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Tag: "dose" at biology news

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

...ies that protected them from many times the lethal dose of the bacteria. "Our data, the authors conclude, "provide the first evidence of plague vaccines that do not suppress innate immune responses ?and that may be useful for plague vaccination in animals, and, perhaps, humans." The next steps include te...

Cancer drug slows poxvirus in mice

...ly new cancer drug can survive an otherwise lethal dose of vaccinia virus, a relative of smallpox virus, r...e with either saline solution or with Gleevec at a dose equivalent to that given to humans being treated for CML. Next, they exposed the mice to ordinarily ...

Does vitamin C help prevent or treat the common cold? Maybe not, after all.

...st 65 years. All of these studies compared a daily dose of 200mg of vitamin C or more against a dummy pill...the seven trials, patients took a single very high dose of the vitamin (8 g) on the day their symptoms started and experienced a shorter illness compared wi...

Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants

...he study, and all of the infants received a single dose of nevirapine and continuous zidovudine therapy after birth. At either two or five months after delivery, all three drugs taken by the mothers were found in breast milk in concentrations similar to or higher than those found in the mothers' blood. I...

NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma

...tumor-fighting capacity. They also received a high dose of Interleukin-2 (IL-2), a protein made by the bod...d to the chemotherapy and administration of a high dose of IL-2 were easily managed. The results of this study prove that a combination of chemotherapy and...

New vaccine means bye-bye to bacteria in the lung

...n and protected the mice from exposure to a deadly dose of the bacteria. Importantly, the mice could be repeatedly given the vaccine and the immune response against P. aeruginosa was boosted. Usually, adenovirus vectors do not allow for repeated infection. These results may be useful in the development o...

'EuroVacc 02' HIV Vaccine Trial Begins

...ifferent "antigen transporters" (vectors). A first dose of antigen A in vector X is administered, followed by a booster using the same antigen A in vector Y this time. In this way, immune reactions to, and the consequent inhibition of the transporter are reduced. The first injections prime the immune syst...

Alcohol consumption disrupts breastfeeding hormones

...day and plain orange juice on a different day. The dose of alcohol was equivalent to that found in one to two glasses of wine. After consuming the beverages, the women used electric breast pumps to stimulate lactation. Blood samples taken throughout the procedure were analyzed for oxytocin and prolactin, ...

Mother birds increase progesterone to hatch females

...ring the first meiosis. They injected either a low dose or a high dose of progesterone (dissolved in sesame oil) or a control dose of pure sesame oil. The low dose of pro...

Wake Forest scientists find new combination vaccine effective against plague

... combination vaccine were challenged with a lethal dose of Yersinia pestis, the bacterium that causes plague, "the immune mice survived but the control mice succumbed in three days." Mizel and his graduate student, Anna Honko, found that injecting a protein taken from plague bacteria into a mouse ?one me...

Gene therapy cures inherited liver disease in rats

A single dose of gene-virus combination cured rats of a inherited liver disease in which lack of a gene causes the accumulation of bilirubin –which, untreated, results in jaundice and brain damage, said researchers at Baylor College of Medicine in a report in the ...

Secret of smallpox's success may lead to bioterror cure

...cinia virus and then is vaccinated with a very low dose of the mutant virus ?only 100 virus particles ?the mouse gets sick but eventually recovers. The more mutant virus the mice are given, the less sick they become. "If you give them a million particles, they don't even get sick -- the animals stay heal...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

...pecificity and potency so as to lower the required dose for efficacy." The study was a collaborative effort between the laboratory of Timothy J. Triche, at Children's Hospital of Los Angeles; and the laboratory of Mark E. Davis, at the Caltech. Also participating in the study were Jeremy D. Heidel and De...

Turning viruses into allies against cancer

... in biopsies taken about two weeks after the final dose in a number of patients," said Jennifer Hu, M.B.B.S., a clinical research fellow at Hammersmith Hospital (Imperial College) in London, who conducted much of the study. "In some cases necrosis was considerable." Like other oncolytic viruses, the modi...

FDA Works To Speed The Advent Of New, More Effective Personalized Medicines

... and prescribe the best available drug therapy and dose from the start. Both the guidance and a new Web page are part of a broad effort underway at FDA to foster pharmacogenomics during drug development. FDA also recently approved the first laboratory test, the Amplichip Cytochrome P450 Genotyping Test, ...

Nanoparticle Breast Cancer Drug Approved by FDA

... be delivered into the body at a 50 percent higher dose over 30 minutes. This contrasts with Taxol, in which paclitaxel is dissolved in a toxic solvent, which requires pre-medication with steroids and antihistamines to avoid hypersensitivity reactions and must be given in infusions for up to three hours....

Canada approves marijuana-based pain spray

...2.7 mg : 2.5 mg per spray, ensuring a standardized dose is delivered each time it is used. “The approval of Sativex is good news for the Canadian MS community. People living with MS and neuropathic pain need new options to address their pain. Sativex will likely be welcomed by the many people with MS, wh...

Anti cancer virotherapy well tolerated in first human administration, research finds

...ence that this research team had injected a single dose of Coxsackie A21 (CVA21) virus directly into the a...findings suggested that administration of a single dose of CVA21 directly into a cancerous tumour was well tolerated. "Administration of CVA21 may be of po...

Nanoparticles offer new hope for detection and treatment

...ility to focus more drug at the tumor site, so the dose at the site might be ten to a thousand times higher than if you had administered the drug systemically," Lanza says. The nanoparticles also may permit more effective follow up, because a doctor could use them to discern whether a tumor was still gro...

Gene Therapy Cures Inherited Liver Disease In Rats

A single dose of gene-virus combination cured rats of a inherited liver disease in which lack of a gene causes the accumulation of bilirubin –which, untreated, results in jaundice and brain damage, said researchers at Baylor College of Medicine in a report in the ...

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