Two designer drugs hit same lung cancer target, but only one is effective
...cancers responded to Erbitux. Janne says that the experiment told the scientists something new about the biology of the EGFR mutation in NSCLC. "The lesson is, to inhibit the mutant receptor, you need to inhibit the domain of the EGFR molecule that lies within the cell, as opposed to the extracellular domain,"...Monkeys understand numbers across senses
...said Brannon, the researchers decided to design an experiment that used socially relevant stimuli. "Our approac...at the monkeys could not learn anything within the experiment and instead were demonstrating their spontaneous numerical abilities. Other aspects of their experim...Scientists create digital bacteria to forge advances in biomedical research
...ame way. Sometimes, though, conducting the actual experiment would be undesirable. Preparing for a bioterrorism attack is one example. "You can actually try to simulate dangerous experiments," said Cluzel, an Assistant Professor in Physics. "For instance, if you mix a pathogenic strain with a friendly strain, ...High carbon dioxide levels spur Southern pines to grow more needles
...d at the Free-Air Carbon Dioxide Enrichment (FACE) experiment in Duke Forest, a near-campus research reserve. A...gen on needle volumes because one area of the FACE experiment had been fertilized during her study period. "The viability of leaf area enhancement is really drive...Molecular mechanism of feather formation found
...m the barbs. Harris and colleagues used a similar experiment to test whether Shh could up-regulate its own expression during barb formation, and found that it could. Similarly, they found that regional expression of Shh led to detectable up-regulation of Bmp2 in feather buds as they first grew. The underlying...Freeze-dried mats of microbes awaken in Antarctic streambed
An experiment in a dry Antarctic stream channel has shown that a...s add water." McKnight gave a presentation on the experiment at the Ecological Society of America's 90th Annual Meeting held Aug. 7 to Aug. 12 in Montreal. The...Tropical Deforestation affects rainfall in the U.S. and around the globe
...general circulation model and that reproducing the experiment with other computer models using different atmospheric variables would be beneficial. Current research is attempting to answer why deforestation has such a major influence on precipitation patterns during respective seasons. ...Picky female frogs drive evolution of new species in less than 8,000 years
...me back together, have got a separate evolutionary experiment going on. And some of those pan out and some don't. But if they head off in different directions, the products themselves can be new species. And I think that's kinda cool. It gives us a mechanism for very rapid speciation." ...Study shows big game hunters, not climate change, killed off sloths
...thern Mexico to southern Brazil, he said. Such an experiment might be similar to the one that involved restoring bison, once native to Florida, to Paynes Prairie Preserve State Park near Gainesville, Steadman said. "With the work we're doing, especially on islands, to reconstruct which kinds of plants and anim...An essential regulator of body weight revealed
...dents. So I would predict that if you could do the experiment in humans, this result would be the same, because the circuits are the same." And he speculates that mutations in human genes that affect the survival of these neurons or their ability to respond to hormonal signals could alter eating behavior and bo...MicroRNAs have shaped the evolution of the majority of mammalian genes
...ew study, scientists in the Bartel lab designed an experiment that zeroed in on these nonconserved targets. Grim...microRNAs, which latched on without a problem. The experiment proved that a matching sequence is generally sufficient to disrupt mRNA's ability to make protein. ......possibilities, Romo and his colleagues designed an experiment in which they touched the monkeys' fingertips with a vibrating but painless probe for varying lengths of time. The monkeys were first taught to respond to varying vibration frequencies; in a training session, the scientists touched the monkeys twice ...Scientists develop nanotech-laser treatment that kills cancer cells without harming healthy tissue
...cted to diseased cells with folate receptors. The experiment worked as predicted. Most of the folate-coated nan...rs at Rice University recently conducted a similar experiment on mice with cancerous tumors. Instead of carbon nanotubes, the Rice team injected the tumors with g......e and colleagues believe their large-scale natural experiment demonstrates a wolf-driven cascade effect. Only wolves were completely eliminated from the study area and subsequently recovered. Bears and other large carnivores were never completely extirpated. In addition, the researchers traced elk deaths in the...Sudden change in social status triggers genetic response in male fish, study finds
...male becomes infertile. "Previously we did an experiment in which we moved the subordinate male out of the ...nly disappear? To find out, Burmeister designed an experiment in which the dominant male was surreptitiously removed from the tank after dark. "Cichlids have grea...Wright bros. upstaged! Dinos invented biplanes
...plane wing configuration was probably a very first experiment in nature," says Chatterjee of the early flying technique, which was also used by another feathered dinosaur from China, Pedopenna, he said. Archaeopteryx achieved fully powered flight with monoplane configuration, as its wing became even larger than...NJIT study shows nanoparticles could damage plant life
...ina suspended in water. The control portion of the experiment was treated only with water, and the authors observed the experiment for seven days. During that time, they measured the differences in the growth of the plants' roots, ...Double trouble: Cells with duplicate genomes can trigger tumors
...e cancer community," says Pellman. "We set up this experiment to test it in a real cancer setting." A companion paper being published simultaneously in Nature by Randy King and colleagues at Harvard Medical School reports that tetraploid cells may arise more frequently than had been thought. According to Pellm...Researchers know what you were about to say; fMRI used to detect memory storage and retrieval
...ing shift in brain activity. "The results of this experiment suggest that when we think back to the past, each detail we remember triggers another, until the memory returns completely," Polyn said. "In that sense, memory retrieval is like revisiting the past; brain patterns that are long gone can be revived b...A counterintuitive experiment has resulted in one of the longest recorded life-s...o starvation. The long-lived organisms in Longo's experiment showed extraordinary resilience under stress. "We hit them with oxidants, we hit them with heat," L...