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Tag: "evaluate" at biology news

Bioartificial kidney under study at MCG

...lace in intensive care units across the country to evaluate the efficacy of the renal assist device, says Dr. Harold M. Szerlip, MCG nephrologist specializing in acute renal failure and a principal investigator on the study. "If you have renal failure in the ICU, your mortality is extremely high," Dr. Szerli...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...he genetic changes involved in carcinogenesis. To evaluate whether reduced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterations known as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, Ph.D., of the Columbia University Mailman School of Public Health ...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...he APC mutation should be a useful animal model to evaluate the impact of colon cancer prevention strategies, including dietary interventions and targeted drugs. ...

Priming embryonic stem cells to fulfill their promise

...sues. Untilnow, there has been no practical way to evaluate the daunting number ofpossible combinations of these proteins, any one of which could formthe optimal "niche" for a desired type of differentiated cell.In their experiments, the UCSD researchers took advantage of theknowledge that the extracellular m...

Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa

...laire Barnes, PhD. "This clinical trial will help evaluate the potential of Optobionics' ASR® device to provide improved functional vision or to at least slow down the progressive vision loss" says Dr. Schuchard, principal investigator for the project. "There are very few vision rehabilitative options for pa...

Gene variations explain drug dose required to control seizures

...ndings in epilepsy set the stage for scientists to evaluate other conditions in which gene-based diagnostics might help determine the optimum dosage of particular therapies for particular patients, Goldstein said. "For most drugs we know a lot about how and where they act in the body," Goldstein said. "The c...

Scientists collaborate to assess health of global environment

... Millennium Ecosystem Assessment program also will evaluate future scenarios and give governments and institutions direction that Mooney described as a consensus of the scientific community and a synthesis of all available information. Cause for concern "If you look at all the indicators of human well-being...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...dies may eventually lead to other studies that can evaluate an individual's risk for becoming an alcoholic or suffering certain complications from alcohol," he said. Also working on the study were the University of Tennessee Health Sciences; the University of Memphis; the University of Colorado; and the Univ...

Bone Density Recovers After Teens Stop Injected Contraceptive

... current study is among several funded by NICHD to evaluate the impact of DMPA on bone density in women, explained the study’s project officer, Steven Kaufman, M.D., M.S., of NICHD’s Contraception and Reproductive Health Branch. These studies are looking at the effect of DMPA on bone health in women of variou...

LUCA technologies confirms real-time methane generation

...consortia generate methane. The company expects to evaluate specific Geobioreactors and their potential for conversion to methane "farms," both through partnerships with active Operators in the oil and gas industry and potentially on its own. If successfully developed, Luca believes this approach has the pote...

Use of PET can reduce, may eliminate more strenuous drug development trials with animals

...d. With small animal imaging, one can very rapidly evaluate new radiopharmaceuticals using a limited number of animals and possibly eliminate the need for biopsies, extending an animal's life. PET provides a noninvasive view into a person's living biology as it tracks a range of biological processes from met...

Increased risk of osteoporosis associated with gene that one in five people have

...stigated that possibility, so we set up a study to evaluate the relation between bone density and variations of the CYP1A1 gene." The researchers studied 156 women with an average age of 63.5 years who were at least one year past menopause. They analyzed the genetic sequence of each woman's CYP1A1 gene to id...

New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

...led a series of laboratory experiments designed to evaluate an investigational, sustained-release form of a cephalosporin antibiotic. Ultimately the PK/PD approach showed that the difference in drug concentrations in the tissues arising from the standard form of the drug versus the sustained-release variety w...

Turning viruses into allies against cancer

...ve iodine." Future studies should help scientists evaluate the efficacy and optimal delivery system of their radio-virotherapy vector. "We expect this work will take another two years before this technology will be available for testing in patient studies," said Blechacz. ...

Red delicious, Northern Spy apples have most antioxidants, chemists find

...eagues used three different laboratory measures to evaluate polyphenol activity in apples that are popular in Canada: Red Delicious, McIntosh, Cortland, Northern Spy, Ida Red, Golden Delicious, Mutsu and Empire apples. However, the researchers did not include a number of other apples popular in the United Sta...

Confocal imaging promises early detection of skin cancer

...simplest being a magnifying glass. Most techniques evaluate external skin features, such as colour or morphology. “But doctors need to look deeper into the basal layers, at least one millimetre down, to be sure of their diagnosis,?says Dr Sheblee. The original idea for using confocal microscopy to look deepe...

'EuroVacc 02' HIV Vaccine Trial Begins

... with the EuroVacc Foundation as the sponsor, will evaluate the safety of DNA-HIV-C alone and of the prime-boo...t low risk of infection. The trial will carefully evaluate the safety and immunogenicity of the combination of the vaccines, in particular their ability to gen...

FDA Approves New Treatment for Chronic Hepatitis B

...e post-marketing study of Baraclude (entecavir) to evaluate the risks of cancers and liver related complications. ...

Team Invents Device For Weighing Individual Molecules

... in physics labs, the researchers are then able to evaluate extremely subtle changes in mass of the nanodevice, and therefore, the weight of the added atoms or molecules. Roukes says that their current generation of devices is sensitive to added mass at the level of a few zeptograms, which is few billionths ...

MIT engineers an anti-cancer smart bomb

... model enables us to rationally and systematically evaluate drug combinations and loading mechanisms," says Sasisekharan. "It's not going to stop here. We want to build on this concept." ...

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