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Tag: "downstream" at biology news

Tamoxifen-like drug suggests new ways to selectively block estrogen

...he way it interacts with a whole series of related downstream molecules. And those interactions explain why these drugs have different effects in different locations, such as breast, bone or uterus." This finding opens a new arena for drug design, suggests Greene. Nuclear receptors, such as the estrogen recept...

Used in a new way, RNA interference permanently silences key breast cancer gene

...e valuable insights into the role of STAT3 and its downstream targets," adds Arlinghaus, who also will discuss the work in a mini symposium at the AACR meeting. RNAi has been employed as a laboratory tool to knock down expression of genes in a variety of cells and organisms. It works by introducing a small dou...

Brain-mapping technique aids understanding of sleep, wakefulness

...s project to these cells, sending positive signals downstream to help keep them active. The new study, however, shows that these acetylcholine-producing neurons, or cholinergic cells, are upstream of the orexin neurons as well ?the two send positive, reinforcing signals back and forth. "By being active, animal...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

...therapy—for example, a poor response may stem from downstream signaling events rather than from problems with drug metabolism. But the authors caution that the mechanisms connecting these genetic signatures to specific outcomes—and the mechanisms that produce a positive interferon response—have yet to be establ...

Affymetrix and Stratagene Announce Strategic Software Alliance

...ne's ArrayAssist software, which provides advanced downstream analysis capabilities such as gene clustering, pattern detection, and interactive visualizations. "ArrayAssist Lite software will provide highly accurate, precise and sensitive methods needed to support expression research," said Jason Goncalves, Ge...

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