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Tag: "elevated" at biology news

Prenatal nicotine exposure reduces breathing response of newborns...

... after it was determined by low glucose levels and elevated white blood cell counts in her amniotic fluid that she had an infection. An examination of the placenta, fetal lining and umbilical cord following the birth supported the infection. Han's tests of the amniotic fluid found the Bergeyella bacteria. ...

Weighting cancer drugs to make them hit tumors harder

... the drug to concentrate." Even drugs with vastly elevated molecular weights � 2 million molecular weight -- achieved better concentrations in tumors than a lower molecular weight, the study showed. Chilkoti said chemotherapy by itself is small enough to travel throughout the body via the bloodstream, cau...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

...activating its receptor and certain tumors exhibit elevated levels of EGFR. In addition, activated EGFR have been implicated in the development and spread of several human cancers, including cancers of the colon, ovary, breast and lung. Wave Basics Waves are circular ruffled surface structures on the exte...

Speeding discovery of the 'human cancer genome'

...ir invasive ability revealed just one consistently elevated protein, called Nedd9. To find out whether Nedd9 could play a role in skin cancer's spread, the researchers blocked the protein in both mouse and human metastatic melanoma cells. Cancer cells without active Nedd9 lost their ability to invade. Simi...

First human study confirms that immune cells can be a primary cause of bone loss in gum disease

...eriodontally diseased patients mount significantly elevated antibody levels to bacteria colonizing around gum ...s) in a laboratory culture system, in spite of the elevated presence of B and T lymphocytes. Since it has never been reported that any bacteria per se invade an...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

...elated to the free radical NO, which is present in elevated levels in neurodegenerative diseases, attacks PDI ...o show that this altered form of PDI is present in elevated amounts in patients with Alzheimer's and Parkinson's Disease, indicating that it is a potential mark...

Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet

...Mice genetically engineered to express permanently elevated levels of TRB3 protein in fat tissue were 10-20 percent skinnier than normal mice. "Even when we put them on a high-fat diet, these mice just didn't gain any weight," says Qi. "Their physical activity was the same, but they were constantly burning fa...

Research identifies protein in mice that regulates bone formation

...aired osteoclast activity, was responsible for the elevated bone mass. Osteoblasts are cells that form new bone. Jones, Wein and their colleagues found that Shn3 formed a complex with a protein known as WWP1; together, the pair degrades Runx2, a transcription factor that is the master regulator of osteoblast ...

Food-crop yields in future greenhouse-gas conditions lower than expected

...researchers to grow crops in open-air fields, with elevated levels of carbon dioxide simulating the composition of the atmosphere projected for the year 2050. SoyFACE has added a unique element by introducing surface-level ozone, which also is rising. Ozone is toxic to plants. SoyFACE is the first facility in...

Brain enzyme treatment relieves memory lapse in Alzheimer's mice

...n from transgenic mice with mutations that lead to elevated Aß and associated cognitive decline. The researchers next asked whether Uch-L1 played an important role in fear conditioning, a form of learning known to be impaired in several mouse models of Alzheimer's disease. For fear conditioning, mice tre...

Pollution threatens coral health by preventing lesions from healing, UCF study shows

...to be stressed by chemical contaminants, including elevated levels of fungicides, industrial chemicals and fue...e found at those sites. At three offshore sites, elevated levels of a multidrug resistance protein were found. That helps the coral defend itself against cont...

Researchers attack tumor cells by exploiting dependency on sugar metabolism

...equired for the glucose to lactate pathway that is elevated in human breast and lung cancers. Inhibition of LDH-A stimulated mitochondrial function and drastically compromised the ability of the tumor cells to proliferate in low oxygen conditions. Restoration of LDH-A activity reestablished the glycolytic phe...

Triple threat polymer captures and releases

...a favorable environment at room temperature but at elevated temperature for some reason everything is being expelled rapidly,," she said. "We don't know if there is some reorganization of the morphology of the material or whether the guests partition to different domains at different temperatures." Woole...

Beaver dams create healthy downstream ecosystems

...r of the valley. The researchers suggest that the elevated moisture levels found in soil surrounding the dams would otherwise require water from a very large natural flood, which they estimate as the 200-year flood, to achieve the same expansive water availability to the valley bottom. Additionally, beaver d...

Major cancer study aims to identify protein markers for early-stage disease

...SA) hint at the presence of prostate cancer, while elevated levels of cancer antigen 125 (CA-125) suggest possible cancer of the ovary or other organs. However, both tests have "false negatives" or "false positives," making them unreliable. If mass spectrometry can be refined and standardized, scientists say...

Adults who go to bed lonely get stress hormone boost next morning

...ts go to bed lonely, sad or overwhelmed, they have elevated levels of cortisol shortly after waking the next morning. Elevated levels of cortisol -- a stress hormone linked to depression, obesity and other health problems when chronic -- actually cue the body on a day-to-day basis that it is time to rev up t...

UCSD study reveals how plants respond to elevated carbon dioxide

...oxide from the burning of fossil fuels is that the elevated carbon dioxide will stimulate plants to grow faster. The assumption is that plants will take up excess carbon dioxide to produce carbohydrates--their stored energy source. However, studies have shown that, contrary to expectations, increased carbon...

Protowings may have helped bird ancestors cover rough terrain

...ars often use WAIR in preference to flying to gain elevated terrain, and exhausted birds always resort to WAIR. Dial and colleagues describe experiments showing that if the surface area of chukar wings is reduced by plucking or trimming the feathers, WAIR becomes less effective for climbing slopes. Dial and ...

High dopamine transporter levels not correlated with ADHD

... and interest. If, for example, ADHD subjects have elevated levels of dopamine transporters ?proteins on dopamine-producing cells that take up excess dopamine ?they could end up with depleted dopamine levels and reduced motivation/attention. Four independent studies have reported that ADHD subjects have hig...

For super-obese patients, duodenal switch beats gastric bypass

...s, including type 2 diabetes, high blood pressure, elevated cholesterol levels, acid reflux, and obstructive sleep apnea in these patients. We don't know yet how much weight loss we need to get those health benefits, but losing more of the excess weight certainly seems to be better." ...

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