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Tag: "estrogen" at biology news

Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

... industrial chemical andnonsteroidal environmental estrogen used in the manufacture of foodcans, milk container linings, food storage containers and water supplypipes. About 2.5 billion pounds of the chemical are produced each year. Inparticular, the study showed that the affected class of prostate cancercel...

Bone Density Recovers After Teens Stop Injected Contraceptive

...rmones. Some contain a combination of the hormones estrogen and progestin, some contain only progestin. It is not known whether oral contraceptive use affects bone mineral density and NICHD is currently supporting a study to address this issue. The researchers measured the participants?bone mineral densities...

Controlling protein diversity

... have shown in previous studies that hormones like estrogen and progesterone can change the amounts of proteins made by their target genes. When hormone binds to receptors inside the cells, they are activated to seek out target genes. They then recruit the coactivators ?in this case CAPERá and CAPERâ. These c...

Increased risk of osteoporosis associated with gene that one in five people have

... women the variant gene speeds up the breakdown of estrogen and is associated with low density in the bones of...detoxifies foreign substances and also breaks down estrogen as a normal part of maintaining proper estrogen balance. Within the general population, several vari...

Harmful chemicals may reprogram gene response to estrogen

...e to diethylstilbestrol (DES), a synthetic form of estrogen linked to vaginal cancer, the incidence of uterine...d to estrogen, making them much more responsive to estrogen than normal," said Walker. "We realized that the DES exposure enabled estrogen to drive the tumor de...

Study reveals dramatic difference between breast cancers in US and Africa

...e. -- Second, African breast cancers often lacked estrogen receptors. Although 80 percent of breast cancers in Caucasian women have estrogen receptors, only 23 percent of African tumors did. These tumors do not depend on estrogen and thus wi...

Compounds in plastic packaging act as environmental estrogens altering breast genes

...of breast cancer entails multiple events, in which estrogen appears to play an important role," explained Russo. "Our laboratory has pioneered an in vitro system of cell transformation using estrogens and their metabolites as carcinogenic agents in human breast cells. Our data show that each compartment of th...

Tamoxifen-like drug suggests new ways to selectively block estrogen

...al drug known as GW5638 to change the shape of the estrogen receptor is helping researchers understand why dru... behave the way they do, simulating the effects of estrogen in some tissues and blocking it in others. The finding indicates that this little-known drug may pla...

By creating molecular bridge, scientists change function of a protein

...rchers gradually changed the function of the human estrogen receptor alpha, a nuclear hormone receptor mostly ...ry and urinary tract. What they did was modify the estrogen receptor in a step-wise fashion, Zhao said. They used testosterone and progesterone to build the bri...

Going To Extremes To Improve Human Health

...ceptible to fainting than men, he also studies how estrogen and progesterone influence blood pressure regulation. Minson is the winner of a 2005 American Physiology Society's Outstanding Young Investigator Award (his second since 2000) and a similar national honor conferred in 2000 by the American College of...

New Discovery May Help Doctors Treat Infertility

...e ineffective for women who lack a gene called the estrogen receptor beta. The study showed that fertility dru...s in mice that were genetically engineered to lack estrogen receptor beta. The estrogen receptor beta is one of two estrogen receptor proteins which mediate the...

Women cautioned against using herbal supplements

...phytoestrogens, could possibly block the effect of estrogen in the body and perhaps reduce breast cancer risk. However, recent clinical studies have shown that women on diets high in soy phytoestrogens experience greater cell multiplication in the breast. There is concern over this effect since it could be a ...

Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy

...phytoestrogens, could possibly block the effect of estrogen in the body and perhaps reduce breast cancer risk. However, recent clinical studies have shown that women on diets high in soy phytoestrogens experience greater cell multiplication in the breast. There is concern over this effect since it could be a ...

Scientists find a maturity gene in fly

...ich is a "nuclear hormone receptor." Hormones like estrogen and testosterone attach to these receptors, which in turn attach to genes in cell nuclei to switch the genes on or off. Nuclear hormone receptors are found in all animals, including flies and humans, and are linked to maturation. "So concluding that...

MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools

...ich is a "nuclear hormone receptor." Hormones like estrogen and testosterone attach to these receptors, which in turn attach to genes in cell nuclei to switch the genes on or off. Nuclear hormone receptors are found in all animals, including flies and humans, and are linked to maturation. "So concluding that...

Scientists discover genetic pathway responsible for breast cancer cell growth

...dvance our understanding of how the female hormone estrogen causes growth of breast cancer cells. The research...ntreal (IRCM) identifies 153 genes that respond to estrogen and one in particular that can be used to halt the growth of breast cancer cells. The study, publish...

Gene variation affects tamoxifen's benefit for breast cancer

...tamoxifen, a drug designed to block the effects of estrogen in breast tissue. The findings from this trial were derived from a large North Central Cancer Treatment Group study in which women were treated with tamoxifen, a pill that is taken daily, for a total of five years. Additional authors included the fo...

Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer

...boratory study has uncovered new details about how estrogen can activate natural pathways that kill certain br... or tumors. The results raise the possibility that estrogen therapy may overcome resistance to certain breast cancer hormonal therapies. The study appears in th...

Pain killer fights breast cancer by targeting key enzyme

...an agent that causes cells to divide, and too much estrogen can cause cells to divide too quickly. While many...e problem is that the current inhibitor drugs halt estrogen production throughout the body, said Robert Brueggemeier, a study co-author and a professor of medic...

Growth hormone is made in the brain, report scientists

... study has implications for menopausal women using estrogen replacement therapy and for athletes taking growth... males. The effect in females depended on how much estrogen they had at the time. "One interesting interpretation of these results is that exposure to a stres...

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