Statin plus cancer drug deliver combo punch to brain cancer cells
...humans and animals. Its connection to anti-cancer efforts grew out of later insights into its blockage of hedgehog, which gets its name from spiky hairs that develop on fruit flies lacking the signal. "We already knew from earlier research that hedgehog controls brain cell survival and growth, and that bl...New research may overturn conventional wisdom on drug-resistant tuberculosis
...Our findings highlight the urgency of accelerating efforts to interrupt the transmission of drug-resistant tuberculosis." The research shows improved methods of preventing TB transmission may be needed in the very facilities and communities where TB patients are treated. Fast Facts Tuberc...NIH announces phase III clinical trial of creatine for Parkinson's disease
...d to include a broad range of people, with special efforts to recruit a diverse population that is similar to the makeup of the population with PD in the United States. The investigators will measure disease progression using standard rating scales that measure quality of life, ability to walk, cognitive ...Natural polyester makes new sutures stronger, safer
...researchers focused their "biopolymer engineering" efforts on a group of genes that code for enzymes in a pathway that produces polyesters. Those polyesters can be broken down into metabolites naturally produced by humans, so they cause no harm when absorbed. Once the genes were identified, they could be ...Leukemic cells find safe haven in bone marrow
...recurrence rate of ALL and continue our successful efforts to increase the survival rate of ALL." Previous research at St. Jude and elsewhere had shown that direct contact with bone marrow mesenchymal cells is essential for the long-term survival and multiplication of leukemic lymphoblasts. In the curren...Scripps Research study reveals new activation mechanism for pain sensing channel
...hannel activation," Macpherson said. "Our research efforts are now aimed at further understanding how binding of these compounds activate the channel, and identifying the physiological role of TRPA1 in sensing oxidative stress." The protein is currently being investigated by several pharmaceutical companies ...Over a century after disappearing, wild elk return to Ontario
...ld elk have returned to the province thanks to the efforts of the Ontario elk restoration program. According to a report on the program’s success, published in the March issue of Restoration Ecology, 460 elk were brought from Alberta and released in various Ontario sites between 1998 and 2001. "The Ontario ...Targeting tumors the natural way
... The team got the idea to mimic this process from efforts to transplant pig organs into primates. The surfaces of most mammalian and bacterial cells express large amounts of a carbohydrate, called alpha-Gal in scientific shorthand, while the cells of humans and other higher primates do not. What humans and ...Linheng Li Lab documents the development of cancer stem cells
... "All of us were very excited to be part of these efforts to reveal basic features of cancer stem cells," said Dr. He. "What we learned -- that cancer stem cells are a rare population in the tumor mass; that they are slow cycling but more active than normal stem cells; and that cancer stem cells and stromal...1/3 of sexually active older adults with HIV/AIDs has unprotected sex
...ve unprotected sex, which suggests that prevention efforts may need to be more highly targeted toward these individuals. The behavioral information was pulled from a survey of 260 HIV-positive older adults who were participating in a study examining support groups. The study was funded by a three-year, ...Scientists identify specific enzymes that make meningitis hard to fight
...nct functions - work together to hamper the body's efforts to fight off the disease. Together they repair damage done to the meningitis bacteria's DNA by the body's white blood cells, which are sent to fight the infection. Understanding the part these enzymes play in the process that enables the bacteria ...Ocean's 'twilight zone' may be a key to understanding climate change
... "These results are particularly important to our efforts today to improve the predictive capacity of numerical models that relate ocean carbon to global climate change on different time scales," said Don Rice, director of NSF's chemical oceanography program. It also adds a new wrinkle to proposals to m...Scientists discover new species of distinctive cloud-forest rodent
...le is known about its lifestyle because subsequent efforts to locate and observe the animal were fruitless. I. barbarabrownae belongs to a family of rodents known as "spiny rats" because most of the species in that family bristle with spines. Its discovery has necessitated a re-examination of this tropica...New nanotechnology able to examine single molecules, aiding in determining gene expression
...ad author. "Scientists have been hampered in their efforts to unlock the secrets of gene transcription in individual cells by the minute amount of material that must be analyzed. Nanotechnology allows us to push down to the level of individual transcript molecules." "We are likely to see more of these ki...US conservation efforts bring more marine turtles to UK
US and Mexican conservation efforts may have boosted the number of marine turtles visi...w see the positive effect that recent conservation efforts have had on these turtle species.? A large majority of marine turtles that visit Northern European...Cells selectively absorb short nanotubes
..., health and safety impacts of SWCNTs could derail efforts to fast track the development of nanotubes for advanced technology applications. A significant hurdle in outlining the parameters contributing to nanotube toxicity is to prepare well-defined and characterized nanotube samples, as they typically conta...Faster, low cost sequencing technologies needed to drive era of personalized medicine
...nstitute at Arizona State University are expanding efforts to dramatically lower the cost of DNA sequencing. The NHGRI, part of the National Institutes of Health (NIH), has set an ambitious target of $1,000 or less - a cost 10,000 times lower than current technology - to make genome sequencing a routin...NASA snow data helps maintain nation's largest, oldest bison herd
... actually a sign of how successful our restoration efforts have been," said Rick Wallen, leader of the Park's Bison Ecology and Management team. "The modeling of snowpack conditions on winter ranges provides managers a measure of how quickly a snow-covered area becomes clear during the spring melting period....New study aims to stop sepsis in its tracks
...zed protocols for what to do right away, and their efforts improve your odds for a full recovery. That's not the case if you have a body-wide infection known as sepsis, which can be fatal within a few hours and is often not diagnosed until it is too late. Now, a new, multicenter research consortium, called...One-of-a-kind imaging probe reveals secrets useful for drug discovery
...n from very tiny samples, which could be useful in efforts to understand Alzheimer's disease and other disorders. "There are many potent, useful molecules made by plants and animals, but they are usually produced in such small quantities it takes a huge amount of material to characterize them," said Arthur ...