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Tag: "engineered" at biology news

Sickle cell disease corrected in human models using stem cell-based gene therapy

...ckle shaped hemoglobin S. The therapeutic gene was engineered into a lentiviral vector and introduced into hematopoietic stem cells. After the cells received the treatment, they made normal hemoglobin. "This proved our hypothesis that you can simultaneously add one function and delete another in the same cel...

A little telomerase isn't enough

...ly. Now, the Hopkins researchers report that mice engineered to have just half the normal amount of telomerase can't maintain their stem cells' chromosome ends, showing that a little telomerase isn't enough. In these "half-telomerase" mice, their telomeres shortened over time, bringing an early demise to stem ...

Student scientists create living bacterial photographs

...'camera'. Using Petri dishes full of genetically engineered E. coli instead of photo paper, students at The Un...ight on "biological film"--billions of genetically engineered E. coli growing in dishes of agar, a standard jello-like growth medium for bacteria. Like pixels o...

Restoring silenced suppressor gene kills lung-cancer cells

...ng WWOX protein. The researchers then used a virus engineered to carry working copies of the WWOX gene into the three cell lines. After five days, the researchers found that cells having an active WWOX gene died off. The cells self-destructed through a natural process known as programmed cell death, or apopto...

Stem cells' electric abilities might help their safe clinical use

...for human ESC-based therapies is the potential for engineered grafts to go haywire after transplantation and for...bility. In an earlier study, Li's lab genetically engineered heart cells derived from human ESCs, suggesting the possibility of transplanting unlimited supplies ...

Anti-cancer Compound In Beer Gaining Interest

...ts say, that hops might be produced or genetically engineered to have higher levels of xanthohumol, specifically to take advantage of its anti-cancer properties. Some beers already have higher levels of these compounds than others. The lager and pilsner beers commonly sold in domestic U.S. brews have fairly low...

HIV inserts into human genome using a DNA-associated protein

...s safer. The new findings about LEDGF suggest that engineered tethering interactions might some day allow control over integration site selection during gene therapy. According to Bushman, this finding is of particular importance in light of recent cases where integration of gene-therapy vectors near cancer gen...

UT Southwestern researchers develop screening test for cells that activate immune system

...ed the cell-based biosensor system. "We basically engineered DCs to express a fluorescent signal only when sensing activation signals so that you can identify immuno-stimulatory agents very easily," said Dr. Takashima. Immuno-stimulatory agents launch the immune system. The research appears on Blood magazine'...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

...ng FLT3 gene, on human dendritic cells and in mice engineered to mimic multiple sclerosis, a disease that causes T-cells to destroy the myelin protein sheath around nerves in the central nervous system. The drug had a similar effect on dendritic cells, causing most of them to die. In the mouse model, investigat...

Scientists closer to new cancer detection method

...ademy of Sciences, involve introducing molecularly engineered strands of DNA into cell cultures and observing wh... It works by capitalizing on fluorescent molecules engineered into tiny strands of DNA or RNA. Known as aptamers, the strands act as molecular beacons, correspond...

New antibody shows promise as cure for anthrax

A new anthrax antibody engineered by scientists at The University of Texas at Austin protects and defends against inhalation anthrax without the use of antibiotics and other more expensive antibodies. The high-affinity antibody, an anthrax antitoxin, successfully eliminated both ant...

Neurotransmitters signal aggressive cancer, offer potential for early diagnosis

...sive neuroendocrine prostate tumors in genetically engineered mice. Along with GABA, two other substances were seen, one a related neurotransmitter and the other a plant growth hormone with an unknown function in animals. Furthermore, the researchers found that the tumors made GABA using a different set of bioc...

Genetically modified maize not found in southern Mexico

...e the government's ban on planting the genetically engineered grain, other unpublished studies confirmed that GM... farmers in Mexico are allowed to grow genetically engineered crops such as cotton and soybeans. Over the two-year study, the researchers gathered more than 153,...

UCLA scientists reveal how Nipah virus infects cells

...he bait. To confirm their findings, the UCLA team engineered a harmless virus with Nipah virus proteins embedded in its coat. The decoy virus successfully infected cells vulnerable to the Nipah virus, but could not infect Nipah-resistant cells. In the final step, the decoy virus entered nerve cells and cells ...

Molecular trigger for Huntington's disease found

...l nuclei. In studies of cell cultures and of mice engineered to have HD, the researchers found that the p53 inc...resses damage to neurons in the eye of fruit flies engineered to have the abnormal HD protein. And in mice with the abnormal protein, knocking out p53 corrects be...

Variant prion protein causes infection but no symptoms

...the scientists observed 128 transgenic mice--those engineered to produce prion protein without a glycophosphoinositol (GPI) cell membrane anchor--for 500 to 600 days and saw no signs of scrapie disease. Subsequent electron microscopic examinations at UCSD, however, confirmed that they produced amyloid fibrils, ...

Columbia scientists develop cancer terminator viruses

...o papers about promising research with genetically engineered viruses studied in mice, published today in the journals Cancer Research and the Proceedings of the National Academy of Sciences (PNAS), bring us significantly closer to this objective and the start of clinical trials with these viral-based therapies...

Flies on speed offer insight into the roles of dopamine in sleep and arousal

... new work, the researchers showed that genetically engineered flies whose dopamine cells could be turned off experimentally, or flies that have received dopamine inhibitors, show converse behavioral effects to those seen in normal flies that have ingested methamphetamine. The results suggest that the right bala...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

... in mouse modelsIn mice, that had been genetically engineered to develop Alzheimer's disease, scientists were ab...ymptoms of the disease unless they are genetically engineered to do so. Amyloid plaques, which are insoluble protein clumps in the brain, can precede the onset o...

Breakthrough in micro-device fabrication combines biology and synthetic chemistry

...d yield unprecedented breakthroughs in genetically engineered microdevices (GEMs) for biomedical, computing, environmental cleanup, defense and numerous other applications. Conventional microfabrication processes, similar to methods used to make computer microchips, are expensive (i.e., capital equipment inte...

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