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Tag: "excision" at biology news

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...ther reduced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterations known as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, Ph.D., of the Columbia University Mailman School of Public Health in New York, and colleagues analyzed cell lines generated from ...

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

... damage by a DNArepair mechanism called nucleotide excision repair. Insufficient repairof UV-induced DNA damage, which for example may occur after excessiveunprotected sunbathing, can lead to cellular death ?recognized assunburn of the skin ?and may cause permanent changes in the DNA(mutations) that ultimatel...

Jumping gene helps explain immune system's abilities

...ss, known as V(D)J recombination, is similar tothe excision of jumping genes, but none had matched one of itscharacteristic oddities: As the unwanted DNA is being removed, theremaining DNA forms a tiny loop.Unexpectedly, when Hermes is being cut out of the DNA, the leftover DNAalso forms a hairpin loop, tempo...

UCSD Discovery Shows How Embryonic Stem Cells Perform 'Quality Control' Inspections

...ss, known as V(D)J recombination, is similar tothe excision of jumping genes, but none had matched one of itscharacteristic oddities: As the unwanted DNA is being removed, theremaining DNA forms a tiny loop.Unexpectedly, when Hermes is being cut out of the DNA, the leftover DNAalso forms a hairpin loop, tempo...

New therapy for HIV/AIDS eliminates needles and excessive toxicity

...ss, known as V(D)J recombination, is similar tothe excision of jumping genes, but none had matched one of itscharacteristic oddities: As the unwanted DNA is being removed, theremaining DNA forms a tiny loop.Unexpectedly, when Hermes is being cut out of the DNA, the leftover DNAalso forms a hairpin loop, tempo...

Gene sequencing explains bioremediation 'bug'

...ss, known as V(D)J recombination, is similar tothe excision of jumping genes, but none had matched one of itscharacteristic oddities: As the unwanted DNA is being removed, theremaining DNA forms a tiny loop.Unexpectedly, when Hermes is being cut out of the DNA, the leftover DNAalso forms a hairpin loop, tempo...

Scalpel-free surgery could reduce risk of HIV and hepatitis exposure for health care workers

...of infection - lymph-node biopsy, soft-tissue-mass excision and abscess-drainage cases - were often assigned to the most inexperienced surgeons-in-training, placing them at greatest risk. "Sharpless surgical techniques combined with traditional precautions and early education for surgery trainees are the mos...

Carnegie Mellon University research reveals how cells process large genes

...," Lopez said. "These steps involve the sequential excision of smaller subfragments. Our work also indicates that most recursive splicing events leave no clues in the final mRNA. This is why they have not been detected before now." These previously undetected events could have profound implications for pred...

Reversal of role for a viral protein associated with the development of lymphoma

...," Lopez said. "These steps involve the sequential excision of smaller subfragments. Our work also indicates that most recursive splicing events leave no clues in the final mRNA. This is why they have not been detected before now." These previously undetected events could have profound implications for pred...

Plant defenses prompt bacterial countermeasure in the form of 'island' DNA excision

...DNA on either side of the island, resulting in the excision of the entire island from the genome. The researchers found that this excision occurs in response to a so-called hypersensitive resistance reaction by the plant . The specific pla...

Terahertz imaging may reduce breast cancer surgeries

... to ensure complete tumor removal at breast cancer excision is introduced in the May issue of Radiology. Rese...rgeon to analyze tissue samples during the initial excision procedure. Terahertz light is located between the infrared and microwave portions of the electromag...

Enzyme crystal structure reveals 'unexpected' genome repair functions

...n that is critical to transcription and nucleotide excision repair (NER), as well as other cell processes. "...ion relationships for transcription and nucleotide excision repair." Research Associate Li Fan of Scripps Research, the first author of the study, adds, "We we...

Buildup of damaged DNA in cells drives aging

...t. Defects in one DNA repair mechanism, nucleotide excision repair (NER), causes xeroderma pigmentosum, a rare disease in which people have a 2,000-fold increased risk of skin cancer from sun exposure. When the investigators obtained cells from the boy and tested them for NER activity, they found almost no...

ASU researchers test antibacterial effects of healing clays

..., been largely confined to amputations or surgical excision of the infected sites." This means if the clays are antibacterial in nature and the locus for that activity can be isolated, they may represent a new form of treatment, one that goes beyond the capacity of existing antibiotics. "And they could be ...

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