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Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...in vitro biomarker to identify high-risk subjects, especially in familial breast cancer families," the authors write. "It is unclear at this time whether there are any interventions that could alter DNA repair capacity and what effect such interventions might have on risk." In an editorial, Marianne Berwick, P...

Columbia research lifts major hurdle to gene therapy for cancer

...eeliminated by surgery or radiation. Gene therapy, especially forcancer, is really starting to make a comeback."The virus's selectivity for cancer cells is based on two moleculescalled PEA-3 and AP-1 that, the researchers found, are usually abundantinside cancer cells. Both of the molecules flip a switch (calle...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...ve decreased blood flow to the muscles ofthe legs, especially during exercise, which causes pain, aching,cramping or fatigue in the muscles of their legs when they walk. Thiscondition also is called " intermittent claudication ".The Emory team, led by cardiologist Arshed A. Quyyumi, MD, andcardiology fellow Vee...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...diarrhea associated with the disease can be fatal, especially in children. One field study in Bangladesh found that E. histolytica infection occurred at least once in 80 percent of 300 children. Over a period of four years, about a third of the children suffered from amebic colitis, an ulceration of the stomach...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...out microarray-based experiments,reproductibility, especially inter-lab, is the #1 concern. Can I trustthese results? If I redo the same experiment in one month, will I beable to compare both? The NIH recently demonstrated that microarrays experiments performed in different labs "have a high degree of repro...

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

...rable individuals. They encourage physicians to be especially thorough when performing medical exams, and in taking patient histories to be alert for signs of heart rhythm disturbances. Implications of the Findings "In no way does it mean patients shouldn't receive protease inhibitors," says Andrew Badley, M....

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

...th care costs.Scientist have known since 1934 that especially harmful strains ofEnterococcus produce a toxin that destroys other cells, including humancells and even other types of bacteria. They also knew that this toxinwas made only under some conditions. Until Gilmore’s study, scientistswere unable to explai...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

... trying to figure out what those speed limits are, especially with regard to varying amounts of clathrin," Dr. Ryan explained. However, they faced one methodological roadblock. As Dr. Ryan explained, scientists have long known how to gauge the importance of particular proteins, using a kind of Òon/offÓ compar...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...ing right now to get a company interested in this, especially because the mice used in our trial seemed to experience minimal toxicity -- a good sign that patients might tolerate these compounds, too," Dr. Huang said. "It's all very exciting," he said. "Metastatic disease is such a tough problem, and these com...

Elephants imitate truck noises, other animals

... behavior and acoustics signals of marine mammals, especially dolphins and whales, for decades. "It is exciting to see that African savannah elephants follow a pattern we've seen in other terrestrial and aquatic species capable of vocal learning, "Tyack said. "Vocal learning should also occur in other species ...

Elephants imitate sounds as a form of social communication

... behavior and acoustics signals of marine mammals, especially dolphins and whales, for decades. "It is exciting to see that African savannah elephants follow a pattern we've seen in other terrestrial and aquatic species capable of vocal learning, "Tyack said. "Vocal learning should also occur in other species ...

Nano-Probes Allow an Inside Look at Cell Nuclei

... through these tiny slits, Chen and Gerion used an especially compact cadmium selenide/zinc sulfide quantum dot coated with silica. Next, they stole a trick from a virus's playbook to smuggle this nanocrystal past the highly selective membrane that guards the entrance into the nucleus. In nature, a virus called...

Study Models Impact Of Anthrax Vaccine

... ideal, and a new improvedanthrax vaccine could be especially helpful in reducing duration ofantibiotic treatments.?...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...use "it measures changes in the cell architecture, especially those arising from alterations in protein density, cytoskeleton shape, and distribution of mitochondria - changes that occur when a cell becomes cancerous," says Gourley. "One would think that if a cell became nonfunctional, it would become disorgan...

Simple drug has the potential to save many lives threatened by malaria

...The majority of fatalities occur outside hospital, especially in rural areas. For those who do make it to hospital, half of deaths occur within 24 hours of admission. Conventional treatment, given by injection, is not possible to administer outside hospital, so buying time by starting treatment which is easy t...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...TEL2 should be considered a new diagnostic marker, especially in patients who don't have the classic genetic mutations that physicians normally use to diagnose the disease. It will also be very interesting to study the effect of drugs that block TEL2 activity, since such an approach might one day represent an e...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...ectivity of nervous system synapses early in life, especially the first week after birth in rats, they may be involved in the ability to learn and remember, possibly via some link (says Bilbo) to cytokine IL-1BETA production. ...

Asthma gene clusters identified

...tain tissue in sufficient quantities for analysis, especially during an asthma attack. But because asthma begins in childhood, the genes identified in adults may not reflect genes involved in childhood asthma, she said. This study exclusively focused on genes associated with epithelial cells. Genes associated ...

US life expectancy about to decline, researchers say

...n, which is based on the dramatic rise in obesity, especially among young people and minorities, is from a speci...reased funding for obesity research and treatment, especially in children. They also point out that new investment into the Social Security system, while at the s...

Cricket's finicky mating behavior boosts biodiversity

...ributing to an "explosion" of new cricket species, especially on Hawaii, the largest and youngest island in the Hawaiian archipelago, say the two scientists. Some 38 different species of the cricket now inhabit the island chain. Among all animals, say Mendelson and Shaw, only the African cichlid fish spawns ne...

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