Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
...reds of genes," Bernstein notes. He and Schreiber enlisted the help of Affymetrix, which makes so-called "gene chips" that rapidly scan millions of small sections of chromosomes to detect gene activity. But the scanning results left them with a huge amount of data, and the daunting task of deciphering what i......unting for a third of the hypothetical genes. They enlisted analytic software to scour public databases and applied expression data to improve gene annotation, identifying similarities to known proteins for 97 percent of these hypothetical proteins. All told, computational and experimental evidence provided f...Breast tumors in mice eradicated using cancer vaccine
...they expand and activate helper T cells, which are enlisted into the immune response. But Listeria has evolved to escape from this vacuole and survive inside the cytosol of antigen-presenting cells, where it can replicate and grow, unlike other bacteria. So, although some of the bacteria are destroyed in th...Infant transplant patients resist infections that kill adult AIDS patients
...ant patients' immune systems can be identified and enlisted to fight viruses without T cells, it perhaps could be therapeutically manipulated in adult patients to arrive at new and better treatments for various diseases involving immune system deficiencies. "We were struck by the fact that when a heart trans...Researchers test new way to quit smoking
...he University of Otago will work with 1100 people, enlisted through the national Quitline. Half the participants will be offered nicotine patches or gum two weeks before they attempt to quit; the other half will begin using the patches or gum on the day that they quit. "Using nicotine gum or patches while st...Cardiologist's 'living chip' changes science of disease monitoring
..., immediately saw the promise in Rosero's idea and enlisted the assistance of High Tech Rochester. "This type of product is referred to as a 'disruptive technology,'" said John Fahner-Vihtelic, deputy director of the Office of Technology Transfer. "It has the potential to change the way things currently ar...Turning a cellular sentinel into a cancer killer
...ow exploring how the innate immune system might be enlisted against cancer. Jacks's team used a different technique to reactivate p53 in lymphomas and sarcomas. In their experiments, the researchers produced mice whose cells did not have p53 activity. These mice were genetically engineered so that the drug ...... images. Different senses and motor responses were enlisted in order to ensure that any interference between the two tasks was not specific to a particular sensory or motor modality, but instead originated at a central information-processing bottleneck. The results revealed that the central bottleneck was ...