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It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...Hopkins. "In the mice with a double dose of IGF2, everything is pretty normal except for the extra precursor cells," says Christine Iacobuzio-Donahue, M.D., assistant professor of pathology and oncology. "But when the genetic mutation is present, too, we found a clear cost for what otherwise appears to be a be...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...ise or drop in response to glucose levels, keeping everything in balance. But diabetes is a complex metabolic disorder with numerous players such as high levels of blood glucose, cholesterol and other lipids. "The challenge is to figure out which factors are a primary cause of diabetes and which are a consequen...

Ecological destruction fuels emerging diseases

...d 250,000 species of plants and animals, including everything from viruses to jaguars. For his part, Dr. Brooks has looked for parasites in more than 4,000 individuals from species ranging from frogs to deer. So far, he has found more than 5,000 different types of these often microscopic hangers-on and created...

Dinosaur DNA? New Patent Covers Degraded DNA recovery

... samples, and could allow scientists to reassemble everything from prehistoric, extinct animals to unsolved crime scenes. "This discovery, when properly applied by our scientists, brings us closer to our goal of reconstructing genetic history. We now have the picture on the outside of the puzzle box, and by st...

Experiments provide proof of how traveling in groups protects insects

...d form teeming, hungry islands of life that devour everything in their path that's edible. Some spectacular marching packs stretch several miles wide and extend 10 miles or so in length. And they can travel a mile or so a day. Why such groups of insects form has mystified humans for thousands of years. One fir...

Experiments provide proof of how traveling in groups protects insects

...d form teeming, hungry islands of life that devour everything in their path that's edible. Some spectacular marching packs stretch several miles wide and extend 10 miles or so in length. And they can travel a mile or so a day. Why such groups of insects form has mystified humans for thousands of years. One fir...

Plants defy Mendel's inheritance laws, may prompt textbook changes

...tells us that's just not possible. This challenges everything we believe. "We've done a lot of experiments, des...e hothead-containing plants keep a cryptic copy of everything that was in the previous generation, even though it doesn't show up in the DNA, it's not in the chro...

Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

...e subunit sequence of every gene in the genomes of everything from malaria pathogens and mosquitoes to mouse and human. Databases of genomic information have been combined with databases that list the precise subunit sequence of proteins as well. Cross-species DNA and protein comparisons have become routine for...

Supercomputer Dedicated To Bioengineering, Computational Biology Installed

...omputer cluster on campus, will be used to analyze everything from the behavior of protein molecules and subcellular structures such as nerve synapses and cardiac muscle cells, to multicellular tissue and the whole heart. Bioengineering professor David Gough (left), principal investigator of NBCR Peter Arzberg...

Vampire bats keep out of trouble by running

... subjects broke into a run. "They just seem to do everything a little differently from the general bat rule," Riskin says about what he refers to as the "cute, adorable, big-eyed and family-oriented" vampire bats. Not only are vampire bats unusual because they run, but also in the way that they power their ga...

Fleshing out the genome

... are the workhorses of the cell, playing a role in everything from energy transport and metabolism to cellular communication. This new ability to rank hypothetical sequences according to their likelihood to encode proteins "will be vital for any further experimentation and, eventually, for predicting biologica...

A frog's life is food for thought

...m up and fed them to find out how quickly they got everything going again." Ms Cramp's results show that animals can maintain the functional capacity of the gut during aestivation despite significant energetic cost, allowing them to digest food as soon as they resurface from aestivation. "Despite the marked d...

Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive

...e probably integrates huge amounts of information, everything from early personal memories to one's personal notions of beauty. Then, this brain region (and related regions of the basal ganglia) helps to direct one's actions toward attaining one's goals. For neuroscientists," she said, "these findings about the...

Revolutionary nanotechnology illuminates brain cells at work

...ll activity in mammalian brains. It is involved in everything from learning and memory to mood and perception. Too much glutamate is believed to contribute to conditions such as Alzheimer's and Parkinson's disease. The research is published in the May 30-June 3 on-line early edition of the Proceedings of the Na...

Small species back-up giant marsupial climate change extinction claim

Thinking small in a time when everything was big has helped Queensland researchers to unearth new evidence that climate change, instead of humans, was responsible for wiping out Australian giant marsupials or megafauna 40,000 years ago. Instead of only excavating 'trophy specimens' such as...

Shift of weather patterns necessitates rethinking of reforestation methods

... bare root plantings after two years. "And we did everything right planting the bare root seedlings," Taylor said. "Doing everything right" meant meticulous attention to care of the bare root seedlings, soil moisture at planting time...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

... sheds light on an area of research fundamental to everything from the normal processes that govern the everyday life of human cells to the aberrant mechanisms that underlie many diseases, including cancer and septic shock. The discovery concerns tiny fragments of RNA known as microRNA and their relationship t...

Confocal imaging promises early detection of skin cancer

...to reduce the manufacture costs ?by stripping away everything not needed for skin diagnosis, redesigning optical components and producing a user-friendly design. “We can cut these costs by a factor of ten, resulting in a 20,000-euro machine that is affordable for many outpatient centres.?/p> Trials at two u...

Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics

... between the solution and the electrodes. “Almost everything we know about charge transfer in molecules is based on measurements made with the molecules suspended in solution,?Lindsay says. “Chemists have understood for a while that the solvent itself plays a major part in charge transfer processes ?the ions i...

Currents could disrupt ocean food chain

...ood web," Schmittner said. "They ultimately affect everything from zooplankton to the larger fish that people consume." The Atlantic Conveyer current has the strongest impact in the North Atlantic, but it is a global phenomenon, Schmittner said. Surface waters from the Pacific Ocean, the Indian Ocean, the Arab...

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