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Tag: "driving" at biology news

New strategy rapidly identifies cancer targets

..."This approach gives us a way to figure out what's driving the growth of a cancer in an individual patient an... a tyrosine kinase gets stuck in an "on" position, driving out-of-control cell division and, ultimately, cancer. This potentially devastating kinase activation...

A new tool against brain disease

...ear from this analysis that the virus was actually driving these high levels of PD-1 expression, and that you could actually change the PD-1 level by getting rid of the viral antigen with drugs," said Walker. An antigen is a protein on a virus or other infectious agent that triggers an immune reaction. ...

How HIV 'exhausts' killer T cells

...ear from this analysis that the virus was actually driving these high levels of PD-1 expression, and that you could actually change the PD-1 level by getting rid of the viral antigen with drugs," said Walker. An antigen is a protein on a virus or other infectious agent that triggers an immune reaction. ...

Scientists aim to thwart use of flu as bioweapon

... was seen as humdrum and routine, and there was no driving force to do that research. It just sort of blended into the background. People assumed that since there is a vaccine, it wasn't a disease of interest any more. "But with bird flu on the horizon and the vaccine shortages that have occurred in recent ...

Mass. General study finds potential ovarian cancer stem cells

...of tumor cells that appear to act like stem cells, driving the tumor's ability to grow and spread. If some of these specialized cells escaped destruction by chemotherapy or radiation, the tumor would be able to recur quickly, often in a form resistant to chemotherapy. Similar cancer stem cells have been pr...

Study reveals mass migration of mormon crickets driven by hunger, fear

... ground, destroying farmland and causing hazardous driving conditions along the way. The research team, led...rvations and experimentation to determine that two driving forces are behind the migration: a need for protein and a fear of cannibalism. Their results reve...

History of human cannibalism eats away at researchers

...ed with cannibalism has not been a major selective driving force on the prion protein gene, as has recently been proposed. Their work also has important scientific implications for researchers using a specific class of DNA markers called SNPs (single nucleotide polymorphisms) to examine genetic associations...

Scientists discover new genetic subtypes of common blood cancer

...ments DePinho. "If you know that a certain gene is driving the disease and influences the clinical behavior of the disease in humans, it immediately goes to the top of the list as a prime candidate for drug development." ...

Genome changes tracked during multiple myeloma initiation, progression and treatment

...underlies MM, the full landscape of genomic events driving cancer initiation, progression, and response to treatment have remained hidden from view. Drs. Ron A. DePinho from the Dana-Farber Cancer Institute, Cameron Brennan of Memorial Sloan-Kettering Cancer Center, and John Shaughnessy of the Myeloma Instit...

One in 14 men having a heart attack drive themselves to hospital

...essential that people are warned of the dangers of driving when they are obviously unwell and encouraged to call an ambulance immediately if they suspect they are having a heart attack" concludes Dr O'Donnell. "And it's also time to challenge the image of the typical male heart attack victim. "We are...

Biologists develop genome-wide map of miRNA-mRNA interactions

...od that asked whether the 3' UTR part of mRNAs was driving regulation during development in a living organism. Their research appears in the most recent issue of Current Biology. In mapping miRNA targets, the research team examined the function of the genome of C. elegans, the first animal species who...

Mayo Clinic researchers challenge sepsis theory

...s caused us to ask, 'Could there be something else driving sepsis, other than the classic poisoning explanation?'" Mayo Discovers Key Piece of the Puzzle Dr. Platt and colleagues discovered several years ago that certain naturally-occurring molecules can stimulate receptors once thought to be exclusive f...

Evolution follows few of the possible paths to antibiotic resistance

...here are many alternate routes one might follow in driving from Boston to New York, one intrinsic property of DNA is that very many distinct mutational paths link any two variants of a gene," says lead author Daniel M. Weinreich, a research associate in Harvard's Department of Organismic and Evolutionary Bio...

Climate change drives widespread amphibian extinctions

...ase that is wiping out entire frog populations and driving many species to extinction. Published in the Jan. 12 issue of the journal Nature, the study reveals how the warming may alter the dynamics of a skin fungus that is fatal to amphibians. The climate-driven fungal disease, the author's say, has hundred...

How 'hot' emotional brain interferes with 'cool' processing

...everyday life," Dolcos added. "For example someone driving on a highway, attempting to pay attention to the driving task might encounter an emotional distracter such as an accident. As everybody knows, at that moment...

Mayo Clinic collaboration discovers protein amplifies DNA injury signals

...akes the gene unstable. Genomic instability is the driving force in tumor formation, which is why cancer researchers around the world are focusing on understanding the DNA damage response pathway. Knowing how the cell communicates DNA injury to alert the repair system is an important first step to designing ...

Warming trend may contribute to malaria's rise

...an that temperature is the only or the main factor driving the increase in malaria, but that it is one of many factors that should be considered," Pascual said. The new study is slated to be published online this week in the Proceedings of the National Academy of Sciences. After being nearly or completely e...

HIV/AIDS rates in Tijuana, Mexico increasing at alarming rate

...gests that injection drug use and sex trade may be driving the HIV epidemic in Tijuana. The population's mobility is also a consideration; 64% of Tijuana residents report crossing the border into the United States at least once a month. "HIV prevention should be considered a public health priority," said B...

HIV accessory protein disables host immunity via receptor-protein intermediary

...Vpr hitches a ride on the glucocorticoid receptor, driving glucocorticoid to bind to PARP-1?which, in turn, inactivates it. "Ultimately, glucocorticoid is really an intermediary between Vpr and PARP-1," explains Weiner. Weiner cites several potential clinical implications of this basic research. These findi...

Polio vaccination strategies assessed as eradication nears

...vaccine (OPV), one of the vaccines instrumental in driving the disease to near-eradication, contains weakened live virus strains. The vaccine is highly effective, easy to administer, relatively inexpensive, and has been used for more than 40 years. Those given the vaccine excrete, or "shed," virus in their s...

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