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Tag: "errors" at biology news

Study suggests that publicly available genome data may contain small but significant errors

..., and many researchers may be unaware of potential errors lurking within the publicly available published, o... validating sequence assembly and indicating where errors need correction. Comparing data from their inferred probe maps to the available sequence assemb...

Cholesterol gets 'thumbs up' for role in digit development

...st of suspects. In addition to limb deformities, errors in Sonic hedgehog signaling are involved in a number of other human conditions including cancer and a condition known as holoprosencephaly, a congenital malformation of the forebrain. Chiang is currently examining the role of cholesterol-modified S...

Common enzyme is a key player in DNA repair

...nome in dividing cells. In humans, uncorrected DNA errors passed along to the new daughter cells can lead to cancer. When DNA integrity is at stake, a family of proteins known as translesion DNA polymerases comes to the rescue. They cannot actually repair a damaged strand of DNA, but they can smooth over t...

Oops! Researchers publish new findings on the brain's response to costly mistakes

...characterized by an untoward anxiety or fear about errors or failures in certain aspects of everyday life, w...hat responded in our OCD study on regular, no-cost errors also responded in healthy individuals when we made the error count more." The new research confirms...

Relationship of brain and skull more than just packaging

...often use were highly variable and had the biggest errors in reproducibility," says Richtsmeier. "We eventually chose brain locations that were easier to identify reliably such as the most posterior point or the centroid of small neural structures." The researchers did not compare one brain to another or o...

Nanopore method could revolutionize genome sequencing

...ethod we propose has the potential of having fewer errors than the present method, which is based on the Sanger method," said Johan Lagerqvist, a graduate student in physics at UCSD and the lead author on the paper. "It should be possible to sequence strands of DNA that are tens of thousands of base pairs ...

Computer scientist sorts out confusable drug names

...ps to reduce even just 10 per cent of prescription errors in the U.S. that translates into helping a lot of people, and it's very satisfying to contribute to that." ...

UF scientists test improved gene therapy method for hereditary heart conditions

...Pompe disease early next year. "Many of the inborn errors have their most feared effects early in life, so we're pushing toward being able to do prevent disease as opposed to trying to correct later. We keep trying to get closer and closer to clinical studies that will help patients-that's the real goal." ...

MIT sheds light on how tumor cells form

...he defective cells, which tend to have very subtle errors in them. (These subtle errors are believed to be the cause of aneuploidy and the rapid growth of tumors.) Before cells divide, in...

How IVF could be causing genetic errors in embryos

...ng in vitro fertilisation could be causing genetic errors that are associated with certain developmental syndromes and other abnormalities in growth and development, such as low birth weight. Researchers told the 22nd annual conference of the European Society of Human Reproduction and Embryology today (Mon...

'Signature' of chromosome instability predicts cancer outcomes

...t risk for mutations due to environmental insults, errors in gene replication, and other factors that can cause chromosomes to break and bits of DNA to be lost, duplicated or reshuffled to the wrong chromosomes. Cells have repair mechanisms that constantly fix this damage, but when the repair process breaks...

'Sticky' mice lead to discovery of new cause of neurodegenerative disease

...ggers cell death. But this new mechanism points to errors in executing the genetic instructions, which are distinct from known causes of neurodegenerative diseases, such as Alzheimer's and Huntington's diseases. HHMI investigator Susan L. Ackerman and her colleagues reported their findings in an August 1...

Light guides flight of migratory birds

...ky polarized light patterns. To avoid navigational errors as cue availability changes with time of day and weather conditions, these "compass" systems must be calibrated to a common reference. Experiments over the last 30 years have failed to resolve the fundamental question of how migratory birds integrate...

Speeding the search for elusive chromosomal errors

... For many of these rare disorders caused by small errors in chromosomes, improved diagnosis does not mean that physicians can provide more effective treatments, at least not immediately. In the long run, adds Dr. Shaikh, better knowledge of the underlying genetic cause of a disease may provide targets for ...

AIDS study challenges conventional treatment guidelines for HIV patients

...he investigators considered the possible effect of errors in the measurement of the CD4 cell count and the HIV viral load. These results represent a shift in the paradigm that the rate of CD4 cell loss in a given HIV-infected individual can be accurately predicted by his or her viral load. Predicting dis...

Two central mysteries in genome inheritance solved at UCSD

...said Desai. Cells avoid such a fate by detecting errors in attachment to the spindle, breaking down these defective attachments and starting over. But until now, scientists did not understand how cells detected such an error. Sharsti Sandall, a graduate student in the Biomedical Sciences Program at UC...

Mayo discovers protein as potential tactic to prevent tumors

...to the next. The Mayo researchers showed that when errors in genes are irreparable, CDK2 modifies another ce...nt genetic codes that can lead to disease. Genetic errors that sneak past the cell's quality control check-points can make the cell prone to develop into canc...

Sequencing of the oyster mushroom genome

...d text that demands an assurance that there are no errors in what has been read. To understand what this really involves, Pisabarro gives us an example: 70 million letters would be equivalent to a volume of more than 11,500 pages of text. If the pages are normal, folio size and are placed side by side, t...

Novel experiment documents evolution of genome in near-real time

...ts presumably as the result of naturally occurring errors in copying DNA into daughter cells during cell division. The precise changes in the sequence of DNA subunits were determined with comparative genomic sequencing technology from NimbleGen Systems, and further analyzed with technology from Sequenom Inc...

Protein averts cell suicide but might contribute to cancer

...t this protein, an enzyme called Dpo4, often makes errors when copying the genomic DNA sequence that later might cause the cell to become cancerous. The findings by researchers with Ohio State University 's Comprehensive Cancer Center are described in two back-to-back papers in The Journal of Biological...

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