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Tag: "engineered" at biology news

Rehydrate -- your RNA needs it

...he world to engineer RNA for medical purposes. The engineered molecules, called RNA aptamers, are selected for their ability to bind to particular proteins involved in certain diseases, blocking key steps in the disease process. "It's likely that water helps mediate the binding between these aptamers and the...

Mouse mimics chronic leukemia, will aid drug development

...eveloped the mouse strain in 2002. The researchers engineered the animal so that key immune cells called B lymphocytes, or B cells, overproduce a protein called TCL-1. This overproduction causes the CLL-like disease, which develops about a year after birth, though how it does so is still unknown. Human CLL i...

RNA interference stops colon cancer spread in mice

...lls were implanted into the spleens of genetically engineered immune-deficient "nude" mice. They then injected siRNAs designed to prevent the production of two specific PI3K proteins into the mice. The result was a major reduction in the spread of colorectal cancer to the liver. Evers and the paper's other a...

Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet

...nd other fat-related human diseases. Genetically engineered mice, in which the pathway was constantly revved u... people who are overweight and out of shape. The engineered mice consumed an equally high-fat diet but did not gain weight, indicating that fat storage pathways...

Mice lacking key immune component still control chronic viral infections

...ponent of the immune system, a line of genetically engineered mice can control chronic herpes virus infections, researchers at Washington University School of Medicine in St. Louis have found. Scientists can't prove it yet, but they suspect the missing immune system component, a group of molecules known as th...

Speeding discovery of the 'human cancer genome'

...usally contribute to the disease." "Genetically engineered mice, by definition, develop more defined cancers ...e current study, Chin's group examined genetically engineered mice with melanoma that had developed an increased potential to spread, a process known as metastasi...

Researchers win money to develop breath test to detect breast cancer

...nd water pockets. The switchable surfaces can be engineered to stand up or lie down---imagine blades of tall grass before a strong wind blows them flat. The surfaces switch when electrical charges are applied to make the straight particles bend. When upright, the spaces between the particles are open, and wil...

Stem cells can repair torn tendons or ligaments

...t the Hebrew University Faculty of Dental Medicine engineered mesenchymal stem cells (MSCs), which reside in the bone marrow and fat tissues, to express a protein called Smad8 and another called BMP2. When the researchers implanted these cells into torn Achilles tendons of rats they found that the cells not ...

Experimental drug reverses key cognitive deficits, pathology in Alzheimer's

...(AD) reverses learning and memory deficits in mice engineered to have pathological hallmarks of the disease. What's more, the drug, called AF267B, reduces both of the pathologies--the brain-clogging buildup of protein "amyloid plaque" outside brain cells and the protein "neurofibrillary tangles" inside the cell...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

...s to develop this tracking ability and genetically engineered neural stem cells to transport several cytokines ?...erived neural stem-like cells (BM-NSC) genetically engineered to produce IL-23 were injected into intracranial gliomas and other areas of the brain. Treated anima...

'Prosthetic' retinal cells let blind mice see light

...h inherited retinal degeneration, researchers have engineered cells in the eye to be light sensitive that were not before. Using a harmless virus, they introduced a gene for a light-sensitive protein into "inner retinal neurons" in a strain of mice with photoreceptor deficiency that resembles the defect in such...

Man-made heart tissue improves cardiac performance

...neer blood vessels within the tissue of previously engineered heart muscle. Trials have resulted in significant...ghout the implanted sections. Further, the tissue engineered construct remained viable even after the three-week implantation period, maintaining cardiac specifi...

Proteins stop blood-vessel and tumor growth in mice

... cells into mice. The tumor cells were genetically engineered to produce either fibulin 3 or fibulin 5. Three weeks after the cells were implanted, developing tumors that produced the fibulins were approximately 24 percent to 45 percent smaller than the control tumors. "We are thrilled that the fibulins contin...

Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure

...that spawn irregular heart rhythms. Studies of the engineered cardiac tissue revealed that while electric shocks...The team then induced electrical activity in these engineered tissues as would occur in ventricular tachycardia and attempted to halt it with pace-setting pulses....

Sex chromosome genes influence aggression andmaternal behavior, say UVa researchers

...ed aggression and maternal behavior in genetically engineered mice. "Sex chromosome genes may not be the whole story that determines how aggressive or motherly we are, but they are a partof it." Rissman's work is published in the Feb. 22 issue of The Journal of Neuroscience, found online at www.jneurosci.org. ...

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

...er than ever before." Xencor's Fc variants were engineered using the company's XmAb TM technology, which couples computational design algorithms with high-throughput screening to rationally design the antibody constant region. The Fc portion of the constant region of the antibody has been shown in previous...

Report lists top 20 most-vulnerable African carnivores

...uorescence is quenched, or extinguished. So Jacobs engineered bacteria to produce fragments of the telomerase enzyme fused to the fluorescent protein. Since telomerase fragments that clustered together would drag along ?and quench ?their associated fluorescent protein, Jacobs knew that any bright green bacteria...

Groovy protein essential for promoting cancer development

...uorescence is quenched, or extinguished. So Jacobs engineered bacteria to produce fragments of the telomerase enzyme fused to the fluorescent protein. Since telomerase fragments that clustered together would drag along ?and quench ?their associated fluorescent protein, Jacobs knew that any bright green bacteria...

Tandem transcripts team together

...ns in drug development," says Sorek. "Recombinant engineered fused proteins are currently being developed as th...ad, in the future, to the development of non-toxic engineered fused proteins that could be used as drugs." ...

Hopkins researchers discover genetic switch that turns off an oxygen-poor cell's combustion engine

...uired to activate PDK. The team then genetically engineered HIF-1 null MEFs and forced PDK to work-even in the absence of the HIF-1 gene. The hypoxic cells once again accelerated glycolysis and produced increased amounts of ATP; and with the PDK forced to work, the cells were also able to shut down the TCA cy...

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