New method enables gene disruption in destructive fungal pathogen
...ntibiotic-resistance marker gene, which allows for easy selection of the new mutants, as well as a short partial target gene that integrates and disrupts genes in the pathogen's genome. Richard Oliver, director of the Australian Centre for Necrotrophic Fungal Pathogens and professor of Molecular Plant P...Virginia Bioinformatics Institutes launches microbial database
...ct's researchers created a browser, which makes it easy for users to view the genome sequence data and connect to detailed annotation pages for each sequence. The community annotation interface is available for registered members to add or edit annotations. The database will be expanded in 2006 to inclu...U-M researchers take new approach to defeating Gram-negative bugs
...ie, they were weakened, and that made the cells an easy target for antibiotics. Because Woodard suspected he might be flying in the face of conventional wisdom on bacteria, he solicited second opinions from the Borstel Research Center in Germany, which does a good deal of work on Gram-negative bacteria. ...Molecular mechanism may explain how fevers spark seizures
...e window and counting the cars on the street: it's easy to count how many are there at any time, but if we want to know where they all came from and where they're all going, that's a whole different problem." The team's discovery that high temperature reduces cell surface GABA-A receptor levels "raises ...New test to detect rare proteins in blood
...ases, and possibly psychiatric diseases relatively easy and more accurate compared with the current methodology, including the widely used ELISA (enzyme-linked immunoadsorbent assay). ELISA is a common immune-system-based assay that uses enzymes linked to an antibody or antigen as a marker for picking o...How can we protect patients with weakened immune systems from influenza?
...rror weapon, the influenza virus may be relatively easy to manipulate for such purposes in a laboratory ?which is why the federal government is funding medical research to improve defenses against flu. Dr. Sullivan looks to broader and longer-term benefits of her funded program. "Even if the worst-case s...Lack of basic research putting patients at risk
...suffered as a result, yet much of this research is easy and relatively cheap to do, so why has it not been done, he asks? He calls into question whether medical academia, in its current form, is properly fit for purpose. He believes that medical academia must improve its performance or, less preferably,...Georgia Tech accelerates drug discovery with new IBM supercomputing cluster
...d and tested super-cluster that is ultra-dense and easy to manage. "AMD64 technology delivers the processing power needed to run some of the most demanding supercomputers, without sacrificing performance-per-watt efficiencies," said Kevin Knox, vice president, Worldwide Commercial Business, AMD. "By wor...Multi-million pound UK Biobank underway
...g into the evenings and at weekends, so that it is easy for lots of different people to attend. "UK Biobank is a long-term project," said Professor Collins, "so taking part will be a bit like being a blood donor ?you probably won't benefit, but others will. In this case it will be your children and grand...Common enzyme is a key player in DNA repair
...nto an ordinary polymerase. When a protein is that easy to modify, scientists assume its function must be important to have survived several billion years of evolution. "In general, we think that nature evolved this function to help us survive DNA damage that would otherwise kill us," said Walker. "It's...Neuroscientists discover new cell type that may help brain maintain memories of smells
...as it coursed through the brain, it was relatively easy to see where it ended and where I should look for potential target cells. Because I knew where to look, this part of the project was shortened from potentially years to just a matter of weeks", said Pressler. The multiphoton microscope used in thi...Animal brains 'hard-wired' to recognize predator's foot movements, Queen's study suggests
...s nearby. "The observation that it is relatively easy to get close to wild animals in a car, a canoe, or a similar vehicle might be due to the absence of the typical movement of the feet," says Dr. Troje. Similarly, the creeping movement of a hunting cat can be interpreted in terms of disguising the bal...Scientists discover basic defect in cystic fibrosis airway glands
...n the lungs and blocks the airways. This makes it easy for bacteria to grow and leads to repeated serious lung infections. The thick, sticky mucus can also block tubes in the pancreas, preventing digestive enzymes from reaching the small intestine. The disorder results from mutations in the gene for th...Researchers develop portable 'vein finder' for faster, more accurate injections
...ou locate a vein at the skin's surface, it's still easy to miss when you try to insert a needle into the tissue below." The Doppler effect is a phenomenon that occurs when electromagnetic and sound waves interact with a moving object, altering wavelengths and frequency. For example, a police radar gun s...Stem cell study for patients with heart attack damage seeks to regenerate heart muscle
...rgical procedures, but this one is very simple and easy for the patient. "A person who has had a single, severe heart attack may survive but can be left with substantial damage to the heart muscle as a result of the blood supply to the heart muscle being cut off during the heart attack. The damaged musc...Newly discovered protein kills anthrax bacteria by exploding their cell walls
...y A biological agents being the scariest: They are easy to spread, kill effectively and call for special a...icient biowarfare agent. Its spores are stable and easy to produce, and once someone inhales them, there is only a 48-hour window when antibiotics can be us...Lack of a key enzyme dramatically increases resistance to sepsis
...on that allowed a gradual occurrence of sepsis and easy identification." A majority of mice with caspace-12 died from sepsis within the first 48 hours after onset, while 60 percent of the caspase-12 deficient mice survived. The deficient mice also showed a significantly lower number of bacterial colony-f...Natural selection at single gene demonstrated
...eed to be revisited because the model makes it too easy to infer selection at any given gene. "Once you start looking at enough cases then you realize that, oops, it's all under selection. I think a lot of that research is going to end up in the trash can," Nordborg said. The group's method can be appl...Human albumin from tobacco plants
...mass in tobacco plants The tobacco plant is very easy to handle genetically and also it is great generator of biomass. The authoress of the thesis says that up to 100 tons of biomass per hectare can be obtained in optimum growth conditions. "Given that the protein is produced in the chloroplasts, the mo......nalyses, making secondary metabolite gene clusters easy to spot. Keller capitalized on these facts to find actively-produced secondary metabolites. In one experiment, Jin Woo Bok, a research scientist in Keller's lab and co-author on the paper, deleted the LaeA gene in Aspergillus nidulans. Using a d...