New vaccine prevents CMV infection and disease in mice
...ombines a DNA immunization that targets T-cells to essential genes required for CMV replication, with a killed ...esponse. The vaccine contains the DNA of two essential genes that are essential for replication of the virus. These genes – which are also found in other ...For many insects, winter survival is in the genes
...xposed to -15°C, or 5°F.) "This underscores the essential role of this gene for winter survival, suggesting that this particular heat-shock protein is a major contributor to cold tolerance in insects," Denlinger said. "It's highly likely that the other heat-shock proteins we found during diapause in the fle...Puzzling plankton yield secrets to role in evolution/global photosynthesis
... hundreds of millions of tons of carbon per day is essential for maintaining the control of the planet’s climate by counteracting greenhouse effects due to human activities. Clearly, this storage capacity is affected by changes in the photosynthetic efficiency of the algae, which in turn is linked to the envir...Master regulatory gene of epithelial stem cells identified
...f stem cells to divide. "The fact that p63 is essential for these epithelial stem cells, while other master regulators have been identified for blood stem cells and spermatocyte stem cells, suggests a fundamental requirement for tissue specificity of these regulators that we don’t understand," says McKeon...New Brandeis research sheds light on memory by erasing it
...molecule actually is. Identifying this molecule is essential to understanding memory itself as well as any disease of memory, " explained lead author John Lisman. "With this study, we have confirmed CaMKII as a memory molecule." The research involved electrically stimulating neuronal synapses to strengthen ...Scientists identify prion's infectious secret
...icial roles in biology, and prions even may act as essential elements in learning and memory. But although prions have received a great deal of scrutiny, scientists still don’t understand many of the most fundamental mechanisms of how prions form, replicate and cross from one species to another. Now, thr...Egyptians, not Greeks were true fathers of medicine
... my colleague Judith Seath, who specialises in the essential oils and resins used by the ancient Egyptians." Professor Rosalie David, Director of the KNH Centre, said: "These results are very significant and show that the ancient Egyptians were practising a credible form of pharmacy long before the Greeks. ...Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
... single-stranded overhangs nor t-loop formation is essential to prevent illegitimate repair of telomeric ends," said Dr. Bae. "Instead, a short tandem array of telomeric repeats bound by a Rap1/Trf2 complex is sufficient to impede non-homologous end joining in a highly directional manner." It has long been ...Gene thought to assist chemo may help cancer thrive
A gene thought to be essential in helping chemotherapy kill cancer cells, may act...ancer researchers to long believe that the gene is essential to successful chemotherapy. The idea is that p53 assists in killing the cancerous cells that the che...Rare cell prevents rampant brain activity
...s behind the study, believes that the mechanism is essential to understanding brain disorders like epilepsy. "A characteristic feature of epilepsy is the hyperactivation of cortical pyramid cells, which is exactly what this mechanism inhibits. It is possible that epilepsy is related to a deficit of Martinot...Lighting up life: Cold Spring Harbor Protocols presents tips for creating glowing plants
...or Protocols that span a broad spectrum of topics essential to researchers across many disciplines. ...Noise echoes in cell communications
...to not just what we hear, but a randomness that is essential to all life. "There is no life without noise; noise is the secret of life," suggests Martin, who points to the constant movement of particles under a microscope to illustrate this phenomena. Unlike a physics experiment that can produce the same r...Scientists genetically engineer tomatoes with enhanced folate content
...nly foods that pack a punch of folate, the vitamin essential for a healthy start to pregnancy. Researchers now...ould not be possible because the nutrient plays an essential role in both the production of nucleotides--the building blocks of DNA--and many other essential met...Glucose triggers brain cell death in rats after hypoglycemic coma
...mediately extrapolated to humans. Insulin is an essential hormone that moves glucose from the bloodstream to... in the hippocampus and cerebral cortex, which are essential to memory and cognition. "This study tells us for the first time that, in rats, the brain damage ...Scientists identify molecular cause for one form of deafness
... in the same way. The rigidity of these bundles is essential for hearing." Wong and his co-authors ?Illinois postdoctoral research associate Kirstin Purdy and Northwestern University professor of cell and molecular biology James R. Bartles ?report their findings in a paper accepted for publication in the jou...Discovery could lead to better control of hemorrhagic fever viruses
...ike the mouth, eyes or ears. Because of TfR1's essential function in transporting iron into cells, it is fo...t inhibits virus entry without compromising TfR1's essential function in cellular iron uptake. "If some of these antibodies work, they could be used clinica...How appetite-stimulating brain cells work overtime during fasting
... researchers said. In adults, the thyroid gland is essential to regulating metabolism. Previous studies had also established a key physiological role for the active thyroid hormone, triiodothyronine (T3), in the regulation of body temperature by heat-generating brown fat. The molecular underpinning of heat ...Mimicking how the brain recognizes street scenes
... vision. On the neuroscience end, this research is essential for designing augmented sensory prostheses, such as one that could replicate the computations carried by damaged nerves from the retina. "And once you have a good model of how the human brain works," Serre explained, "you can break it to mimic a brai...Bacterial walls come tumbling down
...rks of a great drug target," she explained. "It is essential to the survival of all bacteria. The enzymes that create the cell wall are unique to bacteria. And it is accessible; you don't have to get the antibiotics into the cell." In their structural studies, the researchers focused on Staphylococcus aureu......stidine into new proteins. Histidine residues make essential contributions to protein structure as well as the catalytic mechanisms of enzymes and must be reliably incorporated during the process of translation. Until now, bacterial, archaeal, and eukaryotic tRNAs have always been found with an extra guanyl...