Novel pathway regulates timing of brain cell development
...o, in part, with its effects on erbB4 activity--an effect that was previously unrecognized. ErbB4 signaling also regulates neuronal function and survival, processes that have been implicated in Alzheimer's pathology, the researchers note. "Our findings raise the intriguing possibility that defects in pres...To slow AIDS in Russia, treat HIV-positive addicts, Stanford study says
...amount of virus in a person's body. The cumulative effect of two or three medicines works better than a single one to keep the virus at bay. Antiretroviral therapies have the added benefit of reducing the chances that an infected person will transmit HIV to others. To understand how antiretroviral ther...LSD treatment for alcoholism gets new look
...he results of the study, but wanted to observe the effect of LSD on the patients in isolation, so they blindfolded or tied up the patients before giving them the drug. Under such circumstances, the Toronto researchers determined LSD was not effective in treating alcoholism. The Saskatchewan group argued ...Cocaine high caused by interference in neuronal receiving stations
...ocaine. In studies with rats, they have traced the effect to interactions between two types of receiving sta...of the D2R-NR2B interaction in mediating cocaine's effect on [kinase binding and phosphorylation] and in constructing a full-scale motor response to cocaine,"...'GreeneChip' -- New diagnostic tool that rapidly and accurately identifies multiple pathogens
...ia and early, specific therapy can have a profound effect on illness and death. The GreeneChip provides unprecedented opportunities for unbiased pathogen discovery and reduction of illness and death caused by infectious disease....New technology to speed up research into Huntington's disease
...erformance that the mice cannot deliver due to the effect of the disease on their motor abilities. The automated screen developed by Cambridge scientists provides a simple means of assessing cognition, in a way that requires minimal movement on the part of the mouse. The mouse makes its response by touc...Elusive rust resistance genes located
... track Lr34 / Yr18 in wheat because of the masking effect of other resistance genes," Dr Lagudah says. "In addition, tests for Lr34 / Yr18 were slow and could only be done once per season and on adult plants growing in the paddock. "Using the marker technology breeders can now quickly and easily tes......ic GMP, and it may be possible to achieve the same effect by using drugs that block cyclic GMP's breakdown, Rosenberg says. One surprise in the research was that the main message telling the brain to go to sleep probably does not come from neurons, but from neighboring glial cells, which appear to produc......le cell patch clamp used to measure any electrical effect on the nerve cells. When a lateral voltage is appl...passed across the film to the nerve cells. The net effect is a kind of reverse amplification of the applied voltage that stimulates the nerve cells without da...Rescuing injured hearts by enhancing regeneration
...y and oxygen to survive. FGF1 did not have a great effect on cell proliferation, but we found it was providing a new blood supply. If you just inhibit p38 MAP kinase, you don't get blood vessels." Two important steps are needed to turn these findings into a treatment, Engel says. First is to show that t...Carnegie Mellon scientists use 'green' approach to transform plastics manufacturing
...y, researchers add more CuI to compensate for this effect and maintain the balance between the two copper species. But this approach ultimately generates materials with high overall levels of copper -- levels that are too costly to remove efficiently on a large-scale industrial basis. The PNAS report hig...Study illuminates how the plague bacteria causes disease
...said. "The GDI domain seems to have an even bigger effect on host cells in culture, and a significant impact on virulence." The results also add to broader themes in the evolution of bacterial diseases, the researchers added. "It is becoming increasingly clear that a common strategy used by bacterial pat...Study IDs protein that inhibits HIV from growing in cell cultures
...eed to zero in to see what region has the critical effect on HIV inhibition." Once that is accomplished, the team will seek to develop small molecular drugs that mimic the inhibiting action. Stapleton noted that GBV-C is not toxic to T-cells and is not associated with any human disease. As a result, t...New sunscreen ingredient to heal sunburn and help prevent skin cancer
...n out of cells, but that would not have an adverse effect on other essential cellular processes. After th...fter 3pm. "UVA was once thought to have a minor effect on skin damage, but now it is considered to be a major contributor as it penetrates deeper into the ...From hot springs to rice farms, scientists reveal new insights into the secret lives of archaea
...ds Hole Oceanographic Institution will discuss the effect of temperature and chemistry on archaeal communities inhabiting marine hydrothermal vents on the island of Vulcano, Italy. Several species of thermophilic archaea live in these shallow waters, where temperatures sometimes approach the boiling point. ...Drug can quickly mobilize an army of cells to repair injury
...ished in a recent issue of Blood, which tested the effect of both AMD3100 and G-CSF in mice after blood flow to a leg had been impaired. Both drugs induced new blood vessels to grow in the affected legs of the mice, and combining the drugs had the greatest benefit. "We are now working to set up a clinical ...Regulating the nuclear architecture of the cell
...binds methylated H3K9 and Su(var)3-9 proteins; the effect is to further close up the chromatin, silencing ge...H3 histone's fourth amino acid, also a lysine. The effect is to open the chromatin at that site, making the DNA accessible. "Acetylating H3K4 and demethyl......ty to pain," McIntosh says. Vc1.1 had a similar effect ?replicating studies by other researchers ?allowing rats with sciatica to tolerate touch with greater pressure. The new study is not McIntosh's first involving chronic pain. As an incoming college freshman working in Olivera's lab in 1979, McIntos...Bad blood between boys and girls
...urnal Naturwissenschaften this week, to suggest an effect of parasitic infection on the sex of a baby. Kankova and colleagues analysed the effect of latent (or dormant) toxoplasmosis on the probability of the birth of a boy in humans. Latent tox...Biodegradable napkin -- featuring sensitive nanofibers -- may quickly detect biohazards
... would signal by changing color or through another effect when the antibodies attached to their targets. Users would simply wipe the napkin across a surface; if a biohazard were detected, the surface could be disinfected and retested with another napkin to be sure it was no longer contaminated. In work con...