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Tag: "engineered" at biology news

Heparin prepared synthetically could replace animal-derived drug

...arin by developing a large-scale process involving engineered enzymes and co-factor recycling. The new, scaleable process can be applied to synthesize other heparin-based structures that regulate cell growth and may have applications in wound healing or cancer treatment, according to the researchers. The findin...

Genetically engineered mosquitoes show resistance to dengue fever virus

...esearchers have successfully created a genetically engineered mosquito that shows a high level of resistance aga...engue infection. They also were able to detect the engineered RNA in the mosquitoes, a sign that the genetic alteration had been successful and passed down throug...

Jefferson researchers building a better rabies vaccine

..., who led the work. "As a result, we think we have engineered a virus which is nonpathogenic and extremely stable." Reporting recently in the Journal of Virology, Dr. Dietzschold, Matthias Schnell, Ph.D., associate professor of microbiology and immunology at Jefferson Medical College, and their co-workers iden...

Mice with glowing hearts shed light on how hearts develop

Cornell researchers have genetically engineered mice whose hearts glow with a green light every ti...hts for heart repair. In the study, the mouse was engineered to express a specially designed molecule that fluoresces when calcium, which increases dramatically ...

Gut protein found to protect against infection and intestinal breakdown

...e in protecting the small intestine. Genetically engineered mice that lacked FXR showed overall damage to the intestines, "strong evidence that this protein is crucial," Dr. Kliewer said. Drugs that bind to FXR, he said, could eventually become useful in treating various conditions of the small intestine. O...

Mice lacking social memory molecule take bullying in stride

...ute of Mental Health (NIMH) have discovered. Mice engineered to lack this memory molecule continued to welcome strangers in spite of repeated social defeat. Their unaltered peers subjected to the same hard knocks became confirmed loners ?unless the researchers treated them with antidepressants. "For both mi...

Gene-specific Ebola therapies protect non-human primates from lethal disease

...fic therapies for known, emerging, and genetically engineered pathogens. In today's online issue of the journal Public Library of Science Pathogens, a research team led by Sina Bavari and colleagues at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) reports using novel "antisense" d...

Scientists reveal how deadly toxin hijacks cells

...t result, they acquired mice that were genetically engineered to carry reduced amounts of SV2. Without that protein around, the researchers found that botox was unable to wreak havoc. Co-author Felix Yeh, a UW-Madison graduate student who works with Chapman, says that researchers have so far found three of the...

Formation of cellulose fibers tracked for the first time

...rhardt and Stanford graduate student Alex Paredez, engineered plants to produce a fluorescent version of cellulose synthase, the enzyme that creates cellulose fibers. They also included a fluorescent version of tubulin, the protein from which microtubules are built. Using an imaging technique that can track the...

New cellular flaw found in some virulent breast cancers

...cer without harming the patient. Previously, mice engineered to lack cyclin D1 were found to be highly resistant to certain breast cancers, and other experiments showed that mice in which the cyclin D1 gene had been inactivated developed into more or less normal adults. However, said Sicinski, it is difficult...

Engineered mouse mimics cognitive aspects of schizophrenia

...izophrenia--"afford a basis for optimism" that the engineered mice could provide an animal model for schizophren...rexpressed only in the striatum. What's more, they engineered the mouse strain so that they could shut down this overexpression by giving the mice the antibiotic ...

How taste response is hard-wired into the brain

... In the most telling experiments, the researchers engineered flies so that the hot pepper compound capsaicin wo...ot pepper taste. The researchers found that flies engineered to recognize capsaicin on the sweet-tasting neurons were attracted to the chemical, while those that...

'Nano-keys' bind cell receptors and trigger allergic reactions

...p cell membranes) bilayer. The surfaces, which are engineered on the micron scale (0.000001 meter; there are 25,...l what the cell sees. The cells are binding to the engineered surfaces and getting turned on. We can then see how the cell is organizing itself due to the stimulu...

UW-Madison engineers squeeze secrets from proteins

...in gets out protein." The idea behind this is that engineered enzymes are at work in the wash breaking down elements of a stain. "Once a protein is folded, you can actually unfold it or destabilize it, either by heating it up, or by adding solvents to the system, like urea for example, that just destroy the fo...

Mayo Clinic collaboration discovers protein amplifies DNA injury signals

...gene in mice and compared them to normal mice. The engineered strain of mice lacking MDC1 was extremely sensitive to DNA damage -- and unable to repair it. The MDC1-deficient mice showed symptoms of growth retardation, male infertility, immune defects and chromosome instability. The Next Step Now that they ...

Scientists design potent anthrax toxin inhibitor

...t of the National Institutes of Health (NIH), have engineered a powerful inhibitor of anthrax toxin that worked well in small-scale animal tests. "This novel approach to the design of anthrax antitoxin is an important advance, not only for the value it may have in anthrax treatment, but also because this tech...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

...r glycoproteins at large scale using the company's engineered yeasts. GlycoFi has already announced several major collaborations aimed at applying its technology to the production of specific therapeutic proteins, including collaborations with Merck, Eli Lilly and others. ...

Rice bioengineers pioneer techniques for knee repair

...l trying to perfect the mechanical strength of the engineered meniscus tissue, which must be able to withstand up to an astounding 2,400 pounds per square inch of compressive pressure. ...

Pair of studies offer new clues to combat antibiotic resistance

...the Borstel Research Center in Germany genetically engineered a strain of E. coli so that it lacks its normal outer protective layer of lipopolysaccharides, complex structures that help them defend against antibiotic attack. Removal of this layer is believed to make E. coli and other gram-negative bacteria ...

Cellular scale drug delivery from the inside out

... the chemical bond holding the cap in place can be engineered to be unphased by chemicals present in normal cells. However, in cancer cells these chemicals, such as antioxidants, appear in much higher concentrations and would break the bonds on the caps and release the drugs. In this way, only cancer cells coul...

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