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Tag: "effectively" at biology news

In a technical tour de force, Salk scientists take a global view of the epigenome

...ith proteins required to activate gene expression, effectively silencing the methylated gene. Ecker and Jacobsen were funded by the National Human Genome Research Institute (NHGRI), which launched a public consortium known as ENCODE, for the Encyclopedia Of DNA Elements. Now that the human genome has been seq...

Attacking cancer's sweet tooth is effective strategy against tumors

... in a variety of fast-growing breast cancer cells, effectively shutting down glycolysis, and implanted the cells in mice. Control animals carrying tumor cells with an intact glycolytic pathway did not survive beyond 10 weeks. In striking contrast, only two of the LDHA-deficient mice died, one at 16 weeks, anothe...

Cincinnati surgeons report new treatment for often-fatal injury

... of small synthetic grafts (endografts) they could effectively protect the damaged area without stopping blood flow to the rest of the body. The endografts are regularly used in vascular surgery to treat aneurysms in the abdomen, Dr. Giglia explains, but they are too short to fully bridge the damaged area in t...

Johns Hopkins lab scientists tame overactive CF protein

... protein and prevented cell damage by the protein, effectively restoring the cell to normal. "The hope is that these findings will be used to design therapies and drugs that go beyond symptom management and actually restore normal cell function to prevent CF," says senior investigator Pamela Zeitlin, M.D., a pu...

Genomatix technology facilitates de novo identification of new renal disease associated genes

...rated. Genome-wide scans using this promoter model effectively predicted a previously unrecognized slit diaphragm molecule which was then experimentally verified. This publication shows a straightforward approach how comparative promoter analysis can identify regulatory pathways at work in tissue homeostasis a...

Mystery solved: Gold's power against autoimmune diseases defined

... a German doctor named Robert Koch found that gold effectively killed the bacteria that caused tuberculosis. In the 1930s, based on a widely held but probably erroneous connection at the time between tuberculosis and rheumatoid arthritis, a French doctor, Jacques Forestier, developed the use of gold drugs for th...

Alaska seal pup diet may hold key to decline of population

...seals, she said. After weaning, pups must learn to effectively fish and accumulate sufficient fat stores for the winter, but changes observed in the distribution, composition or abundance of fish may make it harder to ingest and store enough fat. The study aimed to find out what effect the fat content of the har...

p53, tumor suppression and aging

...nd that even a modest decrease (about 20%) in Mdm2 effectively prevents tumor formation and does not lead to premature aging. Dr. Perry emphasizes that "many people develop cancer at a young age due to increased expression of Mdm2. The possibility that inhibitors of Mdm2 could delay cancer in such people witho...

Wisconsin scientists grow two new stem cell lines in animal cell-free culture

...product in stem cell culture systems. The new work effectively removes remaining animal products such as bovine s...nology report conclude. While the 2001 compromise effectively opened up the field of embryonic stem cell research in the United States, researchers have been call...

Possible brain hormone may unlock mystery of hibernation

...ists have suggested that hibernation therapy might effectively preserve donor organs for weeks or months. Hibernation has also been found to protect animals from a wide range of potential threats, from muscle disuse to cancer, the study authors said. Therefore, hibernation therapy might confer protective effect...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

...resistance to cisplatin by altering its ability to effectively kill tumor cells. By understanding the features of cisplatin that contribute to resistance, Farrell and his team designed the new compound to circumvent these problems. ...

HIV vaccine takes different tack to boosting immune response

...ntiretroviral treatment, HIV could be treated more effectively or prevented altogether. "A lot of vaccines work very well in dealing with some pathogens, but for HIV, the natural immune response usually fails," said Dr. Si-Yi Chen, associate professor at the Center for Cell and Gene Therapy at BCM and senior au...

One fish, two fish: New MIT sensor improves fish counts

...ul information with signals far less intense. This effectively "illuminates" vast areas of the ocean, about a million times larger than what could previously be studied. The images can be updated every minute, offering a chance to continuously monitor the shoals as they change in size and shape over time. The n...

Scientists discover new genetic subtypes of common blood cancer

...have different prognoses and might be treated most effectively with drugs specifically targeted to those subtypes. A new computational tool based on an algorithm designed to recognize human faces plucked the four distinguishing gene patterns out of a landscape of many DNA alterations in the myeloma genome, the ...

Heparin prepared synthetically could replace animal-derived drug

...ic Institute. "These discoveries will enable us to effectively replace a variable raw material ?heparin derived from processed animal organs ?with a synthetic material ?synthetic heparin ?and have the same therapeutic result." Research in Linhardt's group at the Center for Biotechnology and Interdisciplinary S...

Berkeley researchers lay groundwork for cell version of DNA chip

... possible coding options," said Chandra. "The DNA effectively serves as a molecular barcode on the surface of living cells." Whereas the mounting of single-stranded DNA on the surface of a chip and using it as a probe to identify genetic matches is a well-established technology, this is the first time that sin...

New study reveals promising osteoporosis treatment

...bisphosphonate drugs and hormone therapies, do not effectively repair bone that has already been lost. In fact, bisphosphonates have been shown to actually inhibit bone redevelopment. Many of these treatments also have serious side effects, including increasing the risk of heart disease, strokes, and breast can...

New insight into machinery of immune cells' 'tentacles'

...for drugs to induce the immune system to work more effectively to fight infection; or to damp its stimulation in ...ation" between T and B cells enables the T cell to effectively identify and target such invaders for destruction. The site of contact between the T and B cells has...

Two NIH initiatives launch intensive efforts to find roots of common diseases

... either prevent illness from occurring or treat it effectively once it does." There are about 10 million common SNPs in the human population. Scanning the genomes of large numbers of patients for such a large number of variants would be prohibitively expensive. Fortunately, a major shortcut has been discovered...

Report finds cruise industry is protecting the precious places it visits

...ific recommendations for how these groups can more effectively work together to manage increased cruise passenger visits while minimizing negative environmental, cultural and societal impacts. Examples of these recommendations include: Cruise Lines: Cruise lines should work with local governments and commu...

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