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Tag: "efficiently" at biology news

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

... becausephotolyases ?a class of enzymes capable of efficiently repairing theselesions ?have apparently been lost from placental mammals over thecourse of evolution.Thus, most mammals, including humans, can only repair these lesionsthrough a much less direct and elaborate process called nucleotideexcision repair....

NIAID Initiates Trial of Experimental Avian Flu Vaccine

...rned that the virus will develop the capability of efficiently spreading from human to human and thus create a risk for a worldwide pandemic,?says NIAID Director Anthony S. Fauci, M.D. “NIAID has supported research on H5N1, the strain responsible for this deadly form of avian influenza, since 1997 when the firs...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

... very clear targeting. Our results show that we've efficiently ablated (destroyed) the ability of the measles virus to interact with its two natural receptors. And they also show that we can take our pick as to what new receptor we target and send the virus after it." How They Did It Using bioengineering techn...

NIH Calls on Scientists to Speed Public Release of Research Publications

...s that NIH and its awardees can use to manage more efficiently and to understand better their research portfolios, monitor scientific productivity, and, ultimately, help set research priorities; and 3. making published results of NIH-funded research more readily accessible to the public, health care provider...

Glow-in-the-dark zebrafish at UH hold keys to biological clocks

...usand odds of finding a mutant are more easily and efficiently attainable," Cahill said. "Ultimately, this type of research can help with tracing why humans develop such things as sleep disorders or mental illnesses like depression." Per3 is the naturally occurring clock-regulated gene. The protein that it enco...

Newly discovered pathway might help in design of cancer drugs

... step further, establishing that there is a way to efficiently create this type of damage by modifying the DNA itself." In the lab, Greenberg and his team used organic chemistry to create a synthetic, double-stranded DNA with special chemical characteristics and exposed it to long wavelength light that selectiv...

New understanding of DNA repair may pave way to cancer treatments

... small peptide that interferes with ATF2 function, efficiently blocking melanoma growth in mouse models. Ongoing studies are devoted to screening for compounds that mimic the peptide's actions and to allow for further development of the peptide toward clinical assessment. "Until our recent studies, we were cert...

Gladstone investigators discover how resting T cells avoid HIV infection

...rge form in activated CD4 T cells, where the virus efficiently grows and wreaks havoc. They further showed that blocking production of the small, active form of A3G in resting CD4 T cells was sufficient to make these normally resistant resting cells highly susceptible to HIV infection. "Until now, the prevailin...

Scientists generate patient-specific stem cells, Science study says

.... In addition, researchers must develop methods to efficiently direct the differentiation of embryonic stem cells...ers generated these stem cell lines ten times more efficiently than in their 2004 Science study, using improved laboratory methods. The single cell line generated...

SuperLigands - a database of ligand structures derived from the Protein Data Bank

.... In addition, researchers must develop methods to efficiently direct the differentiation of embryonic stem cells...ers generated these stem cell lines ten times more efficiently than in their 2004 Science study, using improved laboratory methods. The single cell line generated...

Gene silencing technique offers new strategy for treating, curing disease

...gy, Dr. Corey and his colleagues describe how they efficiently shut down gene expression in cultured cells by blocking the ability of chromosomal DNA to be copied into RNA and made into proteins. The studies, which Dr. Corey said represent the most significant findings thus far in his career, are the most defini...

Researchers discover mechanism for multiplying adult stem cells

...ransplantation. If so, it may help scientists more efficiently "customize" embryonic stem cells that could be used to treat diseases such as diabetes or Parkinson's. ...

Insects develop resistance to engineered crops

...aining two insecticidal proteins in a single plant efficiently kill insects. But when crops engineered with just one of those toxins grow nearby, insects may more rapidly develop resistance to all the insect-killing plants, report Cornell University researchers. A soil bacterium called Bacillus thuringiensis (B...

Study shows how retinoic acid enters a cell's nucleus

...dramatically. The protein transfers RA rapidly and efficiently to the cell's nucleus. In this way, tumor growth may be inhibited using naturally occurring levels of RA, as opposed to the toxic doses currently administered. "If you can provide a bus to get retinoic acid into the nucleus more efficiently, then yo...

Pinpointing a culprit molecule in Alzheimer's disease

...settled this question, because the peptide was not efficiently secreted by the cells in those mice. However, wrot...ct from these other "minigene" models in that they efficiently secrete Ab. To date we have little evidence for the accumulation of intracellular Ab in these mice; ...

Microreactor efficiently regenerates cofactors for biocatalysis

...oulouse, France, has developed a microreactor that efficiently regenerates cofactors through enzyme-catalyzed reactions. "Enzymes are nature's catalysts, but in some cases, enzymes can not prompt a speedy chemical reaction," said Paul Kenis, a professor of chemical and biomolecular engineering at Illinois and a...

Gene therapy advance treats hemophilia in mouse models

...ats but no disease in humans. The hybrid vehicle efficiently bound to receptors on the liver cells because the modified baculovirus coat serves as a "key" that fits into the "lock," or receptor. The percentage of liver cells that took up the virus increased from approximately 5 percent to 20 percent. The tea...

MSU researchers receive $4 million grant to uncover gene functions

...lant biology at MSU. "We also will be able to more efficiently make nutrients important to human health. These include vitamins and heart-healthy oils." The NSF's Arabidopsis 2010 project is a worldwide effort to catalogue the function of every gene in the plant - something never before accomplished with any pl...

Microbe has huge role in ocean life, carbon cycle

...te set of biosynthetic pathways, and can reproduce efficiently by consuming dissolved organic matter. "By comparison, humans are mostly junk DNA, with large parts of the human genome having no important function," Giovannoni said. This type of genome streamlining, researchers say, appears to be a major factor ...

Sleeping beauty plays a significant role in identifying cancer genes

...ontained Sleeping Beauty, researchers were able to efficiently find genes linked to cancer by seeing whether Sleeping Beauty turned them on or off -- in effect, uncovering the fingerprint of each tumor's cancer genes. David Largaespada, Ph.D., associate professor and leader of the Genetic Mechanisms of Cancer P...

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