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Tag: "doses" at biology news

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

...y could CPD photolyase transgenicanimals withstand doses of UV light that cause severe sunburn in normalmice, but they also showed superior resistance to UV-induced skincancer. This work clearly points to CPD lesions as the majorintermediate in UV-induced cellular damage leading to non-melanoma skincancer....

Bacteria collection sheds light on urinary tract infections

...se of the practice of administering subtherapeutic doses of antibiotics as growth promoters in animals. E.coli is common bacteria found in humans and animals. Thousands of E.coli live in the organs of humans and animals and provide multiple benefits such as aiding in digestion of certain nutrients. Howeve...

Live Recombinant Adenovirus Vaccine Technique Explored

...quire trained personnel to administer and multiple doses to provide immunity, which is not feasible for people living in many parts of the world,?explained Gary Ketner, PhD, senior author of the study and professor with the W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Bloom...

Female sex hormones play a vital role in defense against sexually transmitted diseases

...rogesterone, were protected, but only if the virus doses were weakened. In the second study, just like in the first study, mice were treated with hormones but, before being exposed to the real herpes virus, they received a vaccine Surprisingly, unlike in the first study, the progesterone-treated mice and...

Gene variations explain drug dose required to control seizures

...t and lengthy process because of the wide range of doses required by different patients and the drug's narr...or a particular treatment. Similarly, appropriate doses of carbamazepine take time to determine because of the drug's variable affects on patient metabolism...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

... the other two groups received oneof two different doses of the VRP-neu vaccine. Researchers thenimplanted a HER2/neu-positive tumor into mammary tissue in the mice.All of the control mice developed breast cancer but only one mouse ineach of the VRP-neu groups did. In short, 86 percent of mice thatreceived...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

... the other two groups received oneof two different doses of the VRP-neu vaccine. Researchers thenimplanted a HER2/neu-positive tumor into mammary tissue in the mice.All of the control mice developed breast cancer but only one mouse ineach of the VRP-neu groups did. In short, 86 percent of mice thatreceived...

Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra

...y support dense grasslands if they receive regular doses of fertilizer in the form of bird droppings. On islands without foxes, seabirds transfer nutrients from the ocean to the land by feeding on marine fish and invertebrates and spreading nutrient-rich guano around the islands. Add foxes, and the indirec...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...e, so that's good. We now know we can use very low doses that are still effective, so that's good. But we need a safety net. Once we turn it on, it's on for life. So we have to control it, and we're working on this as we speak. But it's not ready for clinical trials.?/p> About a half million Americans ...

Researchers add new tool to tumor-treatment arsenal

...an continue to multiply. The dilemma is that high doses of DNA-damaging agents can be toxic, and doses that are too low allow for DNA repair and further cell growth. Thus, says Dr. Thomas, there is need ...

Study Models Impact Of Anthrax Vaccine

....The current licensed anthrax vaccine requires six doses over an18-month period to provide immunity. The researchers looked at whatimpact a new and improved anthrax vaccine could have, and evaluated arange of vaccine characteristics, which could begin to provide immunityranging between 7 and 28 days. When ...

Gene therapy for Parkinson's disease moves forward in animals

...e, so that's good. We now know we can use very low doses that are still effective, so that's good. But we need a safety net. Once we turn it on, it's on for life. So we have to control it, and we're working on this as we speak. But it's not ready for clinical trials." About a half million Americans strugg...

Norovirus, AIDS vaccine and Hepatitis Virus

... could be used alone, without the need for booster doses with viral proteins, for large-scale immunization programs," say the researchers. (D.K. Singh, Z. Liu, D. Sheffer, G.A. Mackay, M. Smith, S. Dhillon, R. Hegde, F. Jia, I. Adany, O. Narayan. 2005. A noninfectious simian/human immunodeficiency virus D...

New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

...ns.?/p> The PK/PD approach aims to ensure that doses tested in clinical trials are adequate and likely to yield good results, said Dr. William Craig, a professor of medicine at the University of Wisconsin, adding that until now, “many, many antibiotics that initially came out have either had their dosa...

Nanoparticles offer new hope for detection and treatment

...t a therapeutic level." Using nanoparticles, drug doses could be much smaller than doses typically used in chemotherapy, making the procedure potentially much safer. "The other side of tha...

Buying Time Through Hibernation on Demand

... by allowing patients to tolerate higher radiation doses without damaging healthy tissue. Cancer cells, Roth explained, aren't dependent on oxygen to grow. As a result, they are more resistant to radiation than surrounding healthy cells, which need oxygen to live. Roth hypothesizes that temporarily elimina...

U-M team recovers ancient whale in Egyptian desert

... by allowing patients to tolerate higher radiation doses without damaging healthy tissue. Cancer cells, Roth explained, aren't dependent on oxygen to grow. As a result, they are more resistant to radiation than surrounding healthy cells, which need oxygen to live. Roth hypothesizes that temporarily elimina...

Nanoparticle Breast Cancer Drug Approved by FDA

... toxic solvents, Abraxane could be given at higher doses than Taxol, which may account, in part, for the increased anti-tumor activity. In addition, albumin is a protein that normally transports nutrients to cells and has been shown to accumulate in rapidly growing tumors. Therefore, Abraxane's increased ...

New understanding of DNA repair may pave way to cancer treatments

...ules like ATF2 can balance their dual roles. "High doses of radiation, as well as changes that take place in cancer and pathologic situations, can activate both functions of ATF2, which is expected to disturb the otherwise conserved balance between its role in gene regulation and the DNA damage response. W...

FDA Works To Speed The Advent Of New, More Effective Personalized Medicines

...ans to use genetic information to select the right doses of certain medications for cardiac, psychiatric diseases and cancer. "We hope ultimately to bring pharmacogenomics, a way in which to foster the personalizing of medicine, to every healthcare professional's prescription pad for the benefit of their ...

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