Risk of lymphoma increases with hepatitis C virus infection
...ic status, and particularly a history of injection drug use or blood transfusions received before 1990, when screening for hepatitis C virus was started. ...Molecule that destroys bone also protects it, new research shows
...ting IL-17 too much could put people taking such a drug at risk for opportunistic infections such as periodontal disease and tuberculosis, she noted. "Developing knowledge about the molecules that contribute to host defense versus pathology is very important for gaining a fundamental understanding of ...Warts vaccine -- 1 of many in pipeline
...ering for medical discoveries, clinical trials and drug manufacture. "Conducting trials in Australia gives Australians the chance to help develop new treatments," Professor Frazer said. "Should the product under trial be effective, it also gives them the chance to be amongst the first to benefit." ...Dealing deadly cancers a knockout punch
...ce reported on the use of Reolysin plus the cancer drug cyclophosphamide in an animal model of melanoma. When treated with both agents, test animals experienced enhanced tumor regression compared with either agent alone, and without additional toxicity. Oncolytics has permission from the U.K. regulatory a......ility of less drastic treatment options, including drug interventions," said Solaro, who is also director ... the heartbeat may offer new avenues of diagnosis, drug design and treatment of many common heart diseases," said Solaro. "Further, now that we know some...DNA-damage test could aid drug development
...marathon that leads to successful drugs, promising drug candidates must pass toxicity tests before enterin...genetic toxicity to be examined far earlier in the drug development process, making it much more efficient. Like the current FDA-approved test, the new tes...Chemical maps hint at drug's effects on schizophrenia
...ations, the signatures differed according to which drug was used, giving researchers a tool to explore the metabolic side effects of these and other drugs. The team's findings also appear in the May 2007 issue of the journal Molecular Psychiatry. The work was funded by the Stanley Medical Research Inst...Executable biology -- Computer science sheds light on animal development
... how the system responds to a variation ?such as a drug or a genetic mutation. Preliminary studies could be quickly done using the model, saving valuable laboratory time and resources for only the most promising research avenues. We call this Executable Biology."...Revealing the machinery underlying the 'plastic' juvenile brain
...ffected plasticity, the researchers administered a drug to adult mice that would increase chemical modification of histone. They found that such adult mice, indeed, showed an increase in a form of visual plasticity. "Our results show that visual experience differently activates intracellular signaling ...Biodegradable microspheres deliver time release vaccines, stimulate different immune response
...being used as a delivery system for a brain cancer drug designed to inhibit tumor growth. "It's like an Everlasting Gobstopper or a bar of soap. It wears away slowly over time, delivering its payload," says Wilson-Welder. The researchers vaccinated mice with microspheres loaded with ovalbumin, a pr...Individuals and populations differ in gene activity levels, not just genes
...of Human Genetics. "This is exactly what makes drug development so difficult, or why it's so hard to pinpoint an exact cause for a particular disease," said Akey. "People have so much variation both in their genetic information and in how those genes are activated and regulated. We need to have a much...Leukemia drug turns mini-molecules up, cancer genes down
...for cancer development, helping to explain how the drug works. The drug is called all-trans-retinoic acid (ATRA) and it is considered the gold standard for treating the dis...NIDA study identifies genes that might help some people abstain from smoking
...hers a step closer toward tailoring individualized drug therapy for addiction based on an individual’s unique genetic makeup. “This research marks the first time we’ve been able to identify genes involved in the ability to quit smoking,?says NIDA Director Dr. Nora D. Volkow. “It marks a movement from ...UCLA study uncovers clues for why Graves' disease attacks the eyes
...l lifespan. The team plans to develop an antibody drug to block the receptor from interacting with the T-cells and slow down the disease. In Graves?disease, the thyroid gland goes into overdrive, producing excess levels of hormone that attack the tissue behind the eye, causing them to protrude. In ...NIAID expands capability for influenza research and surveillance
...earch activities will involve evaluating antiviral drug regimens and factors that drive drug resistance; identifying viral markers that may indicate how a virus becomes deadly, adapts and trans...Researchers wake up viruses inside tumors to image and then destroy cancers
...n the market ?one of which is the multiple myeloma drug Velcade ?to light up tumor viruses on a gamma came...til they hit upon Velcade, a targeted chemotherapy drug already approved for use in multiple myeloma. "We were both surprised and lucky," he says. "Velcade ...Scientists identify pancreatic cancer stem cells
...hard to treat, a new approach might be to design a drug that specifically targets pancreatic cancer stem c...g with normal stem cell function." While such a drug has not been developed, ongoing research suggests it is possible to do so, she added. The study a...Study suggests some drug resistance to influenza B medications
... The researchers identified a variant with reduced drug sensitivity in one (1.4 percent) of the 74 childre...ralia, comment on the findings concerning possible drug resistance to influenza B medications. “The report by Hatakeyama et al raises more questions tha...Gut research yields new anti-cancer approach
...toxicity. That provides at least the hope that the drug class may not be prohibitively toxic in humans, th...tors reduce tubulin levels, older anti-microtubule drug classes; Vinca alkaloids, taxanes (including Taxol) and epithiolones; interfere with microtubule dyn...... highly addictive, researchers have also shown the drug to enhance learning and memory—a property that has launched efforts to develop nicotine-like drugs to treat cognitive deficits in Alzheimer’s and Parkinson’s diseases, schizophrenia, and attention-deficit/hyperactivity disorder. A key problem in des...