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Tag: "estrogen" at biology news

Absence of critical protein linked to infertility

...ding Protein beta. It is regulated by the hormones estrogen and progesterone. In normal conditions, the protein, driven mostly by progesterone, is expressed rapidly and in large quantities during the critical four-day implantation period in mice, Bagchi said. During this period, an embryo attaches to the wal...

Component in soy products causes reproductive problems in laboratory mice

...th." Genistein is the primary naturally occurring estrogen in plants (called phytoestrogens) and can mimic the effects of estrogen in the body. Genistein can be found in foods containing soy such as soy-based infant formulas as we...

Uncovering sex-change secrets of black sea bass

...that cause the fish to change sex. In female fish, estrogen plays the major role, he said. In males, a steroid...as the enzymes that control them. By turning off estrogen production, Berlinsky says, he can turn a female fish into a male within a week. Giving 11-ketotesto...

Protein found to control tumor growth in certain breast cancers

...epithelial cell line MCF-7 ?the cellular model for estrogen sensitive breast cancer tumors ?were used to induc...l findings one step further, researchers implanted estrogen pellets in the SCID mice to accelerate tumorigenesis. In those mice receiving Nod1 cell lines tumor...

Mayo Clinic study finds two genes predict outcome for breast cancer patients

... breast cancer affected the outcomes of women with estrogen receptor-positive breast cancer. The research team examined tissue from 206 postmenopausal women enrolled in a prospective study conducted by the North Central Cancer Treatment Group (NCCTG). They tested the level of gene expression of HOXB13 and I...

Tamoxifen for breast cancer prevention does not benefit most women

...preventing the disease. Tamoxifen is a selective estrogen receptor-modulating drug used to treat estrogen receptor-positive breast cancers. In addition, it has been shown to reduce the incidence of invasive...

High estrogen levels associated with dementia in older men

...ctive population-based study has found that higher estrogen levels in older men are associated with an increas... role. One large study showed that women receiving estrogen therapy had an increased risk of cognitive impairment and dementia. However, the evidence for how te...

New genetic test for breast cancer

... in 2006. Nearly 140,000 of these women will have estrogen receptor-positive breast cancer that has not yet spread to the lymph nodes. The standard treatment is surgery to remove the tumor, plus radiation and hormonal therapy, which cures about 80 to 85 percent of patients. Adding chemotherapy can furthe...

Ultra low-dose estrogen shown safe for post-menopausal women

...dical Center has shown that extremely low doses of estrogen had no ill effects on the cognitive abilities or g... "This is exciting. It shows that women can take estrogen safely," observes lead author Kristine Yaffe, MD, chief of geriatric psychiatry at SFVAMC and associ...

Pak1 expression increases tamoxifen resistance in breast cancer patients

A protein that activates estrogen receptors in breast cancer may play a role in resi...sed resistance to tamoxifen therapy for women with estrogen receptor positive breast cancer. Patients with ER-positive tumors and low levels of Pak1 had longer ...

New research: Soy germ isoflavones reduce bone loss

...d by about one in three postmenopausal women, with estrogen deficiency often acting as the major cause. Hormone replacement therapy has been the most effective treatment for maintaining bone density. This treatment often has adverse side effects such as an increased risk for endometrial cancer and breast ca...

Jefferson scientists identify gene mutation potentially involved in breast cancer initiation

...y 19 percent of all breast cancers that are fed by estrogen ?so called "estrogen receptor-positive" cells. The...egative showed caveolin mutations. "One-third of estrogen receptor-positive patients actually had caveolin mutations, making it one of the most common mutatio...

New path from estrogen to survival in breast cancer cells described

...to explain, in exquisite molecular detail, how the estrogen hormone can help keep breast cancer cells alive. ... research to work out the basic mechanism by which estrogen can exert a pro-life effect on cancer cells," said the study's lead author, Edward T. H. Yeh, M.D., ...

Restoring tamoxifen sensitivity in resistant breast cancer cells

...uses certain physical changes to occur between the estrogen receptor and the biological machinery that stimula...on. By coincidence, these changes also restore the estrogen receptor to a form that makes it vulnerable once again to tamoxifen," said Li Hua Wang, Ph.D., lead ...

Changing length of days reverses how estrogen affects aggressiveness in mice

...lionotus). However, in the long days of summer, estrogen decreases aggression among male Oldfield mice, a s...the southeastern United States . "We found that estrogen has totally opposite effects on behavior in these mice depending only on how much light they got eac...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...e prevention of mammary tumors in a mouse model of estrogen receptor-negative breast cancer Triterpenoids a...er potential drug, Afzoxifene, which modulates the estrogen receptor, synergize in the prevention and treatment of certain mammary tumors in mice," said Liby. "...

Novel vaccine shows promise against early-stage breast cancer

...that may help fight breast cancer, including BRCA, estrogen receptors, and HER-2/neu, all of which have been known to predict the severity of disease, recurrence and overall survival. Developing novel therapies that target these specific genetic variances may be extremely beneficial in preventing breast canc...

Molecular atlas provides new tool for understanding estrogen-fueled breast cancer

...at turn genes on and off -- operated by the cells' estrogen receptor, the master regulator of cell growth in t...nt hormone therapies, the study authors say. The estrogen receptor (ER) is an intricate protein net in the nucleus of breast cancer cells. When the receptor s...

The influence of the menstrual cycle on the female brain

What influence does the variation in estrogen level have on the activation of the female brain? ...onads (ovaries and testicles), which interact with estrogen receptors, progesterone or androgens. 7. Luteinizing hormone (LH) is a hormone produced by the p...

Molecular signature may identify cisplatin-sensitive breast tumors

...ancers contain receptor molecules for the hormones estrogen or progesterone, and in recent years antiestrogen ...5 to 20 percent of breast tumors that have neither estrogen nor progesterone receptors and also do not overexpress HER2. Since these so-called "triple-negati...

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