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Tag: "epithelial" at biology news

BRCA1 causes ovarian cancer through indirect, biochemical route

...e tumor cells were analyzed, they were found to be epithelial cells very similar to those found in human ovarian...normally give off a chemical signal that stops the epithelial cells from growing out of control. When that chemical signal disappears or is muted by a mutation in...

U-M scientists find genes that control growth of common skin cancer

...ould be reprogrammed to differentiate into various epithelial celltypes, ultimately capable of assembling fully-formed hair follicles.These results suggest that BCCs contain cells capable of multi-lineagedifferentiation, similar to normal hair follicle stem cells from whichthey may arise.If the results of this ...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

... tumorigenesis, in that genetic events outside the epithelial layer itself have a profound effect on tumor initiation. Thus it appears likely that this study will foster additional research into other mesenchymal genetic modifiers, and into potential therapeutic approaches that affect the signaling between the ...

The Bacteria's guide to survival

...mbranes. The study examined gene activity in human epithelial cells infected with Neisseria gonorrhoeae, the bacteria responsible for the sexually transmitted disease gonorrhea. By comparing cells infected with normal N. gonorrhoeae to those infected with a mutant strain with defective pili, the researchers fo...

Asthma gene clusters identified

...study exclusively focused on genes associated with epithelial cells. Genes associated with mucosa and underlying cells are likely to be involved as well. Dr. Hershey is expanding her research in cooperation with the Computational Medicine Center (CMC), a research partnership with Cincinnati Children's and the ...

Hirsute Or Hairless? Two Proteins May Spell The Difference

...s, transgenic mice, and cell cultures—to study how epithelial buds, the precursors of hair follicles, form. Thei...ud formation by first directing a small cluster of epithelial cells to form a placode, the pouch that forms hair plugs. The placode in turn directs underlying mes...

A little stress gives beneficial oomph! to immune system

... challenges or wounds involve on the skin or other epithelial linings of the body," Dhabhar said. "If nothing happens immunologically following stress ?the skin isn't cut or wounded in some other way ?activated leukocytes usually return to their resting position in a few hours." Some of the mice in the study w...

Disease progression model of pancreatic cancer developed by Penn researchers

...d cells. Genomic instability is seen in many human epithelial cancers, including pancreatic cancer, and is thoug...useful to understanding human pancreatic and other epithelial cancers because the key event of genomic instability that has been very difficult to model in the mo...

Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

...s). Gamma-delta T cells migrate from the thymus to epithelial tissues such as skin and the linings of the lung. While their precise role remains poorly understood, they perform vital protective functions. Certain lung infections easily cleared from normal laboratory mice are a death sentence for those lacking g...

B cells are required for development of epithelial cancer associated with chronic inflammation

...l B cell activation is an essential step for early epithelial neoplastic development, and B cell-derived soluble mediators are necessary for establishing chronic inflammatory states that potentiate cancer development," explains Dr. Coussens. "Pharmacological interventions attenuating B cell activation or blocki...

U of T researchers map role of Epstein-Barr virus in cancer

...ell cancers like Burkitt's lymphoma as well as the epithelial cell cancer, nasopharyngeal carcinoma. EBNA1 is a protein coded in the Epstein-Barr virus and suspected to play a role in the development of cancer," says Lori Frappier, professor in medical genetics and microbiology at U of T and senior author of a ...

Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs

...ransferrin can bind to receptors on the intestinal epithelial cells and be transported across the GI tract to the blood stream," Shen says. "Humans naturally produce transferrin to move iron through the blood to the liver, spleen and bone marrow. It has been used to carry some protein-based drugs in a piggy-bac...

Study: Harmless virus kills some cancers

.... In this study, the team first used HPV infected epithelial cells and normal human epithelial cells, which are natural hosts for both AAV2 and HPV. In cultures infected with both AAV2 and HPV, t...

Mass production of human papillomavirus could lead to gains against cervical cancer

...e cycle, the virus lurks in undifferentiated basal epithelial (skin) cells, said Ahlquist. Once there, it remain...s visibility to the immune system. Only after the epithelial cells begin differentiating does the virus emerge as distinct, infective viral particles, called vir...

Can two killers make a cure?

...g genes to cells' genomes, it does not target lung epithelial cells. Ebola binds strongly to these cells, so Gary Kobinger at the University of Pennsylvania in Philadelphia tried adding a surface protein from Ebola to HIV. Initial tests on mice showed the hybrid virus was very efficient: the gene it carried was...

Gene loss accelerates aging

...ar tissues--including skin and other multi-layered epithelial tissues--after the animals reached maturity. The effects of premature aging observed in these p63 deficient mice (image available on request) were hair loss, reduced fitness and body weight, progressive curvature of the spine, and a shortened lifesp...

New study finds how cells with damaged DNA alert the immune system

...nt role." The researchers put cultures of ovarian epithelial cells and fibroblasts from mice through a battery of abuse, including heat shock, pH changes, oxygen deprivation and starvation. However, the only type of stress that set off the sequence of events associated with impairment of a cell's genetic mater...

Renewed hope for Parkinson's patients

...nt role." The researchers put cultures of ovarian epithelial cells and fibroblasts from mice through a battery of abuse, including heat shock, pH changes, oxygen deprivation and starvation. However, the only type of stress that set off the sequence of events associated with impairment of a cell's genetic mater...

Discarded placentas deliver researchers promising cells similar to embryonic stem cells

...results of their studies, these so-called amniotic epithelial cells could in fact be directed to form liver, pan...ers calculate there are about 300 million amniotic epithelial cells that potentially could be expanded to between 10 and 60 billion cells relatively easily. "Pro...

FSU biologists describe key role of signal-transcribing gene during cell cycle

...rough the "Notch" gene, which regulates a layer of epithelial cells as they replicate and divide. But when Cut garbles those signals the result is uncontrolled cell proliferation, sometimes with dire genetic and health consequences. Results of the study are described in the Oct. 1 edition of the journal Develo...

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