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Tag: "dysfunction" at biology news

Proteasome activator enhances survival of Huntington's disease neuronal model cells

...regates of mutant huntingtin in HD brains indicate dysfunction of the UPS. From these results, we hypothesized that enhancing UPS function would improve catalytic degradation of abnormal proteins in HD. We first genetically engineered proteasome activators involved in either non-ubiquitinated protein degradation...

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