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Tag: "engineered" at biology news

'Trojan Horse' agent halts bone metastasis in mice

...llest of VEGF proteins (VEGF 121) to a genetically engineered toxin, gelonin, derived from a plant that grows wild in India, and used bacteria to produce the fusion protein. The agent is designed to enter new blood vessel cells in tumors through expressed VEGF receptors and, once inside, the "Trojan Horse" toxi...

An artificial cornea is in sight, thanks to biomimetic hydrogels

...es populating the periphery. Myung calls the pores engineered into his artificial cornea the "homes" he built for cells that need to infiltrate the artificial lens and integrate it with surrounding natural tissue. "If you build it, they will come," Myung says. "The cells move in, and they bring furniture too-...

Engineer ramps up protein production, develops versatile viral spheres

...nnovations in his lab, the cell-free production of engineered viral capsids. The capsids are based on the outer ...hoping some consumers become interested. With an engineered capsid, in contrast, a vaccine maker could attach a very specific protein designed to stimulate only...

A fisheye view of the deadliest breast cancer

...and colleagues see their xenografted, genetically engineered zebrafish as a potential front runner. ...

Nanotech tools yield DNA transcription breakthrough

...nd, in the former Soviet Union, were intentionally engineered to be resistant to current antibiotics. Ebright explained that his laboratory at Rutgers' Waksman Institute of Microbiology has two parts: One part seeks a fundamental understanding of the machine; the other uses that understanding to develop new ...

Human stem cells delay start of Lou Gehrig's disease in rats

...e research team used so-called SOD-1 rats, animals engineered to carry a mutated human gene for an inherited form of ALS. As in human ALS, the rats experience slow nerve cell death where all the muscles in the body eventually become paralyzed. The particular SOD-1 rats in the study developed an "especially agg...

'Tribbles' protein implicated in common and aggressive form of leukemia

...vidence implicate Tribbles in AML. First, all mice engineered to express Tribbles-2 (Trib-2) in hematopoietic stem cells developed AML. They also found that Trib-2 inhibited C/EBPá, another protein that is frequently mutated in AML patients. Additionally, expression of the Tribbles protein was elevated in blood...

UCSD researchers create roadmap to integrin activation

...process," said Ginsberg. When cultured cells were engineered to express GPIIb-IIIa, agents that usually activat...IIIa." Using a synthetic approach, the scientists engineered an integrin-activated pathway. By adding protein kinase C, talin or mutants to manipulate the syste...

Innovative movies show real-time immune-cell activity within tumors

...tion, for this study, tumor cells in the mice were engineered to fluoresce blue. In one group of the mice, a vaccine developed by Wistar professor and study co-author Hildegund C.J. Ertl, M.D., was used to activate the T cells that recognize a molecule on the surface of the tumor cells. Such molecules are re...

Cardiologist's 'living chip' changes science of disease monitoring

...ksUltimately, cells specific to the patient can be engineered to live on and function as part of the miniature electronic chip. The wireless biosensor is placed within and around blood vessels and nerves to provide detection and stimulation of the surrounding tissues or organ systems, with the ability to detect...

Researchers discover new gene responsible for brittle bone disease

...udy Details In the study, mice were genetically engineered by the Baylor team with the CRTAP gene removed, an...ized the skeletal abnormalities in the genetically engineered mice and carried out studies of bone cells from the mice as well as detailed microscopic analysis of...

Restoring tamoxifen sensitivity in resistant breast cancer cells

...resistance by using the compound in mice that were engineered to have tamoxifen-resistant tumors and saw that tumor growth was reduced by nearly 50 percent when DIBA was administered. "Exposure to DIBA causes certain physical changes to occur between the estrogen receptor and the biological machinery that sti...

Researchers use multiphoton microscopy to watch chromosomes in action

...vated," said Webb. Using another method that Webb engineered at Cornell, called fluorescence recovery after photobleaching, the researchers also discovered that HSF activators bind to hsp70 genes much longer than previously thought before being replaced with new HSFs, which raises new questions about the mecha...

Most widely used organic pesticide requires help to kill

... the genes that make Bt's toxic proteins have been engineered into numerous crop plants. Transgenic crops using ...he bacterium's genes are the most prevalent of any engineered plants, and are planted on millions of acres in the United States alone. Although Bt and the toxic...

Cell death following blood 'reflow' injury tracked to natural toxin

...lse) killed them, they examined the brains of mice engineered to lack an enzyme that chews up and gets rid of PAR. These mouse brains contained twice as much PAR-polymer as those of normal mice. After the researchers induced a blood clot injury like a stroke, the same mice showed a 62 percent increase in the...

Targeted virus compels cancer cells to eat themselves

An engineered virus tracks down and infects the most common and deadly form of brain cancer and then kills tumor cells by forcing them to devour themselves, researchers at The University of Texas M. D. Anderson Cancer Center report this week in the Journal of the ...

New mechanism explains glucose effect on wakefulness

...o unknown." In their experiments, the researchers engineered mice to produce a fluorescent protein only in orexin neurons. Thus, the researchers could isolate the neurons in brain slices from the mice and perform precise biochemical and electrophysiological studies to explore how glucose acted on those neurons...

Eat less, weigh more? Enzyme makes lean mice 'susceptible' to dietary fat

Working with genetically engineered mice, Johns Hopkins scientists have interfered with the brain's ability to control an animal's response to a high-fat diet. The report, to be published in the latest issue of the Proceedings of the National Academy of Sciences online the week of May...

Test reveals effectiveness of potential Huntington's disease drugs

... spiny neurons from the brains of mice genetically engineered to express the mutant human Huntington gene. As predicted, glutamate killed the Huntington's neurons, but the scientists also tested five clinically relevant glutamate inhibitors to assess their protective ability. Folic acid has been suggested as...

3-D ultrasound scanner could guide robotic surgeries

...ed ever smaller ultrasound arrays, the researchers engineered probes that could fit inside catheters threaded through blood vessels to view the vasculature and heart from the inside. Earlier this year, the team reported another advance: a 3-D ultrasound device including 500 tiny cables and sensors packed into...

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