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Tag: "dystrophy" at biology news

Switching genes to overdrive improves muscular dystrophy symptoms in mice

... of Iowa College of Medicine. Duchenne muscular dystrophy (DMD) is the most common type of muscular dystrophy in children, occurring once in about every 5,000 live births of boys, and is ultimately fatal. The a...

The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better

...ab while searching for a cure for Duchene muscular dystrophy (DMD). DMD is a genetic disease estimated to affect one in every 3,500 boys. Patients with DMD lack dystrophin, a protein that gives muscle cells structure. Using an animal model of the disease, his laboratory is using stem cells to deliver dystrophi...

Scientists show drug can counteract muscular dystrophy in mice

...nzyme deacetylase, in two mouse models of muscular dystrophy (MD): one that naturally develops a disease similar to Duchenne muscular dystrophy in humans, the other genetically altered to develop a form of dystrophy similar to the human limb-gi...

Leading reason for corneal transplants comes into focus

...rcent of the population over 40. Late in life, the dystrophy causes swelling of the cornea and can severely aff...x years ago when he treated a woman with a corneal dystrophy of unknown origin that looked remarkably similar to FCD despite slightly different symptoms. "I knew...

Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy

... weakness and fiber deterioration seen in muscular dystrophy can be countered by a class of drugs currently und...hich muscle function declines in Duchenne muscular dystrophy and related dystrophies. Indeed, muscles examined from dystrophic mice treated with Trichostatin A ...

A giant among minnows: Giant danio can keep growing

...already shown that a condition similar to muscular dystrophy can be experimentally induced in zebrafish. One of...he giant danio will be able to handle the muscular dystrophy better because of their ability to increase muscle,?Biga said. What makes this intriguing is that hu...

'Smart' genetic therapy helps the body to heal itself

... a promising genetic therapy for Duchenne muscular dystrophy (DMD). Using anti-sense molecules (small pieces ...d by animal work. The team has used the muscular dystrophy mouse model to study optimal dose regimes, and further study exon skipping levels. This study foun...

FSU biologists uncover mechanisms that shape cells for better or worse

...in fruit fly eggs may help to clarify how muscular dystrophy and some cancers develop in humans. That's because many of the genes involved in the cell-to-cell communication that triggers the development of cell polarity in Drosophila oocytes (unfertilized fruit fly eggs) also are known players in the pathoge...

Toxic molecule may cause most common type of muscular dystrophy

...otonic dystrophy, the most common type of muscular dystrophy in adults. About 40,000 people in the United States have myotonic muscular dystrophy (MMD). The disease can cause a slow, progressive wasting of the muscles, irregular heartbeat, catara...

UF scientists test improved gene therapy method for hereditary heart conditions

...y reverse symptoms in mice with a form of muscular dystrophy that damages the heart. They also tested the virus...tients with Pompe disease, a rare form of muscular dystrophy that is usually fatal in the first year of life. "Nine years ago we knew we could get long-term ge...

Mouse study: New muscle-building agent beats all previous ones

...ce than a related potential treatment for muscular dystrophy now in clinical trials. The new agent is a versio... muscles are wasting due to diseases like muscular dystrophy or side effects from cancer treatment or AIDS. "This new inhibitor of myostatin, known as ACVR2B, ...

New neurons take baby steps in the adult brain

...ling nerves that succumb in diseases like muscular dystrophy and amyotrophic lateral sclerosis, or nerves that are damaged by trauma or injury. In none of these systems are new neurons formed or integrated to any great extent naturally. ...

Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds

...the disease. Using gene therapy to treat muscular dystrophy isn't a new idea. Thomas Rando, MD, PhD, associate...o repair the entire muscle cell. Previous muscular dystrophy gene therapy studies did not look at whether the introduced dystrophin spread along the entire lengt...

Cornell finds natural selection in humans

... negative selection are those involved in muscular dystrophy and in Usher syndrome, the most common cause of congenital blindness and deafness in developed countries. "We have a long way to go before we can predict from looking at sequences, which mutations in which genes and under which environmental conditi...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

... tested AAV-8 in an animal model of human muscular dystrophy called limb girdle muscular dystrophy, or LGMD. In...f heart failure or other complications of muscular dystrophy around 37 weeks, while all of the AAV-8-treated LGMD hamsters survived beyond the 48-week duration o...

Research casts doubt on circulating stem cells

...issue. Even severe diseases like Duchenne muscular dystrophy (DMD), which destroys all the body's muscles, appeared to be potentially treatable ?indeed, by the simple means of transplanting healthy bone marrow. For boys, DMD is the second most common hereditary disease. Due to a genetic defect, the muscles fai...

No small feat: First ever gene therapy success for muscular dystrophy achieved

...e therapy for the treatment of congenital muscular dystrophy (CMD) in mice, demonstrating that the formidable s...apy ever being feasible for children with muscular dystrophy can be overcome. Moreover, their results, published in this week's online edition of the Proceedings...

Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

...ac muscle, too. Many people with Duchenne muscular dystrophy die in their 20s from heart failure caused by cardiomyopathy, a gradual weakening of the heart muscle. Heart failure is the second leading cause of death in DMD. The chemical sealant that protected hearts in dystrophic mice from damage is called pol...

Scientists analyze chromosomes 2 and 4

...ase, polycystic kidney disease, a form of muscular dystrophy and a variety of other inherited disorders. Chromosome 2 is noteworthy for being the second largest human chromosome, trailing only chromosome 1 in size. It is also home to the gene with the longest known, protein-coding sequence ?a 280,000 base pair...

GenMAPP 2.0 released

...a, colon cancer, congenitalheart defects, muscular dystrophy and other birth defects....

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