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Tag: "drug" at biology news

Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily

...mputer simulations of HIV dynamics to help further drug discovery and prevent deadly infections. “We found that HIV fusion peptide dramatically decreases the amount of energy needed to bend a cell-like membrane,” said Stephanie Tristram-Nagle, associate research professor of biological physics at Carnegi...

FDA sees nanotech challenges in every product category it regulates

...gy impacts every area of FDA responsibility—drugs, drug delivery systems, cosmetics, medical devices, and food products. Overall, the agency regulates products that are worth nearly $1.5 trillion annually and that account for almost 25 percent of US consumer spending. “Today, there are more than 500 man...

Agent slows aging in mice

...rch is needed before any possible human anti-aging drug could emerge, Miller says. “Even if this agent turns out to be good for mice, it won’t be possible to tell without careful studies of humans whether NDGA is beneficial, useless, or harmful to people. Occasionally, something that is harmless in m...

Cells re-energize to come back from the brink of death

...erous. The St. Jude study also suggests that a drug that disrupts a cancer cell’s ability to block thi...ram to kill the cell. Such a specifically targeted drug might be more effective and less toxic than standard chemotherapy. A report on this work is in the J...

Blood test may help signal tumor's remission, return in throat cancer patients

...sue a second line of treatment, such as surgery or drug therapy. “Cancers of the head and neck are insidi...t that this protein may represent a new target for drug therapy. Drugs that help turn off NF-kappaB are currently being tested in clinical trials at NIH and...

Old memory traces in brain may trigger chronic pain

...rn’s Feinberg School of Medicine, has identified a drug that controls persistent nerve pain by targeting t...t experiences the emotional suffering of pain. The drug is D-Cycloserine, which has been used to treat phobic behavior over the past decade. In animal ...

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

...thal form of human malaria has become resistant to drug treatment in the past three decades. They have bee...ibed and expressed two other genes known to confer drug resistance. "Now that we have these genes expressed in a convenient yeast system, we can work to ...

Millions of children denied drug that costs less than $3 a year

...developing countries are being denied an effective drug that costs less than $3 a year, according to an ed...o a normal life by taking a single daily dose of a drug (phenobarbital) that costs less than $3 (£1.5; €2.2) each year. The World Health Organisation rec...

In mice, drug protects against diabetes and atherosclerosis

Blocking a single protein with an experimental drug prevented and treated both type 2 diabetes and ath... Professor of Genetics and Complex Diseases. "This drug is very effective in treating diabetes and heart disease in mice at the same time, and we believe it...

Newly found sensing system enables certain bacteria to resist human immune defenses

...health, especially due to increasing problems with drug resistance, and these findings may help chart a pa...has been called a premier target for antimicrobial drug discovery, but little corresponding work has been done with gram-positive bacteria,” Dr. Otto says. ...

Breakthrough developments in rheumatoid arthritis reported

...ed studies on biomarkers and genetic influences on drug response at the same meeting. Identifying Immune System Mediators About one percent of the US population will develop rheumatoid arthritis, an autoimmune disease that leads to painful joint swelling. Scientists are cracking the genetic co...

U-M researchers discover gene switched off in cancer can be turned on

...n a single tumor are not the same. Giving a single drug or drug combination to 500 people is setting ourselves up for failure, much like a one-size-fits-all clothin...

Migration alert -- How tumor cells home in on the lymphatic system

...he explains. “Therapeutically, it indicates that a drug target for lymph node metastases could be blocking the signaling molecule or its receptor on the tumor cell.”...

Researchers shed light on mechanism of action used by anti-cancer drug

...vered a new mechanism of action of the anti-cancer drug sorafenib, which could stimulate the development of novel regimens in which it is combined with other molecularly targeted agents for patients with blood cancers and solid tumors. In the new study, led by Steven Grant, M.D., Massey’s associate dire...

Researchers reveal structure of protein altered in autism

...urotransmission during development, new leads into drug therapies may emerge. “We really don’t know what causes autism, but this research represents a solid starting point,” said Sarah Dunsmore, Ph.D., program director with the National Institute of General Medical Sciences, part of the National Inst...

Could fungal collection hold the key to new life-saving drugs?

... scientists from different disciplines to focus on drug discovery. They have developed test systems to detect biological activity in samples of natural products that could lead to new medicinal products. Previous work at SIDR found activities from plant extracts against diabetes, obesity and psoriasis. ...

Penn researchers link cell's protein recycling systems

...ivated the autophagy system by feeding the flies a drug called rapamycin, neurodegeneration was prevented.” The accumulated misfolded proteins were cleared out by the lysosome system. “Then we knew that this system can compensate for the impaired proteasome function, which in itself tells us that the two ...

Bacteria ferry nanoparticles into cells for early diagnosis, treatment

...icles, each of which can in turn carry hundreds of drug molecules, depending on the size of the nanopartic...to monitor the progress of disease and response to drug therapy. The carbon nanotubes could be delivered into diseased cells and then exposed to light, caus...

454 sequencing identifies HIV drug resistance at early stage

...r™ system to identify previously undetectable rare drug resistant HIV variants in samples from an earlier ...pective analysis of 258 blood samples taken before drug treatment from HIV infected individuals. The results were presented today at the XVI International H...

Cancer stem cells similar to normal stem cells can thwart anti-cancer agents

...rmal stem cells were protected equally by multiple drug resistance transporters, even if the bulk of the tumor responded to chemotherapy. According to Dr. Donnenberg, the very fact that cancers can and do relapse after apparently successful therapy indicates the survival of a drug-resistant, tumor-init...

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