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Tag: "errors" at biology news

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...t source of variation inthese studies. Measurement errors common to all labs were the next mostcommon contributor, and biological differences in different sampleswere the largest source of variation.“This study indicates that microarrays have a high degree ofreproducibility, as long as standardized protocol...

Whole genome fine map of rice completed

...d in the two genomes. After adjusting for residual errors of predictions with EST data, the number of genes is estimated to be between 30,000 to 40,000. Among them, only 2-3% genes are unique to any one of the two strains. Even though the genetic difference between the two strains is small, there are large...

How the environment could be damaging men's reproductive health

...of male reproductive disorders, possibly caused by errors in development of the foetal testes. The Lithuanian study investigated 1,204 boys born in one hospital in Lithuania between October 1996 and November 1997. The boys were examined at birth and one year later. Sixty-nine (5.7%) of the boys had one or ...

Unchecked DNA replication drives earliest steps toward cancer

...e of the genes, cancer is always rooted in genetic errors or problems in gene regulation. Scientists have id...NA replication stress. This stress leads to random errors in the DNA duplication process ?breaks in the DNA that disrupt genes, for example. Unless halted, th...

Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans

...ff some of the population, but also caused genetic errors in survivors. Those errors would have later eliminated more of the population." The virus had invaded the genome in the germli...

High fidelity keeps human DNA assembly line humming

...ted out." In addition to better understanding how errors are prevented, Burton's research team also learned ways errors are corrected during rapid RNA synthesis. To learn about error correction, Burton's team stalled the...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

...NSCLC constitute only a portion of all the genetic errors that drive the disease. Our work provides a good starting point for scientists looking for others." As part of the study, investigators did microarray analyses on the two major subtypes of NSCLC, adenocarcinoma and squamous cell carcinoma, and found...

Can't serve an ace? Could be muscle fatigue

... brain must activate them harder and this leads to errors about where the different body parts are located." Professor Proske said the research could also offer insight into the symptoms of some motor system diseases such as Parkinson's disease. The abnormal movements were likely to relate, in part, to a d...

Carnegie Mellon University research reveals how cells process large genes

...r machinery eliminates long introns without making errors has puzzled scientists for years. Now, investigators at Carnegie Mellon University have discovered that a novel mechanism, called recursive splicing, removes long introns by steadily paring them down in a predictable fashion and joining the remaini...

Reversal of role for a viral protein associated with the development of lymphoma

...r machinery eliminates long introns without making errors has puzzled scientists for years. Now, investigators at Carnegie Mellon University have discovered that a novel mechanism, called recursive splicing, removes long introns by steadily paring them down in a predictable fashion and joining the remaini...

Stressed cells spark DNA repair missteps and speed evolution

... process goes wrong, the repair process introduces errors into the DNA. When graduate student Rebecca G. P...ol where the break in DNA occurred, she found that errors occurred right next to the break in the stressed cells, and that the rate of errors was 6,000 fold h...

Life's origins were easier than was thought

... they would not be able to correct the replication errors (mutations). Therefore they were unable to contain...he error threshold, that is, the maximum number of errors that may occur during the replication process of ribozymes without this affecting its functioning, i...

Study provides insight into cellular defenses against genetic mutation

...s all new mRNAs for errors, and initiates NMD when errors are detected. A second "steady-state" round translation then directs the mass production of normal proteins based on "NMD-approved" mRNAs. Recently, Maquat's team has worked to identify the roles of proteins involved in NMD, the focus of the Nature ...

Cracking the perception code

...e neural activity perfectly explained the monkeys' errors when judging different durations of stimuli. Romo suggested that the best explanation for the behavioral data was to assume that the monkeys pay the most attention to the first 250 milliseconds of neural firing, and that their attention falls off ex...

War on terror meets war on cancer

..."As with any scientific measurement, there will be errors associated with this calculated metabolic rate," Hegg says. "Thus, having a second way to measure metabolism would be beneficial." A potential second method could measure oxygen and perhaps hydrogen isotope ratios in a common metabolite ?a product...

Double trouble: Cells with duplicate genomes can trigger tumors

...called "double-value" cells are produced by random errors in cell division that occur with unknown frequency. The generation of these genetically unstable cells appears to be a "pathway for generating a tumor," says David Pellman, MD, a pediatric oncologist at Dana-Farber and at Children's Hospital Boston. ...

Genetic testing still smart choice, despite uncertainties

...r is not due to a technical mistake but to natural errors occurring during early cell division in the embryo." Extracting test cells before the embryo divides a third time could reduce the number of misdiagnoses because of mosaicism, the UF researchers suggest. Improving culture conditions could help too, ...

Is it Possible to Change Prescribing Habits?

... for hospitals to tackle the problem of medication errors is to install computerized monitoring systems, which can reduce ADEs by 28%?5%. Apart from the obvious benefits to patients, these systems can save hospitals as much as $500,000 annually in direct costs. However, despite the potential, fewer than 10%...

Discovering the first steps in transcription-coupled repair

...t transcription. In these cases, the likelihood of errors in the transcribed RNA and eventually in the resulting protein is increased. What Cooper and her colleagues found, however, was a different, unexpected path. It appears that instead of being removed, the stalled RNAPII can be left in place and remod...

Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool

A standard Internet protocol that checks errors made during email transmissions has now inspired a revolutionary method to transform DNA microarray analysis, a common technology used to understand gene activation. The new method, which blends experiment and computation, strengthens DNA microarray ...

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