engineered 2 10

Tag: "engineered" at biology news

Genetically engineered animals help in scientific research that may benefit children

...nic kidney disease. The combination of genetically engineered animals and this animal model has helped us to decide which molecules to study, or which might be interesting targets for drug development in human chronic kidney disease." Obstructive nephropathy or obstructive uropathy, the kidney disease on which...

Hopkins scientists uncover 'tags' that force proteins to cell surface

...proteins, and its existence helps explain why some engineered proteins don't go where they're supposed to go, Li says. "If you remove a small part of the very end of a protein, it seems unlikely to disrupt how the rest of the protein folds in a three-dimensional structure, but that's what most scientists thin...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...ted human skin tissue containing cells selectively engineered to express specific mutations found in melanoma. T... in the deepest layer of the skin. The genetically engineered melanocytes were then combined with keratinocytes, the cells that give skin its structure, to form a...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...ted human skin tissue containing cells selectively engineered to express specific mutations found in melanoma. T... in the deepest layer of the skin. The genetically engineered melanocytes were then combined with keratinocytes, the cells that give skin its structure, to form a...

Engineered skin offers clues to melanoma development

...ted human skin tissue containing cells selectively engineered to express specific mutations found in melanoma. T... in the deepest layer of the skin. The genetically engineered melanocytes were then combined with keratinocytes, the cells that give skin its structure, to form a...

Elderly mice yield clues to the process of growing old

... into the molecular subtleties of a strain of mice engineered to age rapidly, scientists have found that an accu...an mice. Prolla suggests that new studies of mice engineered to have fewer than normal mitochondrial DNA defects or improved mitochondrial function may pave the ...

Structures of marine toxins provide insight into their effectiveness as cancer drugs

... of the ocean floor, meaning that the drugs can be engineered to be as effective as possible. "In order to chemically synthesize a better drug, it is a good idea to know how the natural compound works," he says. "Scientists who study natural products take their cues from what nature has already done. We're a...

A novel method to measure circadian cycles

...ted subsequently made tissue cultures with a virus engineered to report with a fluorescent signal when a certain host circadian rhythm gene was expressed. They found that their data jibed with the previously accepted length of the human circadian cycle: 24.5 hours. Because of the sensitivity of their method, S...

Engineered molecule amplifies body's immune response

...r initial in vitro results were promising, and the engineered Stat1 molecule exhibited an increased responsiveness to interferon. Following up on these discoveries, Dr. Holtzman and his colleagues are currently performing gene transfer experiments, using both recombinant viruses and transgenic mice, to establis...

'Jumping genes' contribute to the uniqueness of individual brains

... Then they introduced it into mice. Every time the engineered L1 element jumped, the affected cell started glowing green [WHY?]. "We were very excited when we saw green cells all over the brain in our mice," says research fellow and co-author M. Carolina N. Marchetto, "because then we knew it happened in vivo a...

Gene therapy advance treats hemophilia in mouse models

...d, partial correction to bleeding problems in mice engineered to have Hemophilia A, which is also known as factor VIII deficiency. The findings appear in the Sept. 1 issue of the journal Blood (published Aug. 19 online). The team adapted the outer layer, or "coat," from a baculovirus, a virus that infects bu...

New Discovery May Help Doctors Treat Infertility

...rove ovulation rates in mice that were genetically engineered to lack estrogen receptor beta. The estrogen receptor beta is one of two estrogen receptor proteins which mediate the effects of estrogen hormones and are present throughout the female reproductive tissues. These new data indicate that this receptor ...

Pinpointing a culprit molecule in Alzheimer's disease

...e in Alzheimer's disease (AD) research is why mice engineered to have the abnormal protein underlying the disease in humans show little pathology of the disease. Specifically, such mice are genetically altered to overproduce mutant human amyloid precursor protein (APP). It is this protein that, when clipped by ...

Redesigned protein accelerates blood clotting

...rrent preventive treatment consists of genetically engineered factor VIII administered by injection, but one quarter of those born with no factor VIII suffer severe immune reactions that render the treatment inactive. In addition, current treatment costs as much as $200,000 per patient per year. Researchers at ...

Researchers track down cause of a disfiguring bone disorder

...he SOST gene, Loots and her colleagues genetically engineered a copy of the DNA segment containing the gene and used it to generate mice with and without the 52,000-base-pair region missing in Van Buchem patients. The deleted region is located about 35,000 base pairs "downstream" from SOST on human chromosome 1...

Climate model links higher temperatures to prehistoric extinction

...tation as the first strain, but that had also been engineered to prevent IFNγ production, were found to have almost as many mast cells as normal mice, if not more. They concluded that the presence of high IFNγ levels blocked mast cell development. ...

VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease

...tation as the first strain, but that had also been engineered to prevent IFNγ production, were found to have almost as many mast cells as normal mice, if not more. They concluded that the presence of high IFNγ levels blocked mast cell development. ...

Attacks of King George III's madness linked to key metabolism molecule

...a series of experiments with normal mice and those engineered to lack the PGC-1 alpha gene, the researchers said they have provided "a clear-cut mechanism" linking fasting to an increase in PGC-1 alpha, and, in turn, overactivity of the ALAS-1 gene. The therapeutic effect of glucose and high-carbohydrate diets ...

Insects develop resistance to engineered crops

...gle plant efficiently kill insects. But when crops engineered with just one of those toxins grow nearby, insects...." Cotton and maize are the only commercial crops engineered with Bt genes. In 2004 these crops were grown on more than 13 million hectares (about 32 million acr...

New complete muscle grown in the lab

... might provide the "seed" cells for a person's own engineered replacement muscle. For example, the lab-grown mus...now, most scientists have not attempted to provide engineered tissue with its own blood supply. Instead, they have implanted the new tissue into the body and wait...

1 2 3 4 5 6 7 8 9 10