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Tag: "elevated" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...ich in saturated fats and trans-fatty acids causes elevated blood levels of cholesterol and triglycerides and increases one's risk of heart disease and certain cancers. In the Jan. 28 issue of Cell, scientists led by Bruce Spiegelman, PhD, report that the harmful effects of saturated and trans fats are set i...

Enzyme shown to help protect genomic stability

...lomeres, has been linked to aging in humans and an elevated risk for aging-related diseases, the most prominent of which is cancer. For this reason, insights into the mechanisms of gene silencing could provide important guideposts for new approaches to retarding aging or treating cancer. Now, an investigatio...

Poplar trees redirect resources in response to simulated attack

... of external factors like insect attacks, disease, elevated carbon dioxide, soil toxins, and drought on vital plant processes." Ferrieri says scientists trying to improve plants' resistance to environmental challenges -- or their ability to perform useful tasks such as carbon sequestration, phytoremediation,...

Scientists rid stem cell culture of key animal cells

.... Experiments confirmed this to be true. Next, Xu elevated concentrations of FGF2, a protein routinely used for human embryonic stem cell culture, to test whether FGF2 preserves undifferentiated stem cells in the absence of BMP. The result was that "the cells looked perfect." Xu says he has grown the resulti...

Researchers discover molecule that causes secondary stroke

...sospasm. The same patients were also found to have elevated levels of bilirubin and significantly higher levels of BOXes. One of the 12 who had elevated bilirubin, but hardly any BOXes, did not experience a secondary stroke. When bilirubin is elevated,...

Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease

...g on the chemical bonds that hold together the two elevated monomers. By pulling on such bonds, the Duke scientists can deduce how much energy was required to bring the molecules together. Then, using their knowledge of protein chemistry, they can develop hypotheses about how those particular monomers might,...

White blood cell waste disposal system plays critical regulatory role

...e they would have encountered phagocytes exhibited elevated IL-23 and IL-17 levels. When these mice received an infusion of normal neutrophils that were capable of migration, the levels of IL-23 and IL-17 dropped considerably. The researchers conclude that a major mechanism for regulation of neutrophil produ...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...e also occurs in human lymphoma patients. Combined elevated TEL2 and MYC expression occurred in the B lymphocytes of over a third of patients with a B lymphoma called B-acute lymphoblastic leukemia. "These results offer new hope for improved diagnosis," said Monica Cardone, Ph.D., a postdoctoral student in G...

Chemists identify key gene in development of type 1 diabetes

...ry protein that they showed in previous studies is elevated in diabetic animals and may be involved in the cascade of immunological events that leads to the destruction of the pancreas and the subsequent onset of type 1 diabetes. The disease is much less common than type 2 diabetes, formerly known as adult on...

Towards precise classification of cancers based on robust gene functional expression profiles

...ry protein that they showed in previous studies is elevated in diabetic animals and may be involved in the cascade of immunological events that leads to the destruction of the pancreas and the subsequent onset of type 1 diabetes. The disease is much less common than type 2 diabetes, formerly known as adult on...

Surprising findings reported about iron overload

...ies of the C282Y mutation of the HFE gene also had elevated levels of iron in their blood. * Men who had two copies of the C282Y mutation of the HFE gene were more likely to report a history of liver disease than participants without HFE mutations. "Our findings in Caucasians confirm reports from previou...

Hirsute Or Hairless? Two Proteins May Spell The Difference

...tant littermates. Conversely, transgenic mice with elevated TGF-β2 signaling activity displayed ectopic expression of Snail. Knockout mice lacking TGF-β2 also showed higher levels of E-cadherin—normally down-regulated by Snail—than their nonmutant littermates. Altogether, these findings suggest that TGF-β2 s...

Antiretroviral therapy may prevent excess risk of some cancers in people with HIV

...th HIV. People with HIV in the study had a highly elevated risk of Kaposi sarcoma and non-Hodgkin lymphoma. They also had an increased risk of anal cancer, Hodgkin lymphoma, cervical cancer, liver cancer, cancer of the lip, mouth, and pharynx, and non-melanoma skin cancer. People who used HAART had lower ris...

Scientists identify molecule that regulates well-known tumor suppressor

...ival. In cancer cells from breast cancer patients, elevated PKB/Akt activity and reduced PTEN expression were associated with elevated DJ-1levels. DJ-1 levels were increased in cells from lung cancer patients, and DJ-1 was associated w...

Survey finds silver contamination in North Pacific waters

...metal contamination in San Francisco Bay, said the elevated silver concentrations in the open ocean suggest there may be "hotspots" in Asian coastal waters where the concentrations reach toxic levels. "The open ocean is vastly diluted, so there may be some massive hotspots of silver contamination around the ...

Defenseless plants arm themselves with metals

...tal hyperaccumulators, however, have significantly elevated salicylic acid in their tissues all the time. In ... hand, is brimming with glutathione, thanks to its elevated salicylic acid levels. When grown in nickel-enriched soil, Thlaspi takes up 3 percent of its body we...

White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

...e they would have encountered phagocytes exhibited elevated IL-23 and IL-17 levels. When these mice received an infusion of normal neutrophils that were capable of migration, the levels of IL-23 and IL-17 dropped considerably. The researchers conclude that a major mechanism for regulation of neutrophil produ...

Test for early detection of prostate cancer shows promise

...cancer patients and none of the other patients had elevated EPCA levels, suggesting that for this study, the t...of patients who undergo biopsies because they have elevated PSA values are actually positive for prostate cancer, while as many as 15 percent of those with low ...

Scientists journey to southern Africa to unravel the secret world of elephant communication

... construction of the campsite, which included four elevated tents, a cooking/dining area and a 20-foot-tall, two-story observation tower with a commanding view of the waterhole and surrounding scrubland. Sitting in the upper level of the tower, O'Connell-Rodwell and Katie Eckert pay close attention to the wi...

Measuring hormone cuts antibiotic use in half in pneumonia patients

...ause levels of procalcitonin have been found to be elevated in patients with bacterial infection but not viral infection or other inflammatory diseases, Dr. Tamm and colleagues decided to study whether measuring levels of the hormone could eliminate or reduce antibiotic use in patients with bacterial pneumoni...

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