UCSD team discovers specialized, rare heart stem cells in newborns
The first evidence of cardiac progenitor cells ?rare, specialized stem cells located in the newborn heart of rats, mice and humans ?has been shown by researchers at the University of California, San Diego (UCSD) School of Medicine. The cells are capable of differentiat...New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
...and 75 percent had a complete response, meaning no evidence of cancer remained. More than three-quarters of patients with a complete remission were disease-free after five years. Results of the study appear in the Feb. 3 New England Journal of Medicine. "The results of this treatment, which essentially take...Family trees of ancient bacteria reveal evolutionary moves
... with ways to deal with the UV light ?and there is evidence that they made UV-absorbing pigments ?or find ways of growing under sediments to avoid the light." To study the evolution of Cyanobacteria, Blank drew up a backbone tree using multiple genes from whole genome sequences. Additional species were added...Gene therapy for Parkinson's disease moves forward in animals
...inson's Research. "This is additional experimental evidence that suggests that it can be a promising approach to this disease using in vivo gene therapy, which is very applicable to humans. It even presents theoretical reasons that might solve some of the safety issues that have been raised about GDNF. But ma...Scientists find fossil proof of Egypt's ancient climate
...ple were coming to the lake," said Smith. "Genetic evidence suggests that 100,000 to 400,000 years ago was a c...nuscule 0.7 of a millimeter per year, but there is evidence that the rainfall amounts in the region have gotten up to as much as 600 millimeters per year, "not ...How an AIDS-Related Cancer Unleashes Inflammation
...d. In cell culture studies, the researchers found evidence of an “activation loop,?by which kaposin B activation of MK2 promotes even further MK2 activity by other proteins. The over-production of cytokines resulting from kaposin B's binding to MK2 creates inflammation that in turn activates the regulatory p...Bone Density Recovers After Teens Stop Injected Contraceptive
...women in the previous study. “This study provides evidence that DMPA use by adolescents adversely impacts [bone mineral density] at key anatomical sites,?the study authors wrote. “However, these results in teens and those from our previous cohort provide reassurance that bone loss is regained, even in younge...Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
...s is first author on the study. "There is growing evidence that there may be times in a woman's life when exp...ational studies, they are provocative in providing evidence both of the importance of early exposures and of the potential importance of an environmental agent ...Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
...DNA sequence data. GenRate balances probabilistic evidence derived from different sources and outputs scores (log-likelihoods) for each gene model, enabling the estimation of false-positive and false-negative rates. The model has a number of local minima that is exponential in the length of the DNA sequence ...Antibiotic might fight HIV-induced neurological problems
...infection -- five of the six untreated monkeys had evidence of moderate or severe encephalitis and much more physical evidence of damage to brain cells, the researchers report. "The infection in the animal model is predictable...Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
...on (APA). The findings fit into a growing body of evidence that even a one-time infection can potentially permanently change physiological systems, a phenomenon called "perinatal programming." Understanding how infection in newborns can disrupt memory in immune-challenged adults may help scientists to unde...Effective Cancer Treatments Follow The Clock
...nockout animals' immune system B cells, they found evidence that the activity of the Clock and Bmal1 genes determined the cells' sensitivity to CY. “Thus, this paper gives us specific mechanistic insight into the role of circadian rhythms in sensitivity to such drugs,?said Takahashi. “This is not some vague ...How the environment could be damaging men's reproductive health
Two Scandinavian studies have provided further evidence that environmental factors could be affecting men's reproductive health. The studies, published online today (Thursday 28 April) in Europe's leading reproductive medicine journal Human Reproduction, suggest that environmental pollutants could be cha...Surprising findings reported about iron overload
...of mutations in a gene, called the HFE gene, which evidence suggests regulates iron absorption. "Hemochromatosis and iron overload are easily treatable if diagnosed early, but the simple blood test that could detect these conditions is not performed as part of routine medical exams," said Acton. Delaying tre...Variation in women's X chromosomes may explain differences among individuals, between sexes
...rst assumption, when, in the late 1980s, the first evidence came to light that some portion of the genes on the second X chromosome in women remained active. The new work extends that earlier finding to the full set of X-linked genes and also further reveals that individual women exhibit extensive difference...UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders
...ls as tightly linked," Gasson said. "More and more evidence suggests that cancer is a stem cell disease. Many of our current therapies are not effective because they don't target the cancer stem cells. Our experience with gene medicine and the GMP facilities will make it easier for us to translate our basic s...Wisconsin researchers identify sleep gene
...'s team also conducted EEGs on the flies and found evidence of the same electrophysiological changes occurring during sleep and wakefulness as in humans. "The electrical changes in humans look different that they do in flies because our brains are organized differently," Cirelli says. "But the EEGs showed el...Norovirus, AIDS vaccine and Hepatitis Virus
...control subjects died. "The results showed strong evidence that this type of vaccine could prevent AIDS and established that a DNA vaccine, such as this one, could be used alone, without the need for booster doses with viral proteins, for large-scale immunization programs," say the researchers. (D.K. Singh,...Camera Traps Catch Eye of the Tiger
...ed a track survey, in which they attempted to find evidence of the animals in a specific area. This information was used to determine where to set up camera traps, armed with infrared sensors triggered by movement. WWF put 30 camera traps in the forests -- one per tiger home range (about 40 square miles) -- ...Chemists identify immune system mechanism for methamphetamine binges
...mists at The Scripps Research Institute have found evidence in laboratory studies that the immune system may be able to recognize methamphetamine and boost tolerance to the drug through an unusual vaccine-like mechanism. Their finding, if confirmed in human studies, could help explain why chronic users go on ...