Tag: "even" at biology news

Wisconsin scientists grow critical nerve cells

...motor neurons, says Zhang. The goal proved elusive even in simpler vertebrates such as mice, whose embryonic stem cells have been available to scientists for decades. One reason scientists have had difficulty making motor neurons, Zhang believes, may be that they are one of the earliest neural structures...

Man and mouse share genome structures

...lar patterns along equivalent chromosomal regions, even where the underlying DNA sequences are different. Bernstein and Schreiber began to develop the analytical techniques several years earlier, working with the smaller yeast genome. To investigate the much larger human genome, they collaborated with Af...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...proteins (HDL, or "good" cholesterol) and may have even stronger adverse effects than do saturated fats. The researchers report that when activated by harmful fats, PGC-1beta alters liver metabolism through a cascade of biochemical signals. The result is an upsurge in the liver's production of very low-d...

A new mechanism of regulating RNA degradation

...d now it seems that regulation at the RNA level is even more complex than we first imaginated... As any ...ew what Staufen1 did in human cells," said Maquat, even though its presence in mammalian cells has been recognized for several years. "We were surprised to...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...d now it seems that regulation at the RNA level is even more complex than we first imaginated... As any ...ew what Staufen1 did in human cells," said Maquat, even though its presence in mammalian cells has been recognized for several years. "We were surprised to...

Spleen may be source of versatile stem cells

...ls andalso suggests they may be able to produce an even greater variety oftissues. The report appears in the January 19 issue of SAGE KE , an online resource on the science of aging from the publishers of the journal Science. "Theremay be a previously undiscovered pocket of primitive stem cells in thesp...

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

...example,with all the interlacing systems. We can't even see a microbialsystem."Sample extraction was a dangerous and delicate operation. In order toaccurately analyze a hot spring's entire microbial community, Spearneeded to collect only about as much material as a pencil eraser.Sediment samples were scoo...

Columbia research lifts major hurdle to gene therapy for cancer

...uce genetherapies that will only kill cancer cells even if the therapy entersnormal cells.As an example, the researchers constructed an adenovirus that carriesthe PEG switch and a toxic protein. The switch and the protein wereconnected to each other so that the deadly protein is only unleashedinside cance...

Priming embryonic stem cells to fulfill their promise

...e learned, add combinations of growth factors, and even add othercells to embryonic stem cells, we may be able for the first time tostudy all the dimensions of the niches required to very specificallycontrol embryonic stem cell differentiation."...

Growth in the sea comes down to a struggle for iron

...m the atmosphere to affect global climate, perhaps even contributing to the onset of ice ages. Martin died...ty guidelines prohibit scientists from boarding or even sharing samples or equipment with a vessel from another country. The American team went to work low...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...impairment was permanent. It couldn't be corrected even when the body caught up to normal weight." Because studies of mice generally are good predictors of human biology, the Joslin study has important implications. "People and their doctors need to understand that prenatal undernourishment makes a perso...

Fox Chase Cancer Center scientists identify immune-system mutation

...mice are unable to generate mature helper T cells, even though their immature T cells carry the CD4 protein," Kappes explained. "Instead, the mutation redirects them to the killer-cell pathway. "Our new study identifies this defect as a point mutation in the zinc finger transcription factor Th-POK. We sh...

Controversial drug shown to act on brain protein to cut alcohol use

...ug use when exposed to the drug of abuse months or even years afterbreaking the habit.In this analysis, the researchers provided alcohol to rats until theyhad become "experienced" daily drinkers. They then withheld alcohol fortwo weeks, which normally leads to greatly increased drinking when whenalcohol i...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...lic acid calledN-glycolylneuraminic acid (Neu5Gc), even though human cells aregenetically unable to make it. In a related paper published November29, 2004 by the Journal of Biological Chemistry (JBC), the Varki grouphas also discovered the exact cellular mechanism by which this occurs. Instudies with one...

Timing is everything: First step in protein building revealed

Timing is everything, it seems, even inscience. A team led by Johns Hopkins scientists ...led and after RNA was added to the mix."We weren't even sure the two fluorescent molecules would be closeenough together to create a FRET signal at all," sa...

Plants respond similarly to signals from friends, enemies

... studied the signals between plants and nematodes, even though the nematode provides no benefit to its host. Root-knot nematodes form feeding cells ?so-called giant cells ?in the plant and later galls or knots on it. "We don't know the precise structure of Nematode factor, but it appears that the nematod...

Scientists detect probable genetic cause of some Parkinson's disease cases

... history of the disease and it is relativelycommon even among those without a family history, it's possible thatdetecting this mutation will help identify people at increased risk forParkinson's disease."About 50,000 Americans are diagnosed with Parkinson's disease eachyear. The disease occurs when certai...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...dd4’s role as a suppressor of Notchwas illustrated even more plainly when the lab showed that inhibitionof Nedd4 results in the upregulation of ligand-independent activationof the Notch pathway.Nedd4’s place in the greater scheme of Notch signaling became clearerwhen the group next turned to examine the i...

Finding Cures For Tropical Diseases: Is Open Source An Answer?

...get cannedbecause no money was to be made with it, even if millions would havebeen saved worldwide. The usual strategy to avoid this fate is to finda drug candidate that affect a "profitable" disease in addition to the"non-profitable" one. PLoS Medecine has an article about a possiblesolution titled "Fin...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...ains Dr. Baker. "Importantly this seems to be true even of the bacteria that are taken up by macrophages in the lung and enter a dormant state ?these are the hardest to attack with drugs." ...

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