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Tag: "engineered" at biology news

Ghost protein leaves fresh tracks in the cell

...resh," he said. A laboratory fly was genetically engineered so that spectrin could no longer bind to ankyrin -...ly to the cell membrane." In fact, the genetically engineered flies often survived to adulthood, while mutants that lacked spectrin altogether died very early in ...

Mutant mice show key autism traits

...he animals' bodies. However, Parada and colleagues engineered mice to knock out the gene only in mature, or "postmitotic," neurons of the cerebral cortex and hippocampus in the brain. These regions are associated with higher brain function such as learning and memory. The mutant mice showed major abnormalities...

Tests may help answer questions about GMOs and allergies

The potential of genetically engineered foods to cause allergic reactions in humans is a b...the first animal model to test whether genetically engineered foods could cause human allergic reactions. Venu Gangur, MSU assistant professor of food science and...

Scientists discover that ancient genes dictate flowering, fall bud set

...- who have been doing research to make genetically engineered trees sterile so that they cannot cross with wild trees -- used consecutive years of poplar clones to study the multi-year delay in flowering. The Science paper reports their discovery that the expression of the FT gene increases with age. "This grad...

Blood-compatible nanoscale materials possible using heparin

...archers from Rensselaer Polytechnic Institute have engineered nanoscale materials that are blood compatible using heparin, an anticoagulant. The heparin biomaterials have potential for use as medical devices and in medical treatments such as kidney dialysis. The researchers prepared several materials with hepa...

Researchers find protein that silences genes

...is located in the cell, the group then genetically engineered the protein to include a fluorescent tag and found that much of the HDA6, seen as a glowing red signal under the microscope, shows up in the nucleolus, which is precisely the site where ribosomal RNA genes are regulated and where nucleolar dominance ...

Selectively blocking inflammatory signals may protect mice from MS

...une-mediated damage. But if stem cells could be engineered to resist harmful signals such as interferon-gamma, they might be protected from the "harsh environment" present in immune mediated demyelinated lesions, said Popko. ...

Bioengineered tissue implants regenerate damaged knee cartilage

...sity of Bristol. The study, "Maturation of tissue engineered cartilage implanted in injured and osteoarthritic ... 7) issue of Tissue Engineering, demonstrates that engineered cartilage tissue can grow and mature when implanted into patients with a knee injury. The novel tis...

Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's

...ts would alleviate the need for transplantation of engineered cells, and as a drug therapy, it would be also easy to administer to patients. Moreover, given that similar drugs exist, medicinal chemistry to maximize this effect could be achieved quickly," says Diane Murphy, Ph.D., the NINDS program director for...

C-myc required by the immune system

...ior author of the study. "By analyzing genetically engineered mouse models with reduced c-myc, reduced IL-15 or absent IL-15, we discovered that it's actually c-myc, which is known primarily as an oncogene, that acts downstream of the IL-15 signaling pathway to regulate T memory cell homeostasis." According to...

How bad is malaria anemia? It may depend on your genes

... When infected with plasmodium, mice genetically engineered to lack MIF experience less severe anemia and are more likely to survive. Without MIF around to prevent blood cells from maturing, the mice appear better able to maintain their oxygen carrying capacity and don't lose as much hemoglobin, the protein f...

Gene therapy injected into the brains' of mice with Huntington's disease

...contains any of its own genes. The vector has been engineered to transfer the gene for the brain nutrient selectively to the area of the brain where it is needed to protect the degenerating cells. Three groups of mice were involved in the 4 month study. All mice were modeled to have the genetics of HD. The HD...

Metal homeostasis research in plants will lead to nutrient-rich food and higher yielding crops

...ietary source of micronutrients. Therefore, plants engineered to be better sources of essential elements would o...n the crucial ability to transport Iron. When the engineered IRT1 alleles are expressed in plants that no longer express a wild type copy of IRT1, the engineered...

Defense peptide found in primates may block some human HIV transmissions

...elop a way to grow retrocyclin through genetically engineered tobacco plants. The retrocyclin gene would be incorporated into the chloroplast genome of tobacco cells before the plants grow. Daniell has developed a similar approach to growing anthrax vaccine in tobacco plants. An inexpensive way to produce the...

New roles for growth factors: Enticing nerve cells to muscles

...acking the sensor molecule. Finally, using mice engineered to express a fluorescent protein in MMCm neurons, the investigators demonstrated that only the glowing neurons extended axons in the direction of target cells expressing FGF. "After a lot of hard work, we narrowed it down to FGFs and showed that the...

Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein

...l shape and strength. By studying mice genetically engineered to lack K17, the Hopkins researchers discovered that cells need it to turn on signals that lead to the manufacture of new proteins and cell growth when skin is damaged. "Here we show an entirely novel and possibly independent, nonmechanical functio...

Research highlights how bacteria produce energy

...noma de Mexico announce that they have genetically engineered the bacterium Bacillus subtilis to directly ferment glucose sugar to ethanol with a high (86%) yield. This is the first step in a quest to develop bacteria that can breakdown and ferment cellulose biomass directly to ethanol. "Currently ethanol is ...

UT Southwestern researchers find gene mutation that leads to 'broken hearts'

...entify genes that cause human heart defects. "We engineered a fruit fly so that the heart would glow in the da...n order to do that, the UT Southwestern scientists engineered fruit flies whose hearts glow by expressing a gene coding for green fluorescent protein specifically...

UC Davis researchers move biotechnology closer to replacing electronic pacemakers

...ted an adenovirus carrying a gene encoding for the engineered HCN protein into the heart muscle. Adenovirus has ...is team previously generated the first genetically engineered human heart cells from human embryonic stem cells, and demonstrated that they can be transplanted in...

Stanford doctors advance in bid to turn mice stem cells into blood vessels

...cell," Abilez explained. "This would be new for an engineered tissue. We hope our work with mouse stem cells could eventually be translated to human autologous adult stem cells." With an estimated 70 million Americans diagnosed with cardiovascular disease, the need for arterial vascular grafts continues to gro...

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