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Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

Dana-Farber Cancer Institute researchers have identified a molecular mechanism in the liver that explains, for the first time, how consuming foods rich in saturated fats and trans-fatty acids causes elevated blood levels of cholesterol and triglycerides and increases one's risk of heart disease and certain cancers. .. . Until now, scientists lacked a detailed exp...

Spleen may be source of versatile stem cells

A year ago, Massachusetts General Hospital (MGH) researchers discovered that the spleen might be a source of adult stem cells that could regenerate the insulin-producing islets of the.pancreas. In a follow-up to that unexpected finding, members of the.same team now report that these potential adult stem cells produce a.protein previously believed to be present only during the embryonic.developmen...

UCSB scientists probe sea floor venting to gain understanding of early life on Earth

New keys to understanding the evolution of life on Earth may be found in the microbes and minerals vented from below the ocean floor, say scientists at the University of California, Santa Barbara. .. . "There is a great deal of interest in the microbes of the E...

Researchers discover way to make cells in the eye sensitive to light

Researchers have discovered a way to make.light sensitive cells in the eye by switching on a single gene..According to research published online today in Nature, the team from.Imperial College London and the University of Manchester, have.discovered that activating the melanopsin gene in the nerve cells.causes them to become light responsive, or photoreceptive. . Using.mouse cells, the researcher...

Source of molecular triggers in cutaneous T cell lymphoma identified

In a study published in the journal Blood, Yale scientists identify the molecular triggers that stimulate Cutaneous T Cell Lymphoma (CTCL) cells to clonally expand into large populations of malignant lymphocytes. .. CTCL is the most common adult malignancy of T lymphocytes, the white blood cells of the immune system. Finding CTCL triggering factors has been a major goal of Richard L. Edelson, M.D...

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

Made-to-measure skin and bones, which could.be used to treat burn victims or patients who have suffered severe.disfigurements, may soon be a reality using inkjets which can print.human cells..Scientists at The University of Manchester have developed the.breakthrough technology which will allow tailor-made tissues and bones.to be grown, simply by inputting their dimensions into a computer. . Profe...

Lack of enzyme turns fat cells into fat burners

Lack of the enzyme, acetyl CoA carboxylase 2.or ACC2, appears to turn the adipose or fat cells of mice into fat.burners, explaining in part why the animals can eat more and weigh less.than their normal counterparts, said Baylor College of Medicine.researchers..The report that appears online today in the Proceedings of the National.Academy of Sciences. . "We.studied the fat cells in these mice bre...

Controversial drug shown to act on brain protein to cut alcohol use

Medication.against nicotine addiction is nowadays readily available. However, a.similar and equally dangerous addiction, alcoholism, can't yet be.controlled by drugs. Or can it be? Researchers from the University of.California in San Diego identified a natural compound able to block.alcohol addiction in rodents. We can only hope that anti-alcoholism.patchs or gum will be available in a close fut...

Researchers find how protein allows insects to detect and respond to pheromones

University of Washington TechTransfer.recently licensed software that will give scientists a huge advantage.in the fight against disease..The software, known as Rosetta, predicts how proteins fold, information.that is highly valuable to biological and biomedical researchers..UW Tech Transfer's Digital Ventures licensed Rosetta software without.charge to the Institute for Systems Biology (ISB), a...

Researchers Uncover Key Step In Manufacture of Memory Protein

A cellular enzyme appears to play a crucial role in the manufacture of a protein needed for long-term memory, according to a team of researchers led by scientists at the National Institute of Child Health and Human Development of the National Institutes of Health. .. . “Understanding how BDNF is made may help us to...

Computers to be used to find blueprint for new influenza drug

Researchers at the University of Bath have won a £261,000 grant to use the latest software to produce a blueprint of a designer drug that could stop influenza and some other diseases from replicating in humans. .. .. Professor Ian Williams, of the Department of Chemistry, will begin work in April on a project that could help pharmaceutical companies develop a better drug that could be taken by pe...

Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates

The replenishment of missing neurons in the.brain as a treatment for Parkinson disease reached the stage of human.trials over 15 years ago, however the field is still in its infancy..Researchers from Kyoto University have now shown that.dopamine-producing neurons (DA neurons) generated from monkey embryonic.stem cells and transplanted into areas of the brain where these neurons.have degenerated i...

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

Late update.tonight; my girlfriend is sick and I took care of her. First headline :.a newly discovered virus causing respiratory infection. Let's hope its.just a coincidence :) .A newly discovered virus may be responsible for many respiratory tract.illnesses in infants and children, and may be associated with an.important multi-organ disease whose cause has remained a mystery for.decades, accord...

Learning to fight an adversary that won't stay down

New biomolecular technologies have largely failed to deliver the hoped-for knockout punch breakthrough against the defences of disease-causing bacteria, says a leading Canadian specialist in antibiotic resistance. .. Techniques such as genomic sequencing and high throughput screening were expected to make the development of new antibiotic compounds easier and more productive. But in most cases th...

Improved Outcomes Releases GeneLinker(TM) Gold and Platinum Version 4.6

Improved Outcomes Software (IOS) today.announced the release of GeneLinker(TM) Gold and Platinum 4.6, new.versions of the award-winning Gene Expression and Proteomics Analysis.Software products.."The new releases are focused primarily on importing and analyzing.protein biomarker data, a high priority for many of our customers. For.example, we have integrated the Protein Biomarker Package into the...

Scientists seek answers on what activates deadly anthrax spores

Scientists at Wake Forest University Baptist Medical Center and three other institutions are setting out to find what activates the spores in anthrax, the deadly bacterial infection that is back in the news. . .. Clai...

NYU researchers simulate molecular biological clock

For many years, DNA and proteins have been.viewed as the real movers and shakers in genomic studies, with RNA seen.as little more than a messenger that shuttles information between the.two. But researchers from Whitehead Institute for Biomedical Research.and Massachusetts Institute of Technology have discovered that small.RNA molecules called microRNAs regulate thousands of human genes--more.than...

Dinosaur DNA? New Patent Covers Degraded DNA recovery

The US Patent Office issued Patent # 6,872,552, "A Method of Reconstituting Nucleic Acid Molecules" today to Burt D. Ensley, Ph.D, Chairman of MatrixDesign, and CEO of DermaPlus, Inc. The patent covers methods for recovering and reconstituting genes from "degraded" DNA samples, and could allow scientists to reassemble everything from prehistoric, extinct animals to unsolved crime scenes. . "This...

Researchers reveal the infectious impact of salmon farms on wild salmon

A new study published in the March 30th edition of the prestigious scientific journal Proceedings of the Royal Society B (a publication of the UK's national academy of science) shows that the transfer of parasitic sea lice from salmon farms to wild salmon populations is much larger and more extensive than previously believed. . This quantitative analysis of parasite transfer is a scientific miles...

Jefferson Virologists Coax HIV Out of Hiding

When researchers came up with the powerful.cocktail of anti-HIV drugs known as highly active antiretroviral.therapy (HAART), they hoped they had found a way to finally rid the.body of the virus. But they were wrong. The virus instead goes into.hiding, dormant and practically undetectable in the body ?and.impervious to attack. While HAART manages to keep the virus at bay,.it’s still quite capable...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

A scientist at the Marine Biological.Laboratory (MBL) has published the results of an EPA-funded clam embryo.study that supports her hypothesis that, when combined, the pollutants.bromoform, chloroform, and tetrachloroethylene--a chemical cocktail.known as BCE--can act synergistically to alter a key regulator in nerve.cell development. While scientists have previously studied the effects.of these...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

Gene therapy methods that specifically target muscle may reverse the symptoms of a rare form of muscular dystrophy, according to new research in mice conducted by medical geneticists at Duke University Medical Center. Infants born with the inherited muscular disorder called Pompe disease usually die before they reach the age of two. The researchers also said their approach of targeting corrective...

In the sea slug's defense against lobsters, confusion is key

Like many other marine creatures, Aplysia, a common sea slug, enlists chemical defenses against its predators, but the mechanisms by which such chemical attacks actually work against their intended targets are not well understood by researchers. New work has now shown that such chemical defenses can involve modes of trickery that had not previously been appreciated as components of chemical defen...

Researchers identify target for cancer drugs

For nearly a decade, scientists have been trying to fully understand a particular communication pathway inside of cells that contributes to many malignant brain and prostate cancers. While scientists have identified elements of this pathway, other key components have remained a mystery. Researchers at Whitehead Institute now have discovered a missing puzzle piece, a finding that may present drug...

Plant hemoglobins: Oxygen handlers critical for nitrogen fixation

Hemoglobins, key components of our blood, are ancient proteins with well-known roles in oxygen transport and respiration in animals. Hemoglobins are also present in plants and bacteria, but until now the physiological role of plant hemoglobins has been unclear. A group of researchers reveal this week that one such mysterious plant hemoglobin serves to assist in the fixation of nitrogen in the roo...

Vital step in cellular migration described by UCSD medical researchers

A vital molecular step in cell migration, the movement of cells within the body during growth, tissue repair and the body's immune response to invading pathogens, has been demonstrated by researchers in the University of California, San Diego (UCSD) School of Medicine. Published in the March 27 online edition of Nature Cell Biology and the journal's upcoming April print edition, the study describ...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

Two compounds that zero in on cancer cells spreading throughout the body, while ignoring primary tumor cells, could someday give doctors a whole new weapon in the fight against tough-to-treat metastatic disease, according to Weill Medical College of Cornell University researchers. . .. "They're unbelievably effective, and in vitro study suggests they'll work just as well at inhibiting the migrati...

ASU researchers finds novel chemistry at work to provide parrot's vibrant red colors

Parrots, long a favorite pet animal, are attractive to owners because of their vibrant colors. But those colors may mean more to parrots than what meets the eye. .. . The work casts a new light on what is chemically...

UCSD researchers maintain stem cells without contaminated animal feeder layers

The growth and maintenance of human embryonic stem cells in the absence of contaminated animal products has been demonstrated by University of California, San Diego (UCSD) School of Medicine researchers in the Whittier Institute, La Jolla, California. . Published in the April 2005 issue of the journal Stem Cells, the study shows that laboratory culture media enriched by a human protein called act...

Researchers discover molecule that causes secondary stroke

Scientists at the University of Cincinnati (UC) College of Medicine have discovered the cause of a deadly type of secondary stroke known as cerebral vasospasm. . .. Vasospasm, says neurology department researcher Joseph Clark, PhD, results from a buildup of toxins caused by bleeding from the initial stroke. "Norma...

Researchers find missing genes of ancient organism

Yale scientists report in the journal Nature that the "missing" genes for tRNA in an ancient parasite are made up by splicing together sequences in distant parts of the DNA genome. .. .. Surprisingly, Söll's...

Papers of DNA Pioneer and Nobel Laureate Francis Crick Added to National Library of Medicine’s Profiles in Science Web Site

The National Library of Medicine, a part of the National Institutes of Health, is proud to present an extensive selection from the papers of one of the twentieth century’s greatest scientists, Francis Crick, on its Profiles in Science Web site. . .Don't miss Crick's .. This latest collection on Profiles in Science represents a close collaboration between the National Library of Medicine and the...

Researchers trace evolution to relatively simple genetic changes

In a stunning example of evolution at work, scientists have now found that changes in a single gene can produce major changes in the skeletal armor of fish living in the wild. .. . "Our motivation is to try to understand how new animal types evolve in nature," said molecular geneticist David M. Kingsley, a Howard Hughes Medical Institute investigator at the Stanford University School of Medicine....

Researchers add new tool to tumor-treatment arsenal

A new study demonstrates the potential effectiveness of treating tumors by combining agents that damage DNA with a drug that sensitizes cancer cells to these agents. . .. Dr. Thomas and a co-author Stefano Fumagalli, PhD, began this research while working at the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland, and complete...

Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers

A new study investigating the respiratory system of insects may have solved a mystery that has intrigued physiologists for decades: why insects routinely stop breathing for minutes at a time. .. .. Timothy Bradley, professor of ecology and evolutionary biology at UCI, and Stefan Hetz,...

New protein discovered by Hebrew University researchers

Researchers at the Hebrew University of.Jerusalem have succeeded in discovering and isolating a new protein.from the poplar tree with special structural and qualitative.characteristics that could have consequences for development of future.nanocapsules for drug delivery to cancer cells..In addition to being obtained from plant tissue, the protein can now.also be produced in large quantities as a...

Zebrafish may hold key to understanding human nerve cell development

Glia appear essential for 'hair cells'.responsible for hearing and balance. Traditionally viewed as supporting.actors, cells known as glia may be essential for the normal development.of nerve cells responsible for hearing and balance, according to new.University of Utah research. The study is reported in the January 6,.2005 issue of Neuron and is co-authored by scientists at the University.of Was...

First real-time view of developing neurons reveals surprises, say Stanford researchers

Scientists have believed that neurons need a long period of fine-tuning and training with other neurons before they take on their adult role. But after using new technology for the first time to watch these cells develop, a team of researchers at the Stanford University School of Medicine found that neurons come into this world with a good idea about what they'll become as adults. . The work, whi...

New insight into people who 'see' colors in letters and numbers

People with a form of synesthesia in which they see colors when viewing letters and numbers really do see colors, researchers, led by Edward M. Hubbard of the University of California San Diego, have found. What's more, functional magnetic resonance imaging (fMRI) of their brains reveals that they show activation of color-perception areas. . The researchers said their findings lend support to the...

FDA Warns Consumers Not to Use Home-Use Diagnostic Kits Marketed by Globus Media

The Food and Drug Administration (FDA) is warning consumers not to use unapproved home-use diagnostic test kits that have been marketed nationwide via the Internet by Globus Media, Montreal, Canada. The use of these products could result in false results that could lead to significant adverse health consequences. The illegal kits are labeled as: Rapid HIV Test Kit. .. . * One Step Cassette Sty...
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Breaking Biology News(10 mins):Trisomy 21: How an extra little chromosome throws the entire genome off balance 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 3Patented research remotely detects nitrogen-rich explosives 2Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3
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Breaking Medicine News(10 mins):Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:CU researchers discover target for treating dengue fever 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Internet use can help ward off depression among elderly 2
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