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Tag: "drug" at biology news

Protein therapy may reduce infarct size in heart attack patients

.... This first-in-human study suggests that this new drug may have promise as a potential therapeutic agent ...ceive intracoronary injections of the active study drug (KAI-9803) vs. placebo in four dose groups (0.05, 0.5, 1.25 or 5.0 mg of KAI-9803). Researchers per...

Cellulose nanocrystal research could lead to new vaccines, computer inks

...29. The focus of her research deals with cellulose drug delivery and ink jet printing. Roman experimented with taking cellulose nanocrystals and attaching antibodies to the surface of the crystals. This design enables the nanocrystals to block cell receptors in the body. The process may eventually be u...

Turning a cellular sentinel into a cancer killer

...These mice were genetically engineered so that the drug tamoxifen could be used to switch on p53 activity....portant drivers of tumorigenesis, making them good drug targets," he said. "For these, we could do the converse experiment, letting the tumor develop and th...

Anti-fungal drug stops blood vessel growth

...s Hopkins have discovered to their surprise that a drug commonly used to treat toenail fungus can also blo...gy. “We couldn’t have predicted that an antifungal drug would have such a role.? In their search for antiangiogenesis drugs, the researchers worked with c...

The influence of the menstrual cycle on the female brain

...or example, female rats self-administer cocaine (a drug that acts on the dopamine system) in higher doses ...kinson's disease, schizophrenia, normal ageing and drug and gambling addictions. ...

A first glimpse of the influenza replication machine

...ll explore both structure and function of this key drug target and try to characterise other mutations implicated in bird-to-human transmission." ...

Creating new life forms that may help eradicate cancer affecting women

...ry, chemotherapy, or radiation, researchers from a drug development company called Advaxis, have embarked on a novel approach to fighting cancer: Engaging the immune system to attack cancer in the same the way it would a flu vaccine, by creating new life forms. Dr. Vafa Shahabi, Advaxis' Director of Res...

Smokers quit after damage to brain region

... study of its kind to use brain lesions to study a drug addiction in humans," Naqvi said. In the 1990s, Antonio Damasio proposed the insula, a small island enclosed by the cerebral cortex, as a "platform for feelings and emotion." The Science study shows that the pleasure of smoking appears to rest on t...

Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows

A once-a-day, short-term treatment with a drug compound substantially improved learning and memor... wild-type counterparts for up to two months after drug treatment was discontinued. "Somehow the drug treatment creates a new capacity for learning," sai...

Syphilis rate on rise in US gay, bisexual men

...be going up for several reasons, including illicit drug use and "safe-sex fatigue." In addition, he said, prevention messages might have been "drowned out" by talk about how medications are doing a great job of keeping AIDS patients alive. "We’ve been seduced by these amazing drugs and we’ve fallen beh...

Coated nanoparticles solve sticky drug-delivery problem

...d further tests to see how large their microscopic drug carriers could be before they got trapped in the m...eeks. Larger particles also allow a wider array of drug molecules to be efficiently encapsulated. He and his colleagues believe this system has great potent...

New test helps identify hepatitis C patients at high risk of developing cirrhosis

...d toward a long course of expensive, debilitating drug therapy, while low-risk patients might be better ...kly injections of alpha interferon along with the drug ribavirin, which can cost more than $30,000 per year and can cause flu-like symptoms, nausea, depre...

New insights into autoimmunity and depression

...mice were treated with haloperidol, a psychotropic drug used to treat anxiety, addiction, and depression. To determine the effectiveness of each therapy, mice were subjected to repeating the forced swimming, staircase, and rotarod tests. Depression-like behavior was significantly blocked by long-term trea...

Groundbreaking Canadian asthma study

...ts who have asthma symptoms despite use of current drug therapies." Bronchial thermoplasty is a minimally invasive procedure that reduces the amount of airway smooth muscle that is responsible for the constriction of airways in asthma patients. Using a flexible bronchoscope through the nose or the mou...

Clues to gene expression in cystic fibrosis will guide research

...piration. Gentamicin itself may not be an ideal drug option, as it may cause serious side effects for some patients, including ear and kidney damage. The authors suggest that other drugs, such as amikacin or PTC124, with a comparable mode of action and fewer side effects, may have treatment potential. ...

Novel laboratory technique nudges genes into activity

...ight be able to exploit the process to develop new drug targets, Dr. Corey said. For example, current methods to block gene expression, such as RNA interference, rely on using RNA strands to intercept and bind with messenger RNA. While RNA interference is an effective tool for studying gene expression,...

'Exercise pill' switches on gene that tells cells to burn fat

By giving ordinary adult mice a drug - a synthetic designed to mimic fat - Salk Institu...sed endurance. Adult normal mice that receive the drug to switch on PPAR-d show increased fat burning and resistance to weight gain, but they do not show i...

Cholera pathogen reveals how bacteria generate energy to live

...be targeted by novel antibiotics. "An inhibitor or drug would be specific," she said. "You could kill the bacteria without doing anything to the human host." But Barquera believes that the most important benefits of her research could develop in ways that cannot be foreseen: "From the basic science po...

Cancer cells forming blood vessels send their copper to the edge

...per from the body can help stop angiogenesis. If a drug can be used to intercept vital copper being translocated outside of the cell during angiogenesis, the process stops, preventing growth of the tumor." The implications of the research do not end with the effect on angiogenesis. The dynamics of cell...

HIV dementia alarmingly high in Africa

...retroviral medication, thus increasing the risk of drug resistance. People with dementia also are less likely to practice safe sex. Before antiretroviral medications were available in the United States, the U.S. rate of HIV dementia was similar to what was discovered in this study in Uganda, says Sackt...

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