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Tag: "engineered" at biology news

Rare Tibetan antelope listed as endangered

...ed ever smaller ultrasound arrays, the researchers engineered probes that could fit inside catheters threaded through blood vessels to image the vasculature and heart from the inside out. The current advance relies on 500 tiny cables and sensors packed into a tube 12 millimeters in diameter ? the size required...

3D ultrasound device poised to advance minimally invasive surgery

...ed ever smaller ultrasound arrays, the researchers engineered probes that could fit inside catheters threaded through blood vessels to image the vasculature and heart from the inside out. The current advance relies on 500 tiny cables and sensors packed into a tube 12 millimeters in diameter ? the size required...

Stem cells from muscles can repair cartilage

...sing muscle-derived stem cells (MDSCs) genetically engineered with a therapeutic protein in an effort to repair ...been cultured from 3-week-old rats and genetically engineered to express bone morphogenetic protein-4 (BMP-4). Group 3, the control group, was treated with fibrin...

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

..."We have taken a very deadly toxin and genetically engineered it to be safe and to induce protective immunity in humans." Dr. Vitetta's work with ricin received international attention when she and a team of UT Southwestern researchers in the Cancer Immunobiology Center developed the experimental vaccine for t...

Interactive 3-D atlas of mouse brain now available on web

...ive anatomical comparisons with other, genetically engineered mouse strains," said project leader Helene Benveniste, who is a researcher in Brookhaven's medical department and a professor of anesthesiology at Stony Brook University. The database was created using high-resolution magnetic resonance (MR) microsc...

MicroRNA may have fail-safe role in limb development

...he research is to observe limb development in mice engineered to not express miR 196. "The authors have shown a role for miR 196 in limb development," said John Fallon, the University of Wisconsin's Harland Winfield Mossman professor of anatomy. "People talked about ways microRNA may have a role in embryonic d...

Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain

...leagues describe experiments that demonstrate that engineered human brain progenitor cells, transplanted into th...tor cells from human fetal brain tissue. They then engineered the cells to produce a growth factor known as glial cell line-derived neurotrophic factor (GDNF). In...

The brain is broadly wired for reproduction

...developed for charting neural pathways. They first engineered mice in which GnRH neurons produce barley lectin (BL), a tracer molecule that travels upstream and downstream to connected neurons, and green fluorescent protein (GFP), to mark the producing cells. By visualizing the locations of BL, GFP, and GnRH ne...

Cancer support cells may evolve, fuel tumor growth, study shows

...Their series of experiments involved a genetically engineered mouse model of prostate cancer developed in Van Dyke's UNC laboratory. The researchers manipulated epithelial cells ?the target cell type for prostate cancer ?causing them to divide at an accelerated rate. First, they found that this accelerated div...

Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects

... without side effects," Holtzman says. The group engineered a mutant Stat1 protein in which the identities of ...In addition, the group is studying transgenic mice engineered to carry the same Stat1 mutations that were examined in cells. In this way, the researchers can inve...

Algal protein in worm neurons allows remote control of behavior by light

...researchers went on to show that expression of the engineered ChR2 in mechanosensory neurons, which respond to touch by activating a reflex that causes worms to back up, was sufficient to prompt the backing behavior in response to blue-light exposure. In fact, the ChR2 expression in mechanosensory neurons allow...

Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method

...m. But in a series of experiments with genetically engineered mice, a team of researchers from the Howard Hughes...e cells whose DNA included "reporter genes," genes engineered to help concentrate chemical tracers detectable by PET imaging. The experiments conducted by Witte'...

PET imaging reveals the immune system at work

...m. But in a series of experiments with genetically engineered mice, a team of researchers from the Howard Hughes...e cells whose DNA included "reporter genes," genes engineered to help concentrate chemical tracers detectable by PET imaging. The experiments conducted by Witte'...

Cells from amniotic fluid used to tissue-engineer a new trachea

...ls to differentiate into cartilage cells. When the engineered grafts were ready, they were used to reconstruct d...hymal stem cells from amniotic fluid, Fauza's team engineered a tendon patch for the diaphragm; a year later, the lambs' diaphragms showed good healing. The FDA...

Bugs expose underground carbon traffic system 10 times more important than fossil fuel burning

...e researchers developed novel soil cores that were engineered with openings covered by nylon mesh with tiny pores just big enough to allow AM mycelia to grow into them but too small for any insects or other micro-fauna (including Collembola, soil mites) to get into the cores. The cores were then filled with s...

New GM mosquito sexing technique is step towards malaria control, report scientists

... responsible for much of the malaria in Asia. They engineered the mosquito larvae to express an enhanced green fluorescent protein (EGFP). The modified larvae were mixed with normal larvae, and the researchers were able to identify the modified male mosquitoes by their fluorescent gonads. When the genetically ...

Penn study finds direct role for glial cells in brain cross-talk

...ow astrocytes function in the brain. The mice were engineered to produce a protein called SNARE in their astrocytes. When the SNARE protein was produced, the amount of adenosine decreased. When adenosine accumulated, nerve impulses were suppressed and could not be transmitted across the synapse. This helps e...

Researchers quantify more noise in gene expression

...group measured the noise floor by used genetically engineered strains of yeast with a green fluorescence marker linked to a gene involved in the metabolism of the sugar galactose. The galactose gene and 10 others were chosen because they are expressed in yeast cells in high copy numbers, a feature that makes in...

New view of cancer: 'Epigenetic' changes come before mutations

...United States, Sweden and Japan reported that mice engineered to have a double dose of insulin-like growth factor 2 (IGF2) had more primitive precursor cells in the lining of the colon than normal mice. When these mice also carried a colon-cancer-causing genetic mutation, they developed twice as many tumors as ...

Polymer gel can block toxic leakage problem in gene therapy

...ble method to arrest toxic leakages of genetically engineered viruses that have plagued attempts to use gene therapy against cancerous tumors. The problem has been that viruses carrying anti-tumor genes have tended to leak from tumors, proving toxic to other body tissues. The researchers have developed a bioco...

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