. Researchers report their results today at the 2006 ASM Biodefense Rese...

Genome sequencing is for ecologists, too

... eager to exploit genomic technologies and genomic experimental approaches that have already revolutionized research in the human health sciences, with the goal of diagnosing the state of aquatic environments. Despite their common name, water fleas are not insects but crustaceans, like lobsters and crabs. Daphni...

Lack of a key enzyme dramatically increases resistance to sepsis

...al infection and septic mortality. "Without the experimental model of peritonitis perfected by John Mathison from Scripps Research, we would not have been able to differentiate between the two mouse phenotypes," Ulevitch said. "Because of his work, we were able to use a surgically implanted stent in the colon ...

Study suggests that publicly available genome data may contain small but significant errors

... assembly. The authors show that with appropriate experimental conditions, array hybridization data can be used to establish a physical distance between unique arrayed probes--a sequence of DNA which in this case was 70 base pairs long. Each of the 70 base pairs is unique in the target organism's genome and serv...

Born with a love of speech

...os and colleagues developed a painstaking two part experimental procedure to separate out possible in-utero exposure from innate predisposition. At the core of the studies is a unique set of complex speech analogues designed to be as close to speech as possible, without being words. This provided a stringent tes...

New hybrid virus provides targeted molecular imaging of cancer

...rve as a vehicle for targeted delivery of genes to experimental tumors in mice and to the tumors' blood vessel supply, providing a strategy for finding tumors and genetically marking them for imaging on a clinic-ready body scanner. The AAVP hybrid combines the ability of the bacterial virus to target specific ti...

How 'hot' emotional brain interferes with 'cool' processing

...the dorsal system and impaired performance. "The experimental design mimicked the kind of distraction people experience in everyday life," Dolcos added. "For example someone driving on a highway, attempting to pay attention to the driving task might encounter an emotional distracter such as an accident. As ever...

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